Skip to main content

Drug treatment of angina pectoris

  • Chapter
Drugs in the Management of Heart Disease

Part of the book series: Current Status of Clinical Cardiology ((CSOCC,volume 2))

  • 44 Accesses

Abstract

Although this chapter is concerned mainly with the use of drugs in the symptomatic treatment of angina pectoris, it is important to examine other forms of therapy at the onset, in particular coronary artery surgery, in order to select the appropriate therapy for the individual patient.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Frankl, W.S. and Brest, A.N. (1983). What is optimal drug therapy in angina pectoris?Cardiovasc. Clin,13, 209–20

    PubMed  CAS  Google Scholar 

  2. Gordon, T., Kannel, W.B., McGee, D. and Dawber, T.R. (1974). Death and coronary attacks in men after giving up cigarette smoking: a report from the Framingham Study.Lancet,2, 1345–8

    PubMed  CAS  Google Scholar 

  3. Vokonas, P.S., Cohn, P.F., Klein, M.D., Laver, M.B. and Gorlin, R. (1974). Hemoglobin affinity for oxygen in the anginal syndrome with normal coronary arteriograms.J. Clin. Invest,54, 409–15

    PubMed  CAS  Google Scholar 

  4. Miettinen, M., Turpeinen, O., Karvonen, M.J., Elosuo, R. and Paavilainen, E. (1972). Effect of cholesterol-lowering diet on mortality from coronary heart- disease and other causes. A twelve-year clinical trial in men and women.Lancet,2, 835–8

    PubMed  CAS  Google Scholar 

  5. Committee of Principal Investigators (1978). A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate.Br. Med. J,40, 1069–1118

    Google Scholar 

  6. Clausen, J.P. and Trap-Jensen, J. (1976). Heart rate and arterial blood pressure during exercise in patients with angina pectoris. Effects of training and of nitroglycerin.Circulation,53, 436–42

    PubMed  CAS  Google Scholar 

  7. Williams, D.O. (1981). Effects of antianginal agents on the coronary circulation.Am. Heart J,101, 473–9

    PubMed  CAS  Google Scholar 

  8. Hoffman, J.I.E. and Buckberg, G.D. (1979). Transmural variations in myocardial perfusion. In Yu, P.N. and Goodwin, J.F. (eds)Progress in Cardiology. ( Philadelphia: Lea & Febiger )

    Google Scholar 

  9. Rubio, R. and Berne, R.M. (1975). Regulation of coronary blood flow.Prog. Cardiovasc. Dis,18, 105–22

    PubMed  CAS  Google Scholar 

  10. Prinzmetal, M., Kennamer, R., Merliss, R., Wada, T. and Bor, N. (1959). Angina pectoris. I. A variant form of angina pectoris: preliminary report.Am. J. Med,27, 375–88

    PubMed  CAS  Google Scholar 

  11. Sonnenblick, E.H., Ross, J. Jr and Braunwald, E. (1968). Oxygen consumption of the heart: newer concepts of its multifactorial determination.Am. J. Cardiol,22, 328–36

    PubMed  CAS  Google Scholar 

  12. Sonnenblick, E.H. and Skelton, C.L. (1971). Myocardial energetics: basic principles and clinical implications.N. Engl. J. Med,285, 668–75

    PubMed  CAS  Google Scholar 

  13. Frishman, W.H., Weksler, B., Christodoulon, P., Smithen, C. and Killup, T. (1974). Reversal of abnormal platelet aggregability and change in exercise tolerance in patients with angina pectoris following oral propranolol.Circulation,50, 887–96

    PubMed  CAS  Google Scholar 

  14. Nayler, W.A. (1981). Protection of the ischaemic heart.Res. Clin. Forums,3, 59–71

    Google Scholar 

  15. MacClean, D. and Feely, J. (1983). Calcium antagonists, nitrates, and new antianginal drugs.Br. Med. J,286, 1127–30

    Google Scholar 

  16. The Norwegian Multicentre Study Group (1981). Timolol induced reduction in mortality and reinfarction in patients surviving myocardial infarction.N. Engl. J. Med,304, 801–7

    Google Scholar 

  17. Beta Blocker Heart Attack Study Group (1981). The beta-blocker heart attack trial.J. Am. Med. Assoc,246, 2073–4

    Google Scholar 

  18. Hansteen, V., Moinichen, E., Lorentsen, E., Anderson, A., Strom, O., Soiland, K., Dyrbekk, D., Refsum, A.-M., Tromsdal, A., Knudsen, K., Eika, C. and Bakken, J. Jr (1982). One year’ s treatment with propranolol after myocardial infarction: preliminary report of Norwegian Multicentre Trial.Br. Med. J,184, 155–60

    Google Scholar 

  19. Fox, K.M., Chopra, M.P., Portal, R.W. and Aber, C.P. (1975). Long term beta blockade: possible protection from myocardial infarction.Br. Med. J,1, 117–19

