Abstract
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is the prototype for certain isomers from several classes of halogenated aromatic compounds, including the polychlorinated biphenyls (Goldstein, 1980; Poland et al., 1979). Studies carried out in inbred murine strains have shown that the induction of cytochrome P1-450 and other xenobiotic metalbolizing enzymes by TCDD is regulated by a genetic locus (designated the Ah locus) (reviewed in Poland and Knutson, 1982; Nebert and Jensen, 1979). It has been postulated (Nebert et al., 1984; Poland et al., 1979), that the Ah locus codes for a receptor Protein (to be designated in this report as the Ah receptor). The Ah receptor originally was identified in murine liver (Poland et al., 1976) and subsequently has been detected in several epithelial tissues (Glasiewicz, 1983) and animal (Guenthner and Nebert, 1977) and human (Hudson et al., 1983) cells in culture. In mice this receptor has been shown to be involved in two toxic responses to TCDD: epidermal hyperplasia (Knutson and Poland, 1982) and thymic atrophy (Poland and Glover, 1980; see below). The actions of TCDD on targets such as the skin and thymus appear to result in altered patterns of growth and differentiation (reviewed in Greenlee and Neal, 1985).
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Greenlee, W.F., Dold, K.M., Osborn, R. (1987). An In Vitro Model for Studying Cellular and Molecular Mechanisms of Thymic Atrophy Induced by Chlorinated Aromatic Compounds. In: Berlin, A., Dean, J., Draper, M.H., Smith, E.M.B., Spreafico, F. (eds) Immunotoxicology. Developments in Hematology and Immunology, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4307-0_13
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