The Pharmacology of Local Anesthetic Agents

  • B. G. Covino
Part of the Developments in Critical Care Medicine and Anesthesiology book series (DCCA, volume 11)


Chemical compounds that demonstrate local anesthetic activity usually possess the following chemical arrangement: Aromatic portion — Intermediate chain — Amine Portion


Local Anesthetic Agent Sodium Bisulfite Local Anesthetic Drug Lipid Solubility Intermediate Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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    Covino BG, Vassallo HG. 1976. Local Anesthetics: Mechanism of Action and Clinical Use. New York: Grune & Stratton.Google Scholar
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    DeJong RH. 1977. Local Anesthetics. 2nd ed. Springfield: Charles C. Thomas.Google Scholar
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    Scott DB, Cousins MJ. 1980. Clinical pharmacology of local anesthetic agents. In: Cousins MJ, Bridenbaugh PO, eds. Neural Blockade. Philadelphia, J.B. Lippincott Co.Google Scholar
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    Kotelko DM, Shnider SM, Dailey PA, Brizgys RV, Levinson G, Shapiro WA, Koike M, Rosen MA. 1984. Bupivacaine-induced cardiac arrhythmias in sheep. Anesthesiology 60:10–18.PubMedCrossRefGoogle Scholar
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    Covino BG. 1983. Potential neurotoxicity of local anesthetic agents. Can Anaesth Soc J 30:111–116.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1986

Authors and Affiliations

  • B. G. Covino

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