Skip to main content
SpringerLink
Log in

Amyloid P-Component: Clinical Implications

  • Chapter
Book cover Amyloidosis

  • 99 Accesses

Abstract

In the course of studying the isolation of amyloid fibril proteins, the structural protein P-component was identified. In 1965 an antibody was made to a solubilized fraction of amyloid fibrils that were isolated by a technique of sucrose gradient centrifugation (1). The antibody cross reacted with a circulating plasma alpha globulin and was called P (plasma) component. This plasma component was isolated from amyloid rich tissues from patients with primary (AL) and secondary (AA) types of amyloidosis and identified as a pentagonally structured protein separate from the amyloid fibrils (2,3). Subsequent studies have shown that AP can be extracted uniquely from amyloid tissue and is identical with normal α-1-glycoprotein (4,5). Thus, AP has been the term used for the P-component associated with amyloid tissues and SAP for the P-component found in serum (6). The two proteins are believed to be completely identical and the terms AP and SAP simply denote the site from which P-component has been isolated. AP has been found associated with amyloid fibrils in primary AL (immunoglobulin light chain), secondary AA, and heredofamilial AF (prealbumin) forms of systemic amyloid disease. In addition, it has been found on all deposits of the various localized forms of amyloid with the possible exception of the intracerebral amyloid plaques and neurofibrillary tangles associated with Alzheimer’s disease (7).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cathcart, E.S., Comerford, F.R. & Cohen, A.S. New Eng. J. Med. 273, 143–146, 1965.

    Article  PubMed  CAS  Google Scholar 

  2. Bladen, H.A., Nylen, M.U. & Glenner, G.G. J. Ultrastruct. Res. 14, 449–459, 1966.

    Article  PubMed  CAS  Google Scholar 

  3. Cathcart, E.S., Shirahama, T. & Cohen A.S. Biochim. Biophys. Acta 147, 392–393, 1967.

    CAS  Google Scholar 

  4. Cathcart, E.S., Wollheim, F.A. & Cohen, A.S. J. Immunol. 99, 376–385, 1967.

    PubMed  CAS  Google Scholar 

  5. Haupt, H., Heimburger, N., Kranz, T. & Baudner, S. Hoppe-Seyler’s Z. Physiol. Chem. 353, 1841–1849, 1972.

    Article  PubMed  CAS  Google Scholar 

  6. Cohen, A.S., Franklin, E.C., Glenner, G.G. et al. In Amyloidosis. Wegelius O., Pastemack, A., Eds. Academic Press, New York, p. 9. 1976.

    Google Scholar 

  7. Westermark, P., Shirahama, T., Skinner, M. et al. Lab. Invest. 46, 457–460, 1982.

    PubMed  CAS  Google Scholar 

  8. Pinteric, L. & Painter, R.H. Can. J. Biochem. 57, 727–736, 1979.

    Article  PubMed  CAS  Google Scholar 

  9. Painter, R.H., DeEscallon, I., Massey, A. et al. Ann. N.Y. Acad. Sci. 389, 199–215, 1982.

    Article  PubMed  CAS  Google Scholar 

  10. Skinner, M., Cohen, A.S., Shirahama T. & Cathcart, E.S. J. Lab. Clin. Med. 84, 604–614, 1974.

    PubMed  CAS  Google Scholar 

  11. Coe, J.E. Contemporary Topics in Molecular Immunology 9, 211–238, 1983.

    PubMed  CAS  Google Scholar 

  12. Pepys, M.B., Dash, A.C., Fletcher, T.C. et al. Nature 273, 168–170, 1978.

    Article  PubMed  CAS  Google Scholar 

  13. Skinner, M., Pepys, M.B., Cohen, A.S. et al. In Amyloid and Amyloidosis. Glenner, G.G., Costa, P.P. & Freitas, A.F., Eds. Excerpta Medica, Amsterdam, 384–391, 1980.

