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In Vitro Colony Forming Cells of Acute Lymphoblastic Leukemia: Analysis of 24 Cases with Recombinant Interleukin 2 as Growth Stimulus

  • Ivo Touw
  • Willem Hofhuis
  • George van Zanen
  • Ruud Delwel
  • Bob Lowenberg
Part of the Developments in Oncology book series (DION, volume 45)

Abstract

In vitro colony assays are considered promising techniques for the detection of clonogenic leukemia cells. It is thought that leukemia cells, giving rise to colony growth in vitro (L-CFU), contribute to the perpetual growth of the tumor in vivo. Therefore, L-CFU are regarded as relevant in vitro end points for evaluating the remission status of leukemias, and for assessing the efficacy of purging procedures applied to autologous marrow transplants.

Keywords

Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Colony Formation Terminal Deoxynucleotidyl Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Dicke KA, Spitzer G, Ahearn MJ: Colony formation in vitro by leukemic cells in acute myelogenous leukemia with phytohaemagglutinin as stimulating factor. Nature 259: 129–130, 1976.PubMedCrossRefGoogle Scholar
  2. 2.
    Buick RN, Till JE, Mc Culloch EA: Colony assay for proliferative blast cells circulating in myeloblastic leukaemia. Lancet i: 862–863, 1977.CrossRefGoogle Scholar
  3. 3.
    Löwenberg B, Swart K, Hagemeyer A: PHA-induced colony formation in acute non-lymphocytic and chronic myeloid leukemia. Leuk. Res. 4: 143–149, 1980.PubMedCrossRefGoogle Scholar
  4. 4.
    Izaguirre CA, Curtis J, Messner H, Mc Culloch EA: A colony assay for blast cell progenitors in non-B non T (common) acute lymphoblastic leukemia. Blood 57: 823–829, 1981.PubMedGoogle Scholar
  5. 5.
    Taetle R, Richardson D, To D, Royston I, Mendelsohn J: Colony-forming assay for circulating chronic lymphocytic leukemia cells. Leuk. Res. 6: 335–344, 1982.PubMedCrossRefGoogle Scholar
  6. 6.
    Izaguirre CA: Colony formation by lymphoid cells. Clin. Haematol. 13: 405–422, 1984.PubMedGoogle Scholar
  7. 7.
    Touw I, Delwel R, Bolhuis R, van Zanen G, Löwenberg B: Common and pre-B acute lymphoblastic leukemia cells express interleukin 2 receptors, and interleukin 2 stimulates in vitro colony formation. Blood 66: 556–561, 1985.PubMedGoogle Scholar
  8. 8.
    Touw I, Löwenberg B: Interleukin 2 stimulates chronic lymphocytic leukemia colony formation in vitro. Blood 66: 237–240, 1985.PubMedGoogle Scholar
  9. 9.
    Tsudo M, Uchiyama T, Uchino H: Expression of Tac antigen on activated normal human B cells. J. Exp. Med. 160: 612–617, 1984.PubMedCrossRefGoogle Scholar
  10. 10.
    Mingari MC, Gerosa F, Carra G, Accolla RS, Moretta A, Zubler RH, Waldmann TA, Moretta L: Human interleukin 2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells. Nature 312: 641–643, 1984.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • Ivo Touw
  • Willem Hofhuis
  • George van Zanen
  • Ruud Delwel
  • Bob Lowenberg

There are no affiliations available

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