In Vitro Colony Forming Cells of Acute Lymphoblastic Leukemia: Analysis of 24 Cases with Recombinant Interleukin 2 as Growth Stimulus

  • Ivo Touw
  • Willem Hofhuis
  • George van Zanen
  • Ruud Delwel
  • Bob Lowenberg
Part of the Developments in Oncology book series (DION, volume 45)


In vitro colony assays are considered promising techniques for the detection of clonogenic leukemia cells. It is thought that leukemia cells, giving rise to colony growth in vitro (L-CFU), contribute to the perpetual growth of the tumor in vivo. Therefore, L-CFU are regarded as relevant in vitro end points for evaluating the remission status of leukemias, and for assessing the efficacy of purging procedures applied to autologous marrow transplants.


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Colony Formation Terminal Deoxynucleotidyl Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • Ivo Touw
  • Willem Hofhuis
  • George van Zanen
  • Ruud Delwel
  • Bob Lowenberg

There are no affiliations available

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