In Vitro Colony Forming Cells of Acute Lymphoblastic Leukemia: Analysis of 24 Cases with Recombinant Interleukin 2 as Growth Stimulus
In vitro colony assays are considered promising techniques for the detection of clonogenic leukemia cells. It is thought that leukemia cells, giving rise to colony growth in vitro (L-CFU), contribute to the perpetual growth of the tumor in vivo. Therefore, L-CFU are regarded as relevant in vitro end points for evaluating the remission status of leukemias, and for assessing the efficacy of purging procedures applied to autologous marrow transplants.
KeywordsAcute Myeloid Leukemia Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Colony Formation Terminal Deoxynucleotidyl Transferase
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