Abstract
Most cells undergo some interactions with their environment where the involvement of specialized surface structures has been demonstrated or is at least suspected. The recognition of soluble and cellular antigens by cells of the immune system, the binding of growth factors by cell surface receptors, the formation of neuromuscular junctions, the invasion of tissues by tumor cells, the homing of migrating and metastasizing cells, the formation of patterns during embryonic development, and contact inhibition of movement and growth are instructive examples. It is, therefore, not unreasonable to speculate that the plasma membrane characterizes like a fingerprint each cell with regard to cell type, functional activity, age, position in the cell cycle, and state of differentiation and transformation. Rather than being characterized by one qualitatively unique surface structure (“differentiation antigen” or “tumor antigen”) the postulated fingerprints may consist of unique combinations of quantitative differences in several plasma membrane components.
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References
Shinitzky M: Membrane Fluidity and Cellular Functions. In: M Shinitzky (ed): Physiology of Membrane Fluidity, Vol 1, pp 1–51. Boca Raton: CRC Press, 1984.6
Cooper RA, and Strauss JF: Regulation of Cell Membrane Cholesterol. In: M Shinitzky (ed): Physiology of Membrane Fluidity, Vol. 1, pp 73–97. Boca Raton: CRC Press, 1984.
De Laat SW, Bluemink JG, Boonstra J, Mummery CL, van der Saag PT, and van Zoelen EJJ: Membrane Fluidity in Growth and Differentiation; The Neuroblastoma Cell Model. In: M Shinitzky (ed): Physiology of Membrane Fluidity, Vol 2, pp 21–51. Boca Raton: CRC Press, 1984.
Van Blitterswijk WJ: Alterations in Lipid Fluidity in the Plasma Membrane of Tumor Cells. In: M Shinitzky (ed): Physiology of Membrane Fluidity, Vol 2, pp 53–83. Boca Raton: CRC Press, 1984.
Kumar A, and Gupta CM: Red Cell Membrane Abnormalities in Chronic Myeloid Leukaemia. Nature 303: 632–633, 1983.
Humphries GMK, and Lovejoy JP: Dansyl Lysine: A Structure-Selective Fluorescent Membrane Stain. Biophys J 42: 307–310, 1983.
Humphries GMK, and Lovejoy JP: Cholesterol-Free Phospholipid Domains May Be the Membrane Feature Selected by NE-Dansyl-L-Lysine and Merocyanine 540. Biochem Biophys Res Commun 111: 768–774, 1983.
Valinsky JE, Easton TG, and Reich E: Merocyanine 540 as a Fluorescent Probe of Membranes: Selective Staining of Leukemic and Immature Hemopoietic Cells. Cell 13: 487–499, 1978.
Waggoner A: Optical Probes of Membrane Potential. J Membr Biol 27: 317–334, 1976.
Waggoner AS:Dye Indicators of Membrane Potential. Ann Rev Biophys Bioeng 8: 47–68, 1979.
Easton TG, Valinsky JE, and Reich E: Merocyanine 540 as a Fluorescent Probe of Membranes: Staining of Electrically Excitable Cells. Cell 13: 475–486, 1978.
Valinsky J, Reich E, Haghbin M, Slankard-Chahinian M, Ohnuma T, and Holland J: Merocyanine 540 Staining of Peripheral Leukocytes from Leukemic Remission Patients. Blood 54: 294, 1978.
Valinsky J, and Reich E: Merocyanine 540: A Useful Stain for Hemopoietic and Leukemic Cells. In: N Le Douarin (ed): Cell Lineage, Stem Cells and Cell Determination, pp 373–376. Amsterdam: Elsevier-North Holland Biomedical Press, 1979.
McClasky J, and Hoffman R: Photolysis of Human Leukemia Cells Stained with the Fluorescent Dye Merocyanine 540. Clin Res 29: 439A, 1981.
Schlegel RA, Phelps BM, Cofer GP, and Williamson P: Enucleation Eliminates a Differentiation-Specific Surface Marker from Normal and Leukemic Murine Erythroid Cells. Exp Cell Res 139: 321–328, 1982.
Reed JA, Kough RH, Williamson PL, and Schlegel RA: Merocyanine 540 Recognizes Membrane Abnormalities of Erythrocytes in Chronic Myelogenous Leukemia. Cell Biol Int Reports 9: 43–49, 1985
Schlegel RA, Phelps BM, Waggoner A, Terada L, and Williamson P: Binding of Merocyanine 540 to Normal and Leukemic Erythroid Cells. Cell 20: 321–328, 1980.
Williamson P, Mattocks K, and Schlegel RA: Merocyanine 540, a Fluorescent Probe Sensitive to Lipid Packing. Biochim Biophys Acta 732: 387–393, 1983.
Sieber F, Meagher RC, and Spivak JL: Differential Sensitivity of Mouse Hematopoietic Stem Cells to Merocyanine 540. Differentiation 19: 65–67, 1981
Meagher RC, Sieber F, and Spivak JL: Susceptibility to Merocyanine 540-Mediated Photosensitization: A Differentiation Marker on Murine Hematopoietic Progenitor Cells. J Cell Physiol 116: 118–124, 1983.
Sieber-Blum M, and Sieber F: Heterogeneity Amon Early Quail Neural Crest Cells. Develop Brain Res 14: 241–246, 1984.
Sieber F, and Sieber-Blum M: Dye-Mediated Photosensitization of Murine Neuroblastoma Cells. Submitted for publication.
Sieber F, Stuart RK, Sensenbrenner LL, and Sharkis SJ: Susceptibility to Merocyanine 540-Mediated Photolysis as a Differentiation Marker in Human Hematopoietic Stem Cells. Blood 58: 102a, 1981.
Myers CP, Kerk DK, and Norman A: Membrane Heterogeneity in Murine Stem Cells. In: SJ Baum, GD Ledney, and DW van Bekkum (eds): Experimental Hematology Today, pp 317–326. New York: Karger, 1980.
Sieber F, Stuart RK, Sensenbrenner LL, Sharkis SJ, and Spivak JL: Merocyanine 540-Mediated Photosensitization Preferentially Inhibits in vitro Colony Formation by two Human Leukemia Cell Lines. Clin Res 30: 331A, 1982.
Sieber F, Spivak JL, and Sutcliffe AM: Selective Killing of Leukemic Cells by Merocyanine 540-Mediated Photosensitization. Proc Natl Acad Sci USA 81: 7584–7587, 1984.
Sieber F: Merocyanine 540-Mediated Photosensitization of Leukemia and Solid Tumor Cells. In: R Rein (ed): Molecular Basis of Cancer, pp 227–234. New York: Alan R Liss, 1985.
Sieber F, Rao S, Rowley SD, and Sieber-Blum M: Selective Photosensitization of Human Neuroblastoma Cells: Implications for Autologous Bone Marrow Transplantation. Blood, in press.
Sieber F, Hilton J, and Colvin OM: Photodynamic Therapy of Drug-Resistant Tumors. Exp Hematol 12: 423, 1984.
Manna A, and Sieber F: Cell-cycle Specificity of Merocyanine 540-Mediated Photosensitization. Int J Cell Cloning, in press.
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© 1986 Martinus Nijhoff Publishers, Dordrecht
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Sieber, F. (1986). Detection and Selective Destruction of Tumor Cells by the Lipophilic Dye, Merocyanine 540. In: Hagenbeek, A., Löwenberg, B. (eds) Minimal Residual Disease in Acute Leukemia 1986. Developments in Oncology, vol 45. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4273-8_26
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DOI: https://doi.org/10.1007/978-94-009-4273-8_26
Publisher Name: Springer, Dordrecht
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