Problems and Prospect of Histoincompatible Bone Marrow Transplantation Studied in Rhesus Monkeys

  • G. Wagemaker
Part of the Developments in Oncology book series (DION, volume 45)


Allogeneic bone marrow transplantation is a demonstrated effective therapy for a variety of congenital and acquired diseases of the lympho-hemopoietic system (1). Nevertheless, the possible immunological complications, which are graft rejection and graft-versus-host disease (GvHD), result in risks that counterbalance for many diseases the possible benefit for the patients, even if an HLA-identical family donor is available. For this reason, bone marrow transplantation is as yet restricted to diseases with a poor prognosis if treated otherwise.


Bone Marrow Transplantation Rhesus Monkey Median Survival Time Acute GvHD Hemopoietic Stem Cell 
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© Martinus Nijhoff Publishers, Dordrecht 1986

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  • G. Wagemaker

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