    PubMed  CAS  Google Scholar 

  20. Brunton, T.L. (1867). On the use of nitrate of amyl in angina pectoris.Lancet,2, 97–9

    Google Scholar 

  21. Murrell, W. (1879). Nitroglycerin as a remedy for angina pectoris.Lancet,1, 113–15

    Google Scholar 

  22. 22.Axelsson, K.L., Wikberg, J.E.S. and Andersson, R.G.G. (1979). Relationship between nitroglycerin, cyclic GMP and relaxation of vascular smooth muscle.Life Sci,24, 1779–86

    Google Scholar 

  23. Morcillio, F., Reid, P.R., Dubin, N., Chodgoonkar, R. and Pitt, B. (1980). Myocardial prostaglandin E release by nitroglycerin and modification by indomethacin.Am. J. Cardiol,45, 53–7

    CAS  Google Scholar 

  24. Anderson, G.H. Jr, Hueber, P., Sterling, C., Twan, E. and Schroeder, E.T. (1980). Effect of nitroglycerin on prostacyclin production in rat aorta.Circulation,62, ( Suppl. Ill ), 326. No. 1257

    Google Scholar 

  25. Cohn, P.F. and Gorlin, R. (1974). Physiologic and clinical actions of nitroglycerin.Med. Clin. N. Am,58, 407–15

    PubMed  CAS  Google Scholar 

  26. Burggraf, G.W. and Parker, J.O. (1974). Left ventricular volume changes after amyl nitrate and nitroglycerin in man as measured by ultrasound.Circulation,49, 136–43

    PubMed  CAS  Google Scholar 

  27. Mason, D.T. and Braunwald, E. (1965). The effects of nitroglycerin and amyl nitrate on arteriolar and venous tone in the human forearm.Circulation,32, 755–66

    PubMed  CAS  Google Scholar 

  28. Battock, D.J., Alvarez, H. and Chidsey, C.A. (1969). Effects of propranolol and isosorbide dinitrate on exercise performance and adrenergic activity in patients with angina pectoris.Circulation,39, 157–69

    PubMed  CAS  Google Scholar 

  29. Epstein, S.E. and Braunwald, E. (1968). Inhibition of the adrenergic nervous system in the treatment of angina pectoris.Med. Clin. N. Am,52, 1031–9

    PubMed  CAS  Google Scholar 

  30. Cohen, M.V., Downey, J.M., Sonnenblick, E.H. and Kirk, E.S. (1973). The effects of nitroglycerin on coronary collaterals and myocardial contractility.J. Clin. Invest,52, 2836–47

    PubMed  CAS  Google Scholar 

  31. Goldstein, R.E., Stinson, E.B., Scherer, J.L. Seningen, R.P., Grehl, T.M. and Epstein, S.E. (1974). Intraoperative coronary collateral function in patients with coronary occlusive disease. Nitroglycerin responsiveness and angiographic correlations.Circulation,49, 298–308

    PubMed  CAS  Google Scholar 

  32. Moir, T.W. (1972). Subendocardial distribution of coronary blood flow and the effect of antianginal drugs.Circ. Res,30, 621–7

    PubMed  CAS  Google Scholar 

  33. Forman, R., Kirk, E.S., Downey, J.M. and Sonnenblick, E.H. (1973). Nitroglycerin and heterogeneity of myocardial blood flow.J. Clin. Invest,52, 905–11

    PubMed  CAS  Google Scholar 

  34. Gorlin, R., Brachfeld, N., MacLeod, C. and Bopp, P. (1959). Effect of nitroglycerin on the coronary circulation in patients with coronary artery disease or increased left ventricular work.Circulation,19, 705–18

    PubMed  CAS  Google Scholar 

  35. Horwitz, L.D., Gorlin, R., Taylor, W.J. and Kemp, H.G. (1971). Effects of nitroglycerin on regional myocardial blood flow in coronary artery disease.J. Clin. Invest,50, 1578 - 84

    PubMed  CAS  Google Scholar 

  36. Distante, A., Maseri, A., Severi, S., Biagini, A. and Chierchia, S. (1979). Management of vasospastic angina at rest with continuous infusion of isosorbide dinitrate.Am. J. Cardiol,44, 533–9

    PubMed  CAS  Google Scholar 

  37. Sweatman, T., Strauss, G., Selzer, A. and Cohn, K.E. (1972). The long acting hemodynamic effects of isosorbide dinitrate.Am. J. Cardiol,29, 475–80

    PubMed  CAS  Google Scholar 

  38. Goldstein, R.E., Rosing, D.R., Redwood, D.R., Beisser, G.D. and Epstein, S.E. (1971). Clinical and circulatory effects of isosorbide dinitrate: comparison with nitroglycerin.Circulation,43, 629–40

    PubMed  CAS  Google Scholar 

  39. Needleman, P., Lang, S. and Johnson, E.M. Jr (1972). Organic nitrates: Relationship between biotransformation and rational angina pectoris therapy.J. Pharmacol Exp. Ther,181, 489–97

