Abstract
The essential elements involved in the pathogenesis of AA amyloidosis have, over the last 10–15 years, been shown to be events associated with acute inflammation (1). As part of the process of inflammation cytokines (the effect of interleukin-1 being the best characterized) are released from inflammatory cells and stimulate the synthesis of acute phase proteins by the liver. Among the various acute phase proteins is the putative precursor of the AA deposit, apo-SAA, an apoprotein of HDL but one seen associated with HDL primarily during inflammation.
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© 1986 Martinus Nijhoff Publishers, Dordrecht
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Kisilevsky, R., Snow, A.D., Subrahmanyan, L., Boudreau, L., Tan, R. (1986). What Factors are Necessary for the Induction of AA Amyloidosis?. In: Marrink, J., Van Rijswijk, M.H. (eds) Amyloidosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4309-4_32
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DOI: https://doi.org/10.1007/978-94-009-4309-4_32
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