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Biochemical and Genetic Characterization of a Variant Transthyretin Causing Familial Amyloidotic Polyneuropathy

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Amyloidosis

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Abstract

Familial amyloidotic polyneuropathy (FAP) has a worldwide distribution and type I FAP is the most common disorder characterized by progressive polyneuropathy. Very little has been known about the biochemical and genetic nature of this intractable disorder. In addition there has been no diagnostic method for this progressive disorder before symptoms appear around the age of 20 to 40 years. Since this disorder is transmitted by autosomal dominant inheritance and the clinical onset is postmarital, it has long been desired to develop an early diagnostic method to predict possible transmission of the disease.

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Author information

Authors and Affiliations

  1. The Third Department of Medicine, Miyazaki Medical College, Kiyotake, Miyazaki, 889-16, Japan

    Masamitsu Nakazato, Teruyuki Kurihara & Shigeru Matsukura

  2. Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki, 889-16, Japan

    Kenji Kangawa & Hisayuki Matsuo

  3. Research Laboratory for Genetic Information, Kyushu University, Fukuoka, 812, Japan

    Hiroyuki Sasaki, Hirokazu Furuya & Yoshiyuki Sakaki

Authors
  1. Masamitsu Nakazato
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  2. Teruyuki Kurihara
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  3. Shigeru Matsukura
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  4. Kenji Kangawa
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  5. Hisayuki Matsuo
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  6. Hiroyuki Sasaki
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  7. Hirokazu Furuya
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  8. Yoshiyuki Sakaki
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Div of Immunochemistry, University Hospital Groningen, 59 Oostersingel, 9713 EZ, Groningen, The Netherlands

    Jan Marrink Ph.D.

  2. Department of Internal Medicine, Div of Rheumatology, University Hospital Groningen, Oostersingel 59, 9713 EZ, Groningen, The Netherlands

    Martin H. Van Rijswijk M.D.

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© 1986 Martinus Nijhoff Publishers, Dordrecht

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Nakazato, M. et al. (1986). Biochemical and Genetic Characterization of a Variant Transthyretin Causing Familial Amyloidotic Polyneuropathy. In: Marrink, J., Van Rijswijk, M.H. (eds) Amyloidosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4309-4_23

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  • DOI: https://doi.org/10.1007/978-94-009-4309-4_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8415-4

  • Online ISBN: 978-94-009-4309-4

  • eBook Packages: Springer Book Archive

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