New Possibilities for Cytogenetic Analysis of Leukemic Cells

  • A. Hagemeijer
  • H. J. Adriaansen
  • C. R. Bartram
Part of the Developments in Oncology book series (DION, volume 45)


The first cytogenetic aberration associated with leukemia has been reported more than 25 years ago, i.e. the Philadelphia (Ph) chromosome in chronic myeloid leukemia (CML) (1). At the present time, it appears that most, if not all cases of acute leukemia are characterized by cytogenetic changes which follow a non-random pattern of occurrence (2,3). Almost every month, a new translocation or chromosomal rearrangement is described as specifically associated with a subtype of leukemia with characteristic clinical, pathological and immunological features (Table I) (3–7). In contrast with the immunological markers which are differentiation markers that appear also on some normal cells, cytogenetic markers are unique and specific features of leukemic cells. It may be expected within a few years that a chromosomal classification of hematological malignancies will develop next to the FAB classification presently in use (8,9).


Chronic Myeloid Leukemia Acute Leukemia Minimal Residual Disease Acute Nonlymphocytic Leukemia Cellular Oncogene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • A. Hagemeijer
  • H. J. Adriaansen
  • C. R. Bartram

There are no affiliations available

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