    PubMed  CAS  Google Scholar 

  40. Winsor, T., Kaye, H. and Mills, B. (1972). Hemodynamic response of oral long-acting nitrates: Evidence of gastrointestinal absorption.Chest,62, 407–13

    PubMed  CAS  Google Scholar 

  41. Franciosa, J. A., Mikulic, E., Cohn, J.N., Jose, E. and Fabie, A. (1974). Hemodynamic effects of orally administered isosorbide dinitrate in patients with congestive heart failure.Circulation,50, 1020–4

    PubMed  CAS  Google Scholar 

  42. Williams, D.E., Bommer, W., Merwin, R., Morrison, S., Miller, R.R. and Mason, D.T. (1976). Prolonged effectiveness of oral vasodilator therapy in chronic congestive heart failure with isosorbide dinitrate.Am. J. Cardiol,37, 182

    Google Scholar 

  43. Schanzenbacher, P. (1983). Isosorbide mononitrate or dinitrate in coronary disease?Dtsch. Med. Wochenschr,108, 807–809

    PubMed  CAS  Google Scholar 

  44. Abrams, J. (1982). New nitrate delivery systems: Buccal nitroglycerin.Am. Heart J,105, 848–54

    Google Scholar 

  45. Davis, J.A. and Wiesel, B.H. (1955). The treatment of angina pectoris with nitroglycerin ointment.Am. J. Med,21, 230–59

    Google Scholar 

  46. Reichek, N., Goldstein, R.E., Redwood, D.R. and Epstein, S.E. (1974). Sustained effects of nitroglycerin ointment in patients with angina pectoris.Circulation,50, 348–52

    PubMed  CAS  Google Scholar 

  47. Hansen, M.S., Woods, S.L. and Willis, R.E. (1979). Relative effectiveness of nitroglycerin ointment according to the site of the application.Heart,8, 716–20

    CAS  Google Scholar 

  48. Roubin, G.S., Harris, P.J., Eckhardt, J., Hensley, W. and Kelly, D.T. (1982). Intravenous nitroglycerin in refractory unstable angina pectoris.Aust. NZ Med,12, 598–602

    CAS  Google Scholar 

  49. Day, L.J., Thibank, G.E. and Sowton, B. (1977). Acute coronary insufficiency. Review of 46 patients.Br. Heart J,39, 363–70

    PubMed  CAS  Google Scholar 

  50. Mikolich, J.R., Nicoloff, N.B., Robinson, P.H. and Logue, R.B. (1980). Relief of refractory angina with continuous intravenous infusion of nitroglycerin.Chest,77, 375–9

    PubMed  CAS  Google Scholar 

  51. Armstrong, P.W., Armstrong, J.A. and Marks, G.S. (1980). Pharmacokinetic- haemodynamic studies of intravenous nitroglycerin in congestive cardiac failure.Circulation,62, 160–6

    PubMed  CAS  Google Scholar 

  52. McNiff, E.F., Yacobi, A., Young-Chang, F.M., Golden, L.H., Goldfarb, A. and Fung, H.L. (1981). Nitroglycerin pharmacokinetics after intravenous infusion in normal subjects.J. Pharm. Sci,70, 1054–8

    PubMed  CAS  Google Scholar 

  53. Kaplan, K., Davison, R., Parker, M., Teagarden, R. and Lesch, M. (1981). Efficacy of intravenous nitroglycerin in the treatment of angina at rest unresponsive to standard nitrate therapy.Circulation,64, (Suppl. IV), iv–11

    Google Scholar 

  54. Flaherty, J.T. (1982). Intravenous nitroglycerin.Johns Hopk. Med.J,151, 36–40

    Google Scholar 

  55. Kaplan, K., Davison, R., Parker, M., Przybylek, J., Teagarden, J.R. and Lesch, M. (1983). Intravenous nitroglycerin for the treatment of angina at rest unresponsive to standard nitrate therapy.Am. J. Cardiol,51, 694–8

    PubMed  CAS  Google Scholar 

  56. Baaske, D.M., Amanin, A.H., Wagenknecht, D.M., Mooers, M., Carter, J.E., Hoyt, H.J. and Stoll, R.G. (1980). Nitroglycerin compatibility with intravenous fluid filters, containers and administration sets.Am. J. Hosp. Pharm,37, 201–5

    PubMed  CAS  Google Scholar 

  57. Needleman, P. and Johnson, E.M. (1973). Mechanism of tolerance development to organic nitrates.J. Pharmacol. Exp. Ther,184, 709–15

    PubMed  CAS  Google Scholar 

  58. 58.Pitt, W.A., Friedman, R.G., Gross, S.A., Glassman, J., Keating, E.C. and Mazure, J.H. (1982). Effect of intravenous nitroglycerin on haemodynamics of congestive heart failure.Angiology,33, 294–301

    Google Scholar 

  59. Elkayam, U. and Aronow, S.W. (1982). Glyceryl trinitrate ointment and isosorbide dinitrate: A review of their pharmacological properties and therapeutic use.Drugs,23, 165–94

