Myocardial release of hypoxanthine and lactate during coronary angioplasty: A quickly reversible phenomenon, but for how long?

  • Patrick W. Serruys
  • Federico Piscione
  • William Wijns
  • Johan A. J. Hegge
  • Eef Harmsen
  • Marcel van den Brand
  • Pim de Feyter
  • Paul G. Hugenholtz
  • Jan W. De Jong
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 58)


Until recently the assessment of alteration in myocardial metabolism in man early after an abrupt occlusion of a major coronary artery has not been feasible. Percutaneous transluminal coronary angioplasty (PTCA), however, now provides a unique opportunity to study the time course of these metabolic changes during the transient interruption of coronary flow by the balloon occlusion sequence in patients with single-vessel disease and without angiographically demonstrable collateral circulation [1, 2]. The need to detect any persisting metabolic or mechanical dysfunction becomes of even greater concern as the number of dilated vessels and the duration of balloon inflation tend to increase, thereby enhancing both the extent and the severity of ischemia. The risk exists that the damage induced by the intervention may exceed its benefit.


Coronary Sinus Coronary Occlusion Reactive Hyperemia Balloon Inflation Occlusion Pressure 
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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • Patrick W. Serruys
  • Federico Piscione
  • William Wijns
  • Johan A. J. Hegge
  • Eef Harmsen
  • Marcel van den Brand
  • Pim de Feyter
  • Paul G. Hugenholtz
  • Jan W. De Jong

There are no affiliations available

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