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Activated RAS Oncogenes in Acute Leukemia

  • J. L. Bos
  • M. Verlaan-de Vries
  • A. J. van der Eb
  • R. Delwel
  • B. Löwenberg
  • S. J. Roodenhuis
  • J. W. G. Janssen
  • L. P. Colly
Part of the Developments in Oncology book series (DION, volume 45)

Abstract

Of the 20–30 oncogenes presently known, the ras genes belong to the best studied genes that are thought to play a role in carcinogenesis (Weinberg, 1984). The ras family consists of 3 members the H-ras, K-ras and N-ras genes. They encode homologous proteins of 21kD whose cellular location is at the inner surface of the plasma membrane (Land et al., 1983b; Cooper, 1983). The 21kD H-ras protein has been found to bind guanine nucleotides and to exhibit GTPase activity (McGrath et al., 1984; Sweet et al., 1984). In this respect, the protein resembles the “G proteins”, which are known to be involved in the transduction of the receptor-mediated external signals into the cell. Recently, it was found that cells when injected with ras-specific monoclonal antibodies which presumably inactivate the H-ras protein cannot enter the S-phase of the cell cycle, this suggests that the H-ras protein plays an essential role in the G1 phase (Mulcahy et al., 1985).

Keywords

Acute Myeloid Leukemia Acute Lymphoid Leukemia Acute Promyelocytic Leukemia Cell Line Promyelocytic Leukemia Cell Line HL60 Haploid Genome Copy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albino AP: Le Strange R: Oliff AI: Furth ME: Old LJ: Nature 308(1984)69–72.PubMedCrossRefGoogle Scholar
  2. Balmain A: Pragnell IB: Nature 303(1983)72–75.PubMedCrossRefGoogle Scholar
  3. Balmain A: Ramsden M: Bowden: GT: Smit J: Nature 307(1984)658–661.PubMedCrossRefGoogle Scholar
  4. Bos JL: Verlaan-de Vries M: Jansen AM: Veeneman GH: Van Boom JH: Van der Eb AJ: Nucl.Acids Res. 12(1984)9155–9163.PubMedCrossRefGoogle Scholar
  5. Bos JL: Toksoz D: Marshall CJ: Verlaan-de Vries M: Veeneman GH: Van Van der Eb AJ: Van Boom JH: Janssen JWG: Steenvoorden ACM: Nature 315(1985)726–730.PubMedCrossRefGoogle Scholar
  6. Connor BJ: Reyes AA: Morin C: Itakura K: Teplitz RL: Wallace RB: Proc.Natl.Acad.Sci.USA 80(1983)278–282.CrossRefGoogle Scholar
  7. Cooper GM: Science 218(1983)801–807.Google Scholar
  8. Fasano O: Aldrich T: Tamanoi F: Taparowsky E: Furth M: Wigler M: Proc.Natl.Acad.Sci.USA 81(1984)4008–4012.PubMedCrossRefGoogle Scholar
  9. Guerrero I: Villasante A: Corces V: Pellicer A: Science (1984)1159–1162.Google Scholar
  10. Kelly K: Cochran BM: Stiles CD: Leder P: Cell 35(1983)603–608.PubMedCrossRefGoogle Scholar
  11. Land H: Parada LF: Weinberg RA: Nature 304(1983a)596–602.PubMedCrossRefGoogle Scholar
  12. Land H: Parada LF: Weinberg RA: Science 222(1983b)771–778.PubMedCrossRefGoogle Scholar
  13. McGrath JP: Capon DJ: Goeddel DV: Levinson AD: Nature 310(1984)644–649.PubMedCrossRefGoogle Scholar
  14. Mulcahy LS: Smith MR: Stacey DW: Nature 313(1985)241–243.PubMedCrossRefGoogle Scholar
  15. Ruley HE: Nature 304(1983)602.PubMedCrossRefGoogle Scholar
  16. Sukumar S: Notario V: Martin-Zanka D: Barbacid M: Nature 306(1983)658–661.PubMedCrossRefGoogle Scholar
  17. Sukumar S: Pulciani S: Doniger J: DiPaolo JA: Evans CH: Zbar B: Barbacid M: Science 223(1984)1197–1199.PubMedCrossRefGoogle Scholar
  18. Sweet RW: Yokoyama S: Kamata T: Feramisco JR: Rosenberg M: Gross M. Nature 311(1984)273–275.PubMedCrossRefGoogle Scholar
  19. Tainsky MA: Cooper CS: Giovanella BC: Vande Woude GF: Science 223(1984)643–645.CrossRefGoogle Scholar
  20. Varmus HE: Ann.Rev.Genet. 18(1984)560–612.CrossRefGoogle Scholar
  21. Weinberg RA: Blood 64(1984)1143–1145.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • J. L. Bos
    • 1
  • M. Verlaan-de Vries
    • 1
  • A. J. van der Eb
    • 1
  • R. Delwel
    • 2
  • B. Löwenberg
    • 2
  • S. J. Roodenhuis
    • 3
  • J. W. G. Janssen
    • 3
  • L. P. Colly
    • 4
  1. 1.Sylvius LaboratoriesLeidenThe Netherlands
  2. 2.Dr. Daniel den Hoed Cancer CenterRotterdamThe Netherlands
  3. 3.Netherlands Cancer InstituteAmsterdamThe Netherlands
  4. 4.Division HematologyAcademic HospitalLeidenThe Netherlands

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