    PubMed  CAS  Google Scholar 

  60. Di Carlo, F.J. (1975). Nitroglycerin revisited: chemistry, biochemistry, interactions.Drug Metab. Rev,4 (i), 1–38

    PubMed  Google Scholar 

  61. Dauwe, F., Affaki, G., Waters, D.D., Theroux, P. and Mizgala, H.F. (1979). Intravenous nitroglycerin in refractory unstable angina.Am. J. Cardiol,43, 416

    Google Scholar 

  62. Van Dusen, J. and Fischl, S.J. (1981). Inhibition of nitroglycerin effect in humans by suppression of prostaglandins.Am. J. Cardiol,47, 390

    Google Scholar 

  63. Frick, M.H. and Luurila, O. (1976). Double blind titrated dose comparison of metoprolol and propranolol in the treatment of angina pectoris.Ann. Clin. Res,8, 385–92

    PubMed  CAS  Google Scholar 

  64. Becker, L.C., Fortuin, N.J. and Pitt, B. (1971). Effect of ischaemia and antianginal drugs on the distribution of radioactive microspheres in the canine left ventricle.Circulation,28, 263–9

    CAS  Google Scholar 

  65. Frick, M.H., Korhola, O. and Valle, M. (1978). Effect of beta-blockade by metoprolol on global and regional left ventricular myocardial perfusion in coronary heart disease.Eur. J. Cardiol,7, 317–25

    PubMed  CAS  Google Scholar 

  66. Thadani, U., Davidson, C., Singleton, W. and Taylor, S.H. (1979). Comparison of the immediate effects of five beta adrenoceptor blocking drugs with different ancillary properties in angina pectoris.N. Engl. J. Med,300, 750–5

    PubMed  CAS  Google Scholar 

  67. Conolly, M.E., Kersting, F. and Dollery, C.T. (1976). The clinical pharmacology of beta adrenoceptor blocking drugs.Prog. Cardiovasc. Dis,19, 203–4

    PubMed  CAS  Google Scholar 

  68. Kostis, J.B., Frishman, W., Hosier, M.H., Thorsen, N.L., Gonasum, L. and Weinstein, J. (1982). Treatment of angina pectoris with pindolol: the significance of intrinsic sympathomimetic activity of beta blockers.Am. Heart J,104, 496–504

    PubMed  CAS  Google Scholar 

  69. Clark, B.J. (1982). Beta-adrenoceptor blocking agents: Are pharmacologic differences relevant?Am. Heart J,104, 334 - 45

    PubMed  CAS  Google Scholar 

  70. Louis, W.J., McNeil, J.J., Jarrott, B. and Drummer, O.H. (1983). Beta adrenoceptor blocking drugs: Current status and the significance of partial agonist activity.Am. J. Cardiol,52, 104A–107A

    PubMed  CAS  Google Scholar 

  71. 71.Kostis, J.B., De Felice, E.A., Frichman, W., Hosier, M.H., Krieger, S.K., Aglitz, N. and Kuo, P.T. (1981). Clinical relevance of intrinsic sympathomimetic activity of beta blockers used in angina.Angiology,32, 780–7

    Google Scholar 

  72. Wilhelmsson, C. and Vedin, A. (1983). Beta blockers in ischaemic heart disease.Am. J. Cardiol,52, 108A–112A

    PubMed  CAS  Google Scholar 

  73. Pine, M., Favrot, L., Smith, S., McDonald, K. and Chidsey, C.A. (1975). Correlation of plasma propranolol concentration with therapeutic response in patients with angina pectoris.Circulation,52, 886–93

    PubMed  CAS  Google Scholar 

  74. George, C.F., Fenyvesi, T. and Dollery, C.T. (1973). Pharmacological effects of propranolol in relation to plasma levels. In Davies, D.S. and Prichard, B.N. (eds)Biological Effects of Drugs in Relation to their Plasma Concentration, p. 123. ( London: Macmillan )

    Google Scholar 

  75. Jackson, G., Atkinson, L. and Oram, S. (1975). Reassessment of failed beta blocker treatment in angina pectoris by peak-exercise heart rate measurements.Br. Med. J,3, 616–18

    PubMed  CAS  Google Scholar 

  76. Oates, J.A., Conolly, M.E., Prichard, B.N.C., Shand, D.G. and Schapel, G. (1977). The clinical pharmacology of antihypertensive drugs. In Gross, F. (ed.)Antihypertensive Agents. ( Berlin: Springer )

    Google Scholar 

  77. Alderman, E.L., Coltart, J., Wettach, G.E. and Harrison, D.C. (1974). Coronary artery syndromes after sudden propranolol withdrawal.Ann. Intern. Med,81, 625–7

    PubMed  CAS  Google Scholar 

  78. Miller, R.R., Olsen, H.G., Amsterdam, E.A. and Mason, D.T. (1975). Propran¬olol withdrawal rebound phenomenon.N. Engl. J. Med,293, 416–18

    PubMed  CAS  Google Scholar 

  79. Golding, L.A.R., Loop, F.D., Sheldon, W.C., Taylor, P.C., Groves, L.K. and Cosgrove, D.M. (1978). Emergency revascularisation for unstable angina.Circulation,58, 1163–6

