Detection of Minimal Residual Acute Lymphoblastic Leukemia by Immunological Marker Analysis: Possibilities and Limitations

  • J. J. M. van Dongen
  • H. Hooijkaas
  • H. J. Adriaansen
  • K. Hahlen
  • G. E. van Zanen
Part of the Developments in Oncology book series (DION, volume 45)


The detection of small numbers of malignant cells is a major problem at diagnosis and during follow-up of malignancies (1). The possibilities and limitations of methods for the detection of minimal residual disease in general depend on their specificity (malignant cells have to be identified among many normal cells), sensitivity (detection limit of the method) and reproducibility. Although the method as such may have an excellent reproducibility, the cell sample may not always be representative for the whole cell population.


Acute Lymphoblastic Leukemia Minimal Residual Disease Terminal Deoxynucleotidyl Transferase Lymphoblastic Lymphoma Malignant Counterpart 
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© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • J. J. M. van Dongen
  • H. Hooijkaas
  • H. J. Adriaansen
  • K. Hahlen
  • G. E. van Zanen

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