Abstract
The lymphoid tissue can be structurally divided in to primary and secondary lymphoid organs or tissues. In the primary organs, the antigen-independent proliferation of lymphocytes takes place. Generation of T-lymphocytes from stem cells occurs in the thymus. In birds, the bursa of Fabricius has been shown to be the primary organ that supports extensive lymphopoiesis of B cells (the mammalian equivalent of the bursa of Fabricius may exist in different sites, e.g. the bone marrow or as suggested by Hall in this volume, in the lower gut) The secondary lymphoid tissue, in which the complex cellular interactions take place which form the basis of the immune response, includes the spleen, lymph nodes and the mucosa associated lymphoid tissues in the alimentary and respiratory tracts.
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© 1987 ECSC, EEC, EAEC, Brussels-Luxembourg and WHO, Geneva
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Vos, J.G. (1987). The Role of Histopathology in Assessment of Immunotoxicity. In: Berlin, A., Dean, J., Draper, M.H., Smith, E.M.B., Spreafico, F. (eds) Immunotoxicology. Developments in Hematology and Immunology, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4307-0_11
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DOI: https://doi.org/10.1007/978-94-009-4307-0_11
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