    PubMed  CAS  Google Scholar 

  80. National Co-operative Study Group to compare surgical and medical therapy. Unstable angina pectoris (1978) II. In hospital experience and initial follow up results in patients with one, two and three vessel disease.Am. J. Cardiol,42, 839–48

    Google Scholar 

  81. Maseri, A., L’ Abbate, A., Baroldi, G., Chierchia, S., Marzilli, M., Ballestra, A.M., Severi, S., Parodi, O., Biagini, A., Distante, A. and Pesola, A. (1978). Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from the study of pre-infarction angina.N. Engl. J. Med,299, 1271–7

    PubMed  CAS  Google Scholar 

  82. Yasue, H., Touyama, M., Shimamoto, M., Kato, H., Tanaka, S. and Akiyama, F. (1974). Role of the autonomic nervous system in the pathogenesis of Prinzmetal’ s variant form of angina.Circulation,50, 534–9

    PubMed  CAS  Google Scholar 

  83. Goldberg, S., Reicheck, N., Wilson, J., Hirshfield, J.W. Jr, Muller, J. and Kastor, J. A. (1979). Nifedipine in the treatment of Prinzmetal’ s (variant) angina.Am. J. Cardiol,44, 804 - 810

    PubMed  CAS  Google Scholar 

  84. Rodger, C. and Stewart, A. (1978). Side effects of nifedipine.Br. Med. J,1, 1611–20

    Google Scholar 

  85. Jariwalla, A.G. and Anderson, E.G. (1978). Production of ischaemic cardiac pain by nifedipine.Br. Med. J,1, 1181 - 2

    PubMed  CAS  Google Scholar 

  86. Debaiseux, J.C., Theroux, P., Waters, D.D. and Mazgala, H.F. (1980). Haemodynamic effects of a single oral dose of nifedipine following acute myocardial infarction.Chest,78, 574–9

    Google Scholar 

  87. Theroux, P., Waters, D.D., Debaiseux, J.C., Szlacheie, J., Mizgala, H.F. and Bourassa, M.G. (1980). Hemodynamic effects of calcium ion antagonists after an acute myocardial infarction.Clin. Invest. Med,3, 81–5

    PubMed  CAS  Google Scholar 

  88. Morledge, J. (1973). Effects of perhexiline maleate in angina pectoris: double blind clinical evaluation with ECG treadmill exercise testing.Postgrad. Med. J,49, 64–7

    PubMed  Google Scholar 

  89. Hudak, W.J., Lewis, R.E., Lucas, R.W. and Kuhn, W.L. (1973). Review of the cardiovascular pharmacology of perhexilene.Postgrad. Med. J., Suppl 16, 16–25

    Google Scholar 

  90. Opie, L.H. (1980) Drugs and the heart. III. Calcium antagonists.Lancet,1, 806 - 9

    PubMed  CAS  Google Scholar 

  91. Neumann, M. and Luisada, A. A. (1966). Double-blind evaluation of orally ad-ministered iproveratil in patients with angina pectoris.Am. J. Med. Sci,251, 552–6

    PubMed  CAS  Google Scholar 

  92. Pine, M.B., Citron, P.D., Bailly, D.J., Butman, S., Plasencia, G.D., Landa, D.W. and Wong, R.K. (1982). Verapamil versus placebo in relieving stable angina pectoris.Circulation,65, 17–22

    PubMed  CAS  Google Scholar 

  93. Sandler, G., Clayton, G.A. and Thornicroft, S.C. (1968). Clinical evaluation of verapamil in angina pectoris.Br. Med. J,3, 224–7

    PubMed  CAS  Google Scholar 

  94. Aritman, K. and Ryden, L. (1982). Comparison of metoprolol and verapamil in the treatment of angina pectoris.Am. J. Cardiol,49, 821–7

    Google Scholar 

  95. De Ponti, C., Mauri, F., Gilberto, G.R. and Caru, B. (1979). Comparative effects of nifedipine, verapamil, isosorbide dinitrate and propranolol on exercise-induced angina pectoris.Eur. J. Cardiol,10, 47–58

    PubMed  Google Scholar 

  96. 96.Frishman, W.H., Klein, N.A., Strom, J. A., Willems, H., Lejeintel, Th., Pollack, S., Doyle, R., Kirsten, E. and Sonnenblick, E.H. (1982). Superiority of verapamil to propranolol in stable angina pectoris. A double-blind randomised crossover trial.Circulation,65, (Suppl. 1), 51–9

    Google Scholar 

  97. Subramanian, V.B., Lahiri, A., Bowles, M.J., Davies, A.B. and Raftery, E.B. (1981). Long term antianginal action of verapamil assessed by quantitated serial treadmill exercise test.Am. J. Cardiol,48, 529 - 35

    PubMed  CAS  Google Scholar 

  98. Subramanian, V.B., Bowles, M.J., Davies, A.B. and Raftery, E.B. (1981). Combined therapy with verapamil and propranolol in chronic stable angina.Am. J. Cardiol,49, 125–32