    Google Scholar 

  14. Anderson, J.K. & Mole, J.E. Anal. Biochem. 123, 413–421, 1982.

    Article  PubMed  CAS  Google Scholar 

  15. Prelli, F., Pras, M. & Frangione B. J. Biol. Chem. 260, 12895–12898, 1985.

    PubMed  CAS  Google Scholar 

  16. Mantzouranis, E.C., Dowton, S.B., Whitehead, A.S. et al. J. Biol. Chem. 260, 7752–7756, 1985.

    PubMed  CAS  Google Scholar 

  17. Pontet, M., D’Asnieres, M., Gache, D. et al. Biochim. Biophys. Acta 671, 201–210, 1981.

    Google Scholar 

  18. Tatsuta, E., Sipe, J.D., Shirahama, T. et al. J. Biol. Chem. 258, 5414–5418, 1983.

    PubMed  CAS  Google Scholar 

  19. Skinner, M., Sipe, J.D., Yood, R.A. et al. Ann. N.Y. Acad. Sci. 389, 190–198, 1982.

    Article  PubMed  CAS  Google Scholar 

  20. Thompson, A.R. & Enfield, D.L. Biochemistry 17, 4304–4311, 1978.

    Article  PubMed  CAS  Google Scholar 

  21. Pepys, M.B., Dash, A.C., Markham, R.E. et al. Clin. Exp. Immunol. 32, 119–124, 1978.

    PubMed  CAS  Google Scholar 

  22. Strachan, A.F. & Johnson, P.M. J. Clin. Lab. Immunol. 8, 153–156, 1982.

    PubMed  CAS  Google Scholar 

  23. Jensson, O., Bjomsson, G., Amason, A. et al. Acta Med. Scand. 211, 341–345, 1982.

    Article  PubMed  CAS  Google Scholar 

  24. Sipe, J.D. & Cohen, A.S. Fed. Proc. 41, 4985, 1982.

    Google Scholar 

  25. Skinner, M., Vaitukaitis, J.L., Cohen, A.S. & Benson, M.D. J. Lab. Clin. Med. 94, 633–638, 1979.

    PubMed  CAS  Google Scholar 

  26. Levo, Y, Shalit, M. & Tur-Kaspa, R. Am. J. Gastroenterol. 77, 427–430, 1982.

    PubMed  CAS  Google Scholar 

  27. Pepys, M.B., Baltz, M.L., Gomer, K. et al. Nature 278, 259–261, 1979.

    Article  PubMed  CAS  Google Scholar 

  28. Le P.T., Muller, M.T. & Mortensen, R.F. J. Immunol. 129, 665–672, 1982.

    PubMed  CAS  Google Scholar 

  29. Mortensen, R.T., Beisel, K., Zeleznik, N.J. & Le, P.T. J. Immunol. 129, 385–430, 1983.

    Google Scholar 

  30. Skinner, M., Cathcart, E.S., Cohen, A.S. & Benson, M.D. J. Exp. Med. 140, 871–876, 1974.

    Article  PubMed  CAS  Google Scholar 

  31. Skinner, M., Shirahama, T., Cohen, A.S. & Deal, C.L. Prep. Biochem. 12, 461–476, 1983.

    Article  Google Scholar 

  32. Dyck, R.F., Lockwood, C.M., Kershaw, M. et al. J. Exp. Med. 152, 1162–1174, 1980.

    Article  PubMed  CAS  Google Scholar 

  33. Inoue, S., Leblond, C.P. & Laurie, G.W. J. Cell. Biol. 97, 1524–1537, 1983.

    Article  PubMed  CAS  Google Scholar 

  34. Inoue, S., Skinner, M., Leblond, C.P. et al. Biochem. Biophys. Res. Commun. 134, 995–999, 1986.

    Article  PubMed  CAS  Google Scholar 

  35. DeBeer, F.C., Baltz, M., Holford, S. et al. J. Exp. Med. 154, 1134–1139, 1981.

    Article  CAS  Google Scholar 

  36. Hutchcraft, C.L., Gewürz, H., Hansen, B. et al. J. Immunol. 126, 1217–1219, 1981.

    PubMed  CAS  Google Scholar 

  37. Pepys, M.B., Dyck, R.F., DeBeer, F.C. et al. Clin. Exp. Immunol. 38, 284–293, 1979.

    PubMed  CAS  Google Scholar 

  38. Hind, C.R.K., Collins, P.M., Renn, D. et al. J. Exp. Med. 159, 1058–1069, 1984.

    Article  PubMed  CAS  Google Scholar 

