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An Overview of Biological Applications of NMR

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NMR in Living Systems

Part of the book series: Nato ASI Series ((ASIC,volume 164))

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Abstract

Since its discovery in 1946, NMR has developed to one of the most widely used tools in chemistry and is rapidly becoming an essential technique in biology and medicine. In this introductory chapter the use of NMR in biology and biochemistry is traced from early studies of small molecules of biological interest, through the study in vitro of biopolymers and cell constituents, to the current applications of in vivo spectroscopy and imaging. The development of improved instruments and introduction of new methods that are essential to current uses are emphasized.

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References

  1. F. Bloch, Phys. Rev. 70: 460 (1946); F. Bloch, W.W. Hansen and M. Packard, Phys. Rev. 70; 474 (1946).

    Article  CAS  Google Scholar 

  2. E.M. Purcell, H.C. Torrey and R.V. Pound, Phys. Rev. 69: 37 (1946).

    Google Scholar 

  3. E.D. Becker, High Resolution N.M.R., Second Edition, (Academic Press, New York, 1980).

    Google Scholar 

  4. D.G. Gadian, Nuclear Magnetic Resonance and its Applications to Living Systems. (Oxford University Press, New York, 1982 ).

    Google Scholar 

  5. R.K. Harris, Nuclear Magnetic Resonance Spectroscopy. A Physicochemical View. ( Pitman, London, 1983 ).

    Google Scholar 

  6. E.D. Becker, R.B. Bradley and C.J. Watson, J. Am. Chem. Soc. 83: 3743 (1961).

    Article  CAS  Google Scholar 

  7. S. Goodwin, J.N. Shoolery and L.F. Johnson, J. Am. Chem. Soc. 81: 3065 (1959).

    Article  CAS  Google Scholar 

  8. T.A. Crabb, in Annual Reports on NMR Spectroscopy, ( E.F. Mooney, ed.), ( Academic Press, New York, 1975 ), 6A: 249.

    Google Scholar 

  9. J.N. Shoolery and M.T. Rogers, J. Am. Chem. Soc. 80, 5121 (1958).

    Article  CAS  Google Scholar 

  10. N.S. Bhacca, A.I. Meyers and A.H. Reine, Tetrahedron Letters, 2293 (1968).

    Google Scholar 

  11. J.E. Page, in Annual Reports on NMR Spectroscopy, ( E.F. Mooney, ed.), ( Academic Press, New York, 1970 ), 3: 149.

    Google Scholar 

  12. O. Jardetzky and C.D. Jardetzky, J. Biol. Chem. 233: 383 (1958); O. Jardetzky and C.D. Jardetzky, J. Am. Chem. Soc. 82: 222 (1960).

    CAS  Google Scholar 

  13. H.T. Miles, R.B. Bradley and E.D. Becker, Science 142: 1569 (1963).

    Article  PubMed  CAS  Google Scholar 

  14. R.R. Shoup, H.T. Miles and E.D. Becker, Biochem. Biophys. Res. Commun. 23: 194 (1966).

    Article  PubMed  CAS  Google Scholar 

  15. S.I. Chan, M.P. Schweizer, P.O.P. Tfso and G.K. Helmkamp, J. Am. Chem. Soc. 86: 4182 (1964).

    Article  CAS  Google Scholar 

  16. P.O.P. Tfso, M.P. Schweizer, and D.P. Hollis, Ann. N.Y. Acad. Sci. 158: 256 (1969).

    Article  Google Scholar 

  17. R.U. Lemieux, R.K. Kullnig, H.J. Bernstein, and W.G. Schneider, J. Am. Chem. Soc. 80: 6098 (1958).

    Article  CAS  Google Scholar 

  18. P.L. Durrette, D. Horton and N.S. Bhacca, Carbohydrate Res. 10: 565 (1969).

    Article  Google Scholar 

  19. M. Takeda and O. Jardetzky, J. Chem. Phys. 26: 1346 (1957).

    CAS  Google Scholar 

  20. D.W. Urry and M. Ohnishi, in Spectroscopic Approaches to Biomolecular Conformation, (D.W. Urry, ed.), (American Medical Association, Chicago, 1970), 263.

    Google Scholar 

  21. V.F. Bystrov, in Progress in NMR Spectroscopy, (J.W. Emsley et al., ed.), (Pergamon Press, Oxford, 1978.)

    Google Scholar 

  22. J.S. Cohen, in Experimental Methods in Biophysical Chemistry, ( C. Nicolau, ed.), ( Wiley, London, 1973 ), 521.

    Google Scholar 

  23. T.M. Shaw and R.H. Elksen, J. Chem. Phys. 18: 1113 (1950).

    Article  CAS  Google Scholar 

  24. B. Jacobson, W.A. Anderson and J.T. Arnold, Nature 173: 772 (1954).

    Article  CAS  Google Scholar 

  25. J. Eisinger, R.G. Shulman and W.E. Blumberg, Nature 192: 963 (1961); J. Eisinger, R.G. Shulman, and B.M. Szymanski, J. Chem. Phys. 36: 1721 (1962).

