DNA Rearrangements as Unique Markers of Clonal Evolution, Recurrence and Translocation

  • J. J. Wright
  • D. G. Poplack
  • A. Bakhshi
  • S. J. Korsmeyer
Part of the Developments in Oncology book series (DION, volume 45)


In the past several years, molecular biologic techniques have been applied to complement immunologic methodologies in defining lineage, clonality and differentiation of lymphoproliferative diseases. In addition to these insights, molecular characterization of lymphoid cells has provided a sensitive way to detect small populations of clonal cells. This is of particular importance in diseases such as pre-B acute lymphoblastic leukemia (ALL), in which tumor-specific surface markers have not been identified.1


Gene Rearrangement Cell Antigen Receptor Immunoglobulin Gene Rearrangement Chain Gene Rearrangement Clonal Cell Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • J. J. Wright
  • D. G. Poplack
  • A. Bakhshi
  • S. J. Korsmeyer

There are no affiliations available

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