Abstract
Adequate treatment of malignant melanoma places medical science before a difficult problem. Disseminated melanomas have poor prognoses. Moreover malignant melanomas are known to be radioresistant to a high degree. Recent investigations, however, cast doubt on this notorious reputation (1). It has been proposed that a high radiation dose per fraction, rather than total dose, may be a critical factor in the treatment of melanomas by means of irradiation (2,3).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Trott KR, Von Lieven H, Kummermehr J, Skopal D, et al, The radiosensitivity of malignant melanomas. Part I. Experimental studies. Int. J. Radiat. Oncol. Biol. Phys. 7:9, 1981.
Habermalz HF, Fisher JJ, Radiation therapy of malignant melanoma. Experience with high individual treatment dose. Cancer 38:2258, 1976.
Hornsey S, The relationship between total dose, number of fractions and fraction size in the response of malignant melanoma in patients. Brit. J. Radiol. 51:905, 1978.
Van Langevelde A, Bakker CNM, Broxterman HJ, Journée-de Korver JG, et al, Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivates. Eur. J. Nucl. Med. 8:45, 1983.
Larsson B, Olander K, Dencker L, Holmquist L, Accumulation of 125-I-labelled thiouracil and propylthiouracil in marine melanotic melanomas. Brit. J. Cancer 46:538, 1982.
Fairchild RG, Packer S, Greenberg D, Som P, et al, Thiouracil distribution in mice carrying transplantable melanoma. Cancer Res. 42:5126, 1982.
Watts KP, Fairchild RG, Slatkin DN, Greenberg D, et al, Melanin content of hamster tissues, human tissues, and various melanomas. Cancer Res. 41:467, 1981.
Broxterman HJ, Van Langevelde A, Bakker CNM, Boer H, et al, Incorporation of (125-I)-5-iodo-2-thiouracil in cultured hamster, rabbit, and human melanoma cells. Cancer Res. 43:1316, 1983.
Packer S, Lambrecht RM, Cristman DR, Azzizullah N, et al, Metal isotopes used as radioactive indicators of ocular melanoma. Amer. J. Ophtal. 83:80, 1977.
Wick MM, Inhibition of clonogenic growth of melanoma cells by combination of melanocyte stimulating hormone and theophylline. J. invest. Derm. 77:253, 1981.
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, Protein measurements with the folin phenol reagent. J. biol. Chem. 193:265, 1951.
Camiener GW, Smith CG, Studies on the enzymatic deamination of cytosine arabinoside I. Enzymatic distribution and species specificity. Biochem. Pharmacol. 14:1405, 1965.
Camiener GW, Studies on the enzymatic deamination of cytosine arabinoside II. Properties of the deaminase of human liver. Biochem. Pharmacol. 16:1681, 1967.
Cheng YC, Capizzi RL, Enzymology of cytosine arabinoside. Med. Pediat. Oncol. 10(suppl.1):27, 1982.
Sawyer TK, Sanfilippo PJ, Hruby VJ, Engel MH, 4-Norleucine,7-D-phenylanaline-α-melanocyte-stimulating hormone: A highly potent α-melanotropin with ultralong biological activity. Proc. nat. Acad. Sci, USA 77:5754, 1980.
Dencker L, Larsson B, Olander K, Ullberg S, et al, False precursors of melanin as selective melanoma seekers. Brit. J. Cancer 39:449, 1979.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
van der Plas, J., van Langevelde, A., Oosterhuis, J.A., Pauwels, E.K.J. (1986). Iodine Labelled 5-Iodo-2-Thiouracil as a Melanoma Seeking Agent: A Potential Drug for Diagnosis and Treatment. In: Cox, P.H., Mather, S.J., Sampson, C.B., Lazarus, C.R. (eds) Progress in Radiopharmacy. Developments in Nuclear Medicine, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4297-4_8
Download citation
DOI: https://doi.org/10.1007/978-94-009-4297-4_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8410-9
Online ISBN: 978-94-009-4297-4
eBook Packages: Springer Book Archive