    Article  PubMed  CAS  Google Scholar 

  26. M. Cohen and T.R. Hughes, J. Biol. Chem. 235: 3250 (1960); M. Cohen and T.R. Hughes, J. Biol. Chem. 237: 176 (1962).

    Google Scholar 

  27. P.C. Lauterbur, J. Chem. Phys. 26: 217 (1957).

    Article  CAS  Google Scholar 

  28. W.J. Horsley and H. Sternlicht, J. Am. Chem. Soc. 90: 3738 (1968); W. Horsley, H. Sternlicht, and J.S. Cohen, J. Am. Chem. Soc. 92: 680 (1970).

    Article  CAS  Google Scholar 

  29. R.R. Ernst and W.A. Anderson, Rev. Sei. Instrum. 37: 93 (1966).

    Article  CAS  Google Scholar 

  30. J.S. Waugh, L.M. Huber and U. Haeberlen, Phvs. Rev. Lett. 20: 180 (1968). (b) A. Pines, M.G. Gibby, and J.S. Waugh, J. Chem. Phys. 59: 569 (1973).

    Article  CAS  Google Scholar 

  31. A. Pines, M.G. Gibby, and J.S. Waugh, J. Chem. Phys. 59: 569 (1973).

    Google Scholar 

  32. G. Wagner and K. Wuthrich, J. Mol. Biol. 155: 347 (1982).

    Article  PubMed  CAS  Google Scholar 

  33. J. Feigon, W. Leupin, W.A. Denny, and D.R. Kearns, Biochemistry 22: 5943 (1983).

    Google Scholar 

  34. E. Odeblad, B.N. Bhar and G. Lindstrom, Arch. Biochem. Biophys. 63: 221 (1956).

    Article  PubMed  CAS  Google Scholar 

  35. E. Odeblad and A. Ingelman-Sundberg, Acta Obst, et Gynec. Scandinav. 44: 117 (1965).

    Article  CAS  Google Scholar 

  36. R. Damadian, Science 171: 1151 (1971).

    Article  PubMed  CAS  Google Scholar 

  37. R.B. Moon and J.H. Richards, J. Biol. Chem. 248: 7276 (1973).

    PubMed  CAS  Google Scholar 

  38. D.I. Hoult, S.J.W. Busby, D.G. Gadian, G.K. Radda, R.E. Richards and P.J. Seeley, Nature 252: 285 (1974).

    Article  PubMed  CAS  Google Scholar 

  39. M.J. Dawson, D.G. Gadian and D.R. Wilkie, J. Physiol. 267: 703 (1977).

    PubMed  CAS  Google Scholar 

  40. C. Arus, M, Barany, W.M. Westler and J.L. Markley, J. Magn. Reson. 57: 519 (1984).

    CAS  Google Scholar 

  41. J.J.H. Ackerman, T. H. Grove, G.G. Wond, D.G. Gadian and G.K. Radda, Nature 283: 167 (1980).

    Article  PubMed  CAS  Google Scholar 

  42. J.J.H. Ackerman, P.J. Bore, D.G. Gadian, T.H. Grove and G.K. Radda, Phil Trans. R. Soc. Lond. B. 289: 425 (1980).

    Google Scholar 

  43. P.E. Hanley and R.E. Gordon, J. Magn. Reson. 45: 520 (1981).

    Google Scholar 

  44. M.R. Bendall and R.E. Gordon, J. Magn. Reson. 53: 365 (1983).

    Google Scholar 

  45. B.D. Ross, G.K. Radda, D.G. Gadian, G. Rocker, M. Esiri and J. Falconer-Smith, New Engl. J. Med. 304: 1338 (1981).

    Article  PubMed  CAS  Google Scholar 

  46. P.C. Lauterbur, Nature 242: 190 (1973).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, 20205, USA

    Cherie L. Fisk & Edwin D. Becker

Authors
  1. Cherie L. Fisk
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  2. Edwin D. Becker
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Editor information

Editors and Affiliations

  1. Department of Chemistry, City College of the City University of New York, USA

    Theodore Axenrod

  2. Institute of Physical Chemistry, University of Pisa, Italy

    Giulio Ceccarelli

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© 1986 D. Reidel Publishing Company, Dordrecht, Holland

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Fisk, C.L., Becker, E.D. (1986). An Overview of Biological Applications of NMR. In: Axenrod, T., Ceccarelli, G. (eds) NMR in Living Systems. Nato ASI Series, vol 164. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4580-7_1

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  • DOI: https://doi.org/10.1007/978-94-009-4580-7_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8535-9

  • Online ISBN: 978-94-009-4580-7

  • eBook Packages: Springer Book Archive

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