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Chemistry and Biochemistry of the Amino Acids pp 338–353Cite as

Resolution of Amino Acids

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Abstract

Most of the purposes for which amino acids are needed call for resolved samples of the chiral amino acids. These are available either (i) from a natural source (ii) through asymmetric synthesis, or (iii) through resolution of a DL-amino acid obtained by synthesis. There are major limitations of supply involved in the dependence on a natural source for uncommon amino acids, and asymmetric synthesis has yet to be developed into a reliable general process. In any case, synthesis followed by resolution is usually a more attractive proposition for the supply of novel or uncommon amino acids in required amounts since, even if the other methods are at first sight more convenient, these also require separation stages and checks of optical purity. Assignment of absolute configuration is also a necessary step in the resolution of novel DL-amino acids; spectroscopic methods used for configurational assignments are discussed in Chapter 19.

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Authors
  1. G. C. Barrett
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  1. Oxford Polytechnic, UK

    G. C. Barrett

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© 1985 Chapman and Hall

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Barrett, G.C. (1985). Resolution of Amino Acids. In: Barrett, G.C. (eds) Chemistry and Biochemistry of the Amino Acids. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4832-7_10

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  • DOI: https://doi.org/10.1007/978-94-009-4832-7_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8642-4

  • Online ISBN: 978-94-009-4832-7

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