    Google Scholar 

  99. Dunschede, H.B. and Grundie, P. (1975). Ergebnisse einer Feldprufung des ko- ronartherapeutikums Adalat.Med. Welt,26, 1847–50

    PubMed  CAS  Google Scholar 

  100. Folle, L.E., Ortiz, A., Artucio, R. and Dighiero, J. (1976). Efficacy of adalat in angina pectoris patients in controlled clinical trial compared with placebo. In Iatene A.D. and Lichtlen, P. (eds.)New Therapy of Ischaemic Heart Disease, pp. 200–6. ( Amsterdam: Excerpta Medica )

    Google Scholar 

  101. Moskowitz, R.M., Piccina, P.A., Nacarelli, G.V. and Zelis, R. (1979). Nifedipine therapy for stable angina pectoris: Preliminary results of effects on angina frequency and treadmill exercise response.Am. J. Cardiol,44, 811–16

    PubMed  CAS  Google Scholar 

  102. Mueller, H.S. and Chanine, R.A. (1981). Interim report of multicenter double- blind placebo controlled studies of nifedipine in chronic stable angina.Am. J. Med,71, 645–57

    PubMed  CAS  Google Scholar 

  103. Ekelund, L.G. and Oro, L. (1979). Antianginal efficacy of nifedipine with and without a beta blocker, studied with exercise test. A double blind randomised sub-acute study.Clin. Cardiol,2, 203–11

    PubMed  CAS  Google Scholar 

  104. Dargie, H.J., Lynch, P.G., Krikler, D.M., Harris, L. and Krikler, S. (1981). Nifedipine and propranolol. A beneficial drug interaction.Am. J. Med,71, 676–82

    PubMed  CAS  Google Scholar 

  105. Pool, P.E. and Seagren, S.C. (1982). Long term efficacy of diltiazem in chronic stable angina associated with atherosclerosis. Effect on treadmill exercise.Am. J. Cardiol,49, 573–7

    PubMed  CAS  Google Scholar 

  106. Strauss, W.E., Mclntyre, K.M., Parisi, A.F. and Shapiro, W. (1982). Safety and efficacy of diltiazem hydrochloride for the treatment of stable angina pectoris. Report of a co-operative clinical trial.Am. J. Cardiol,49, 560–66

    PubMed  CAS  Google Scholar 

  107. Subramanian, V.B., Bowles, M.J., Khurmi, N.S., Davies, A.B. and Raftery, A.B. (1982). Comparison of the antianginal efficacy of four calcium ion antagonists with propranolol. (Abstr.)Am. J. Cardiol,49, 929

    Google Scholar 

  108. Parodi, O., Maseri, A. and Simonetti, I. (1979). Management of unstable angina at rest by verapamil. A double-blind cross over study in coronary care unit.Br. Heart J,41, 167–74

    PubMed  CAS  Google Scholar 

  109. Hugenholtz, P.G., Michels, H.R., Serruys, P.W. and Brower, R.W. (1981). Nifedipine in the treatment of unstable angina, coronary spasm and myocardial ischemia.Am. J. Cardiol,47, 163–73

    PubMed  CAS  Google Scholar 

  110. 110.André-Fouet, X., Viallet, M., Gayet, C., Thizy, J.F., Wilner, C. and Pont, M. (1981). Diltiazem versus propranolol. A randomised trial in unstable angina. (Abstr.)Circulation,64, ( Suppl. IV ), 293

    Google Scholar 

  111. Gerstenblith, G., Onyang, P., Achuff, S., Bulkley, B., Becker, L.C., Mellitus, E.D., Boughman, K.L., Weiss, J.L., Flaherty, J.T., Kallman, C.H., Llewellyn, M. and Weisfeldt, M.L. (1982). Nifedipine in unstable angina: A double-blind randomised trial.N. Engl. J. Med,306, 885–9

    PubMed  CAS  Google Scholar 

  112. Johnson, S.M., Mauritson, D.R., Willerson, J.T., Hillis, L.D., Erck, B.J. and Brown, S.B. (1981). Comparison of verapamil and nifedipine in the treatment of variant angina pectoris. Preliminary observations in 10 patients.Am. J. Cardiol,47, 1295–1300

    PubMed  CAS  Google Scholar 

  113. Previtali, M., Salerno, J.A., Tavazzi, L., Ray, M., Medici, A., Chimienti, M., Spechia, G. and Bobba, P. (1980). Treatment of angina at rest with nifedipine. A short-term controlled study.Am. J. Cardiol,45, 825–30

    PubMed  CAS  Google Scholar 

  114. Tiefenbrunian, R.J., Sobel, B.E., Gowka, S., McKnight, R.C. and Ludbrook, P. A. (1981). Nifedipine blockade of ergonovine induced coronary arterial spasm: angiographic documentation.Am. J. Cardiol,48, 184–7

