Biologic and Treatment Determinants of Curability in Acute Myelogenous Leukemia

  • Michael J. Keating
  • Kenneth B. McCredie
  • Emil J. Freireich
Part of the Developments in Oncology book series (DION, volume 45)


Acute leukemia was the first malignancy to which the principles of adjuvant therapy were applied. In contrast to adjuvant treatment of solid tumors in which surgery and radiation therapy are usually followed by chemotherapy, hematologists used chemotherapy regimens to treat the presenting disease and render the patient free of identifiable tumor (complete remission) then continue to apply post-remission chemotherapy in an adjuvant setting. The response to chemotherapy before surgery and radiation in many solid tumors predicts for duration of survival after radiation and surgery. Likewise, the quality of response to remission induction therapy predicts for duration of complete remission in adult AML.


Complete Remission Acute Leukemia Minimal Residual Disease Remission Duration Remission Induction Therapy 
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  1. 1.
    Keating MJ, McCredie KB, Bodey GP, Smith TL, Gehan EA, and Freireich EJ: Improved prospects for long-term survival in adults with acute myelogenous leukemia. J Am Med Assoc 248:2481–2486, 1982.CrossRefGoogle Scholar
  2. 2.
    Burke PJ: Principles of therapy of malignancy extrapolated from a rat model of leukemia to man. IN: Minimal Residual Disease in Acute Leukemia, Lowenberg B, and Hagenbeek A (eds.). pp. 97–109, 1984.Google Scholar
  3. 3.
    Keating MJ: Early identification of potentially cured patients with acute myelogenous leukemia: — A recent challenge. IN: Adult Leukemias, vol. 1, Bloomfield CI (ed.). pp. 237–263, 1982.Google Scholar
  4. 4.
    Freireich EJ, Bodey GP, Harris JE, and Hart JS: Therapy of acute granulocytic leukemia. Cancer Res 27:2573–2577, 1967.PubMedGoogle Scholar
  5. 5.
    Freireich EJ, Gehan EA, Speer JF, Heilbrun L, Smith TL, Bodey GP, et al.: The usefulness of multiple pretreatment patient characteristics for prediction of response and survival with adult acute leukemia. IN: Advances in the Biosciences: Workshops on Prognostic Factors in Human Acute Leukemia, Fliedner TM and Perry S (eds.). pp. 131–144, 1973.Google Scholar
  6. 6.
    Gehan EA, Smith TL, Freireich EJ, et al.: Prognostic factors in acute leukemia. Semin Oncol 3:271–282, 1976.PubMedGoogle Scholar
  7. 7.
    Keating MJ, Smith TL, McCredie KB, et al.: A four-year experience with anthracycline, cytosine arabinoside, vincristine, and prednisone combination chemotherapy in 325 adults with acute leukemia. Cancer 47:2779–2788, 1981.PubMedCrossRefGoogle Scholar
  8. 8.
    Keating MJ, Smith TL, Gehan EA, McCredie KB, Bodey GP, and Freireich EJ: A prognostic factor analysis for use in development of predictive models for response in adult acute leukemia. Cancer 50:457–465, 1982.PubMedCrossRefGoogle Scholar
  9. 9.
    Smith TL, Gehan EA, Keating MJ, and Freireich EJ: Prediction of remission in adult acute leukemia: Development and testing of predictive models. Cancer 50:466–472, 1982.PubMedCrossRefGoogle Scholar
  10. 10.
    Keating MJ, Smith TL, Gehan EA, McCredie KB, Bodey GP, Spitzer G, et al.: Factors related to length of complete remission in adult acute leukemia. Cancer 45:2017–2029, 1980.PubMedCrossRefGoogle Scholar
  11. 11.
    Keating MJ: Factors influencing disease free interval after achieving complete remission in acute leukemia. IN: Minimal Residual Disease in Acute Leukemia, Lowenberg B and Hagenbeek A (eds.). pp. 149–164, 1984.Google Scholar
  12. 12.
    Keating MJ, Cork A, Broach Y, Smith TL, Walters RS, McCredie KB, Trujillo J, and Freireich EJ: Toward a clinically relevant cytogenetic classification of acute myelogenous leukemia. Leukemia Research, in press.Google Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • Michael J. Keating
  • Kenneth B. McCredie
  • Emil J. Freireich

There are no affiliations available

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