DNA Rearrangements as Unique Markers of Clonal Evolution, Recurrence and Translocation
In the past several years, molecular biologic techniques have been applied to complement immunologic methodologies in defining lineage, clonality and differentiation of lymphoproliferative diseases. In addition to these insights, molecular characterization of lymphoid cells has provided a sensitive way to detect small populations of clonal cells. This is of particular importance in diseases such as pre-B acute lymphoblastic leukemia (ALL), in which tumor-specific surface markers have not been identified.1
KeywordsGene Rearrangement Cell Antigen Receptor Immunoglobulin Gene Rearrangement Chain Gene Rearrangement Clonal Cell Population
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