    Google Scholar 

  115. 115.Severi, S., Davies, A., Maseri, A., Marzullo, P. and L’ Abbate, A. (1980). Long term prognosis of ‘variant’ angina with medical treatment.Am. J. Cardiol,46, 226–32

    Google Scholar 

  116. Kinura, E. and Kishida, H. (1981). Treatment of variant angina with drugs. A survey of 11 cardiology institutes in Japan.Circulation,63, 844–8

    Google Scholar 

  117. Waters, D.D., Theroux, P., Szlachcic, J. and Dauwe, F. (1981). Provocative testing with ergonovine to assess the efficacy of treatment with nifedipine, diltiazem and verapamil in variant angina.Am. J. Cardiol,48, 123–30

    PubMed  CAS  Google Scholar 

  118. Yasue, H., Nagao, M., Omote, S., Takvzawa, A., Muva, K., and Tanaka, S. (1978). Coronary arterial spasm and Prinzmetal’ s variant form of angina induced by hyperventilation and tris buffer infusion.Circulation,58, 56–62

    PubMed  CAS  Google Scholar 

  119. Pilcher, J., Chandrasekhar, K.P., Russell, R.J., Boyce, M.J., Pierce, T.H. and Ikram, H. (1973). Long term assessment of perhexiline maleate in angina pectoris.Postgrad. Med. J,49, Suppl. 3, 115–18

    Google Scholar 

  120. Weissberg, P.L. (1982). Therapeutic Progress — Review V. Treatment of angina.J. Clin. Hosp. Pharm,7, 145–53

    PubMed  CAS  Google Scholar 

  121. Eichelbaum, M., Ende, M. and Remberg, G. (1979). The metabolism of 14C- verapamil in man.Drug Metab. Disp,7, 145–8

    CAS  Google Scholar 

  122. Ludbrook, P.A., Tiefenbrum, A.J., Reed, F.R. and Burton, E.S. (1982). Acute haemodynamic responses to sublingual nifedipine: dependence on left ventricular function.Circulation,65, 489–98

    PubMed  CAS  Google Scholar 

  123. McAllister, R.G. (1982) Clinical pharmacology of slow channel blocking agents.Prog. Cardiovasc. Dis,25, 83–102

    PubMed  CAS  Google Scholar 

  124. Sing, R.J., Esler, B. and McAllister, R.G. (1980). Intravenous verapamil for termination of re-entrant supraventricular tachycardias. Intracardiac studies cor¬related with plasma verapamil concentration.Ann. Intern. Med,93, 682–9

    Google Scholar 

  125. Dominic, J., McAllister, R.G., Kuo, C.S., Reddy, C.P. and Surawicz, B. (1979). Verapamil plasma levels and ventricular rate response in patients with atrial fibrillation and flutter.Clin. Pharmacol. Ther,26, 710–14

    PubMed  CAS  Google Scholar 

  126. Hoster, F.A. (1975). Pharmacokinetics of nifedipine 14C in man. In Lochner, W., Braasch, W. and Kroneberg, G. (eds)Second International Adalat Symposium, pp. 124–7. ( New York: Springer )

    Google Scholar 

  127. Pederson, O.L., Christensen, N.J. and Ranisch, K.D. (1980). Comparison of acute effects of nifedipine in normotensive and hypertensive man.J. Cardiovasc. Pharmacol,2, 357–66

    Google Scholar 

  128. Antman, E., Muller, J., Goldberg, S., MacAlpin, R., Rubenfire, M., Tabatznik, B., Liang, C.-S., Heupler, F. and Achuff, S. (1980). Nifedipine therapy for coronary-artery spasm. Experience in 127 patients.N. Engl. J. Med,302, 1269–73

    PubMed  CAS  Google Scholar 

  129. Bertrand, M.E., Leblanche, J.M. and Tilmant, P.Y. (1981). Treatment of Prinz¬metal’ s variant angina. Role of medical treatment with nifedipine and surgical coronary revascularization combined with plexectomy.Am. J. Cardiol,47, 174–8

    PubMed  CAS  Google Scholar 

  130. Shah, R.R., Oates, N.S., Idle, S.R., Smith, R.L. and Lockhart, J.D.F. (1982). Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.Br. Med. J,284, 295–9

    CAS  Google Scholar 

  131. Krikler, D. (1974). Verapamil in cardiology.Eur. J. Cardiol,2, 3–10

    PubMed  CAS  Google Scholar 

  132. Lang, R., Klein, H.O., Weiss, E., Libhaber, C. and Kaplinsky, E. (1980). Effect of verapamil on blood level and renal clearance of digoxin.Circulation,62 ( Suppl. II ), 83

    Google Scholar 

  133. Ebner, F. and Dunschede, H.B. (1976). Haemodynamic therapeutic mechanism of action and clinical findings of Adalat use based on world wide clinical trials. In Jatine, A.D. and Lichthen, P.R. (eds).3rd International Adalat Symposium, pp. 283–300. ( Amsterdam: Excerpta Medica )

    Google Scholar 

  134. Pitt, B., Elliot, E.C. and Gregg, D.E. (1967). Adrenergic receptor activity in the coronary arteries of the unanaesthetized dog.Circ. Res,21, 75–84

    PubMed  CAS  Google Scholar 

  135. McRaven, D.R., Mark, A.L., Abboud, F.M. and Mayer, H.E. (1971). Responses of coronary vessels to adrenergic stimuli.J. Clin. Invest,50, 773–8

    PubMed  CAS  Google Scholar 

  136. Kelley, K.O. and Feigel, E.O. (1978). Segmental alpha receptor mediated vasoconstriction in the canine coronary circulation.Clin. Res,43, 908–17

    CAS  Google Scholar 

  137. Yasue, H. (1980). Pathophysiology and treatment of coronary arterial spasm.Chest,78, 216–23

    PubMed  CAS  Google Scholar 

  138. Levene, D.L. and Freeman, M.R. (1976). Alpha adrenoceptor mediated coronary arterial spasm.J. Am. Med. Assoc,236, 1018–22

    CAS  Google Scholar 

  139. Gould, L.A., Reddy, C.V.R. and Gomprecht, R.F. (1973). Oral phentolamine in angina pectoris.Jpn. Heart J,14, 393–7

    PubMed  CAS  Google Scholar 

  140. Tzivoni, D., Keren, A., Benhorin, J., Gottlieb, S., Atlas, D. and Stern, S. (1982). Prazosin therapy for refractory variant angina.Am. Heart J,105, 262–6

    Google Scholar 

  141. 141.Lubbe, W.F. and White, D.A. (1978). Labetalol in hypertensive patients with angina pectoris: beneficial effect of combined alpha and beta blockade.Clin. Sci. Mol. Med,55 (Suppl. 4), 283S–286S

    Google Scholar 

  142. Halprin, S., Frishman, W., Kirschner, M. and Strom, J. (1980). Clinical pharmacology of new beta adrenergic blocking drugs. Part II. Effect of oral labetalol in patients with both angina pectoris and hypertension: a preliminary experience.Am. Heart J,99, 388–96

    PubMed  CAS  Google Scholar 

  143. Besterman, E.M.M. and Spencer, M. (1979). Open evaluation of labetalol in the treatment of angina pectoris occurring in hypertensive patients.Br. J. Clin. Pharmacol,8, 2055 - 95

    Google Scholar 

  144. Silke, B., Nelson, G.I.C., Ahija, R.C. and Taylor, S.H. (1982). Comparative haemodynamic dose response effects of propranolol and labetalol in coronary heart disease.Br. Heart J,48, 364–71

    PubMed  CAS  Google Scholar 

  145. Frishman, W.H., Strom, J.A., Kirschner, M., Poland, M., Klein, N., Halprin, S., Le Jemtel, T.H., Kram, M. and Sonnenblick, E.H. (1981). Labetalol therapy in patients with systemic hypertension and angina pectoris. Effects of combined alpha and beta adrenoceptor blockade.Am. J. Cardiol,48, 917–28

    PubMed  CAS  Google Scholar 

  146. McNeill, J.J. and Lous, W.J. (1979). A double-blind cross over comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.Br. J. Clin. Pharmacol,8, 163S–166S

    Google Scholar 

  147. Hoffman, B.B. and Lefkowitz, R.J. (1980). Alpha-adrenergic receptor subtypes.N. Engl. J. Med,302, 1390–6

    PubMed  CAS  Google Scholar 

  148. Simoons, M.L., Tummers, J., Van Meurs-Van Woezik, H. and Van Dornburg, R. (1982). Alinidine, a new agent which lowers heart rate in patients with angina pectoris.Eur. Heart J,3, 542–5

    CAS  Google Scholar 

  149. Daly, K., Bergman, G., Rothman, M., Atkinson, L., Jackson, G. and Jewitt, D.E. (1982). Beneficial effect of adding nifedipine to beta adrenergic blocking therapy in angina pectoris.Eur. Heart J,3, 42–6

    PubMed  CAS  Google Scholar 

  150. Krikler, D.M., Harris, L. and Rowland, E. (1982). Calcium channel blockers and beta blockers: Advantages and disadvantages of combination therapy in stable angina pectoris.Am. Heart J,104, 702–8

    PubMed  CAS  Google Scholar 

  151. 151.Takaro, T., Hultgren, H.N., Detre, K.M. and Peduzzi, P. (1982). The Veterans Administration Co-operative Study of Stable Angina: current status.Circulation,65, Suppl. 2, II–60–67

    Google Scholar 

  152. European Coronary Surgery Study Group (1982). Prospective randomised study of coronary artery bypass surgery in stable angina pectoris: a progress report on survival.Circulation,65, Suppl. 2, II–67–71

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 MTP Press Limited

About this chapter

Cite this chapter

Johnston, G.D. (1985). Drug treatment of angina pectoris. In: Breckenridge, A. (eds) Drugs in the Management of Heart Disease. Current Status of Clinical Cardiology, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4876-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-4876-1_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8658-5

  • Online ISBN: 978-94-009-4876-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics