Activated RAS Oncogenes in Acute Leukemia
Of the 20–30 oncogenes presently known, the ras genes belong to the best studied genes that are thought to play a role in carcinogenesis (Weinberg, 1984). The ras family consists of 3 members the H-ras, K-ras and N-ras genes. They encode homologous proteins of 21kD whose cellular location is at the inner surface of the plasma membrane (Land et al., 1983b; Cooper, 1983). The 21kD H-ras protein has been found to bind guanine nucleotides and to exhibit GTPase activity (McGrath et al., 1984; Sweet et al., 1984). In this respect, the protein resembles the “G proteins”, which are known to be involved in the transduction of the receptor-mediated external signals into the cell. Recently, it was found that cells when injected with ras-specific monoclonal antibodies which presumably inactivate the H-ras protein cannot enter the S-phase of the cell cycle, this suggests that the H-ras protein plays an essential role in the G1 phase (Mulcahy et al., 1985).
KeywordsAcute Myeloid Leukemia Acute Lymphoid Leukemia Acute Promyelocytic Leukemia Cell Line Promyelocytic Leukemia Cell Line HL60 Haploid Genome Copy
Unable to display preview. Download preview PDF.