Detection and Selective Destruction of Tumor Cells by the Lipophilic Dye, Merocyanine 540

  • Fritz Sieber
Part of the Developments in Oncology book series (DION, volume 45)


Most cells undergo some interactions with their environment where the involvement of specialized surface structures has been demonstrated or is at least suspected. The recognition of soluble and cellular antigens by cells of the immune system, the binding of growth factors by cell surface receptors, the formation of neuromuscular junctions, the invasion of tissues by tumor cells, the homing of migrating and metastasizing cells, the formation of patterns during embryonic development, and contact inhibition of movement and growth are instructive examples. It is, therefore, not unreasonable to speculate that the plasma membrane characterizes like a fingerprint each cell with regard to cell type, functional activity, age, position in the cell cycle, and state of differentiation and transformation. Rather than being characterized by one qualitatively unique surface structure (“differentiation antigen” or “tumor antigen”) the postulated fingerprints may consist of unique combinations of quantitative differences in several plasma membrane components.


Membrane Fluidity Residual Tumor Cell Marrow Graft Bone Marrow Graft L1210 Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Martinus Nijhoff Publishers, Dordrecht 1986

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  • Fritz Sieber

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