Double Autografting: A Potential Curative Regimen for Acute Leukaemia?
The conditioning regime used for allogeneic bone marrow transplantation in acute leukaemia has two functions: firstly to serve as immunosuppressive therapy to prevent rejection of the allogeneic marrow and secondly to eradicate host disease. The conditioning regimen most commonly used is TBI given as a single dose or in fractions to a total dose of 9–12 Grays together with cyclophosphamide 60mg/kg on two consecutive days as pioneered by the Seattle transplant unit, (Thomas et al, 1975).
KeywordsComplete Remission Acute Myeloid Leukaemia Acute Lymphoblastic Leukaemia Acute Leukaemia Allogeneic Bone Marrow Transplantation
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