  39. Hind, C.R.K., Collins, P.M., Caspi, D. et al. Lancet 2, 376–378, 1984.

    Article  PubMed  CAS  Google Scholar 

  40. Hind, C.R.K., Collins, P.M., Baltz, M.L. & Pepys, M.B. Biochem. J. 225, 107–111, 1985.

    PubMed  CAS  Google Scholar 

  41. Potempa, L.A., Kubak, B.M. & Gewürz, H. J. Biol. Chem. 260, 12142–12147, 1985.

    PubMed  CAS  Google Scholar 

  42. Skinner, M., Talarico, L., Cohen, A.S. & St. John, A. In Amyloid and Amyloidosis. Glenner, G.G., Costa, P.P., Freitas, A.F., Eds. Excerpta Medica, Amsterdam, 361–365, 1980.

    Google Scholar 

  43. Rubinow, A., Skinner, M. & Cohen, A.S. Circulation 63, 1285–1288, 1981.

    Article  PubMed  CAS  Google Scholar 

  44. Gertz, M., Skinner, M., Connors, L.H. et al. Am. J. Cardiol. 55, 1646, 1985.

    Article  PubMed  CAS  Google Scholar 

  45. Skinner, M., Stone, P., Shirahama, T. et al. Proc. Soc. Exp. Biol. Med. 181, 211–214, 1986.

    PubMed  CAS  Google Scholar 

  46. Pras, M., Schubert, M., Zucker-Franklin, D. et al. J. Clin. Invest. 47, 924–933, 1968.

    Article  PubMed  CAS  Google Scholar 

  47. Skinner, M. & Cohen, A.S. Methods in Enzymology, 1986, (In press).

    Google Scholar 

  48. Gertz, M.A., Skinner, M., Cohen, A.S. & Kyle, R.A. J. Lab. Clin. Med. 102, 773–778, 1983.

    PubMed  CAS  Google Scholar 

  49. Laurell, C.B. Scand. J. Clin. Lab. Invest. 29 (suppl. 124), 21–37, 1972.

    Article  CAS  Google Scholar 

  50. Shirahama, T., Skinner, M., Sipe, J.D. & Cohen, A.S. Virchows Archiv (Cell Path.) 48, 197–206, 1985.

    Article  CAS  Google Scholar 

  51. Yood, R.A., Skinner, M., Cohen, A.S. & Lee, V.W. J. Rheumatol. 8, 760–766, 1981.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Thorndike Memorial Laboratory and Division of Medicine, Boston City Hospital, Boston, MA, 02118, USA

    Martha Skinner, Tsuranobu Shirahama & Alan S. Cohen

  2. The Arthritis Center, Boston University School of Medicine, Boston, MA, 02118, USA

    Martha Skinner, Tsuranobu Shirahama & Alan S. Cohen

Authors
  1. Martha Skinner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tsuranobu Shirahama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Alan S. Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Div of Immunochemistry, University Hospital Groningen, 59 Oostersingel, 9713 EZ, Groningen, The Netherlands

    Jan Marrink Ph.D.

  2. Department of Internal Medicine, Div of Rheumatology, University Hospital Groningen, Oostersingel 59, 9713 EZ, Groningen, The Netherlands

    Martin H. Van Rijswijk M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Martinus Nijhoff Publishers, Dordrecht

About this chapter

Cite this chapter

Skinner, M., Shirahama, T., Cohen, A.S. (1986). Amyloid P-Component: Clinical Implications. In: Marrink, J., Van Rijswijk, M.H. (eds) Amyloidosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4309-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-4309-4_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8415-4

  • Online ISBN: 978-94-009-4309-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation