Abstract
Evolutionary guidance is discussed as a strategy for simplifying the problems associated with the use of recombinant DNA techniques to study structure-function relationships in proteins. Evidence is given that suggests that natural selection “fine tunes” the behavior of proteins. Also progress on the synthesis, cloning, and expression of a gene for pancreatic ribonuclease, designed to permit rapid modification, is reported.
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Nambiar, K.P., Stackhouse, J., Presnell, S.R., Benner, S.A. (1986). Evolutionary Guidance and the Engineering of Enzymes. In: Schneider, M.P. (eds) Enzymes as Catalysts in Organic Synthesis. NATO ASI Series, vol 178. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4686-6_20
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DOI: https://doi.org/10.1007/978-94-009-4686-6_20
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