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Non-Invasive Localized Volume Spectroscopy of Animals: Prospects from the Viewpoint of the High Resolution Spectroscopist

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NMR in Living Systems

Part of the book series: Nato ASI Series ((ASIC,volume 164))

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Abstract

The successful application of high resolution NMR methodology to human metabolism studies, whether for research or clinical-diagnostic purposes, requires the development and refinement of methods for obtaining spectra from local regions within the subject. As yet no quantitatively perfect localization method has been found, although a several somewhat imperfect methods, such as surface coil and topical magnetic resonance techniques have been used, and a number of new methods based on proton imaging technologies have been suggested. This discussion critically reviews the surface coil and topical magnetic resonance methods which have been employed for high resolution spectroscopy of animal tissues. It goes on to stress that high resolution spectroscopy of small metabolites has special limitations which will be important in defining the effectiveness of those methods which have been suggested, but not yet applied in living animal experimentation.

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Author information

Authors and Affiliations

  1. Dept. of Diagnostic Radiology, Dept. of Molecular Biophysics and Biochemistry, Yale University, P. O. Box 6666, New Haven, CT, 06511, USA

    J. R. Alger

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  1. J. R. Alger
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Editor information

Editors and Affiliations

  1. Department of Chemistry, City College of the City University of New York, USA

    Theodore Axenrod

  2. Institute of Physical Chemistry, University of Pisa, Italy

    Giulio Ceccarelli

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© 1986 D. Reidel Publishing Company, Dordrecht, Holland

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Alger, J.R. (1986). Non-Invasive Localized Volume Spectroscopy of Animals: Prospects from the Viewpoint of the High Resolution Spectroscopist. In: Axenrod, T., Ceccarelli, G. (eds) NMR in Living Systems. Nato ASI Series, vol 164. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4580-7_17

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  • DOI: https://doi.org/10.1007/978-94-009-4580-7_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8535-9

  • Online ISBN: 978-94-009-4580-7

  • eBook Packages: Springer Book Archive

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