Release of Drugs from Topical Preparations and their Subsequent Fate
The relevance of thermodynamic activity in the formulation of topical preparations is discussed. In some situations the microviscosity of the base is also important and the technique of photon-correlation spectroscopy has been used to assess this in some gel systems. The in vitro results are compared with some in vivo data obtained from a rabbit model. The fate of a topically applied drug may be predicted using a simple pharmacokinetic model which is described.
KeywordsApparent Diffusion Coefficient Stratum Corneum Methyl Salicylate Thermodynamic Activity Percutaneous Absorption
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