Release of Drugs from Topical Preparations and their Subsequent Fate

  • J. Hadgraft


The relevance of thermodynamic activity in the formulation of topical preparations is discussed. In some situations the microviscosity of the base is also important and the technique of photon-correlation spectroscopy has been used to assess this in some gel systems. The in vitro results are compared with some in vivo data obtained from a rabbit model. The fate of a topically applied drug may be predicted using a simple pharmacokinetic model which is described.


Apparent Diffusion Coefficient Stratum Corneum Methyl Salicylate Thermodynamic Activity Percutaneous Absorption 
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© MTP Press Limited 1985

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  • J. Hadgraft

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