Abstract
Idiotypes are phenotypic markers of V region genes encoding the specificity of two polypeptide chains which constitute the antigen receptor of T or B lymphocytes. Two categories of idiotopes are expressed on the immune receptor of lymphocytes. Individual idiotypes are clonotypic antigenic determinants expressed only by a single clone. These idiotypes results from somatic recombination or somatic mutational events. Generally, they are not inherited. A second category is represented by cross-reactive idiotypes, shared by clones exhibiting the same antigen specificity as well as by some with different antigen specificities. These idiotypes are antigenic markers of V germline genes since they are expressed by the majority or all individuals of an inbred strain or of a species. The idiotypes, as antigenic markers, can elicit a humoral or cellular immune response not only in xenogeneic or allogeneic animals, but also in syngeneic or even autologous systems.
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© 1986 Martinus Nijhoff Publishers, Dordrecht
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Bona, C.A. (1986). Regulatory Idiotopes and Diseases. In: Ponticelli, C., Minetti, L., D’Amico, G. (eds) Antiglobulins, cryoglobulins and glomerulonephritis. Developments in Nephrology, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4289-9_4
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DOI: https://doi.org/10.1007/978-94-009-4289-9_4
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