HLA-DR Antigen Expression and Autoimmunity

  • A. P. Weetman
Part of the Immunology and Medicine book series (IMME, volume 3)


Products of the major histocompatibility complex (MHC) of genes play several key roles in the autoimmune response. Besides being predominantly responsible for the rejection of tissue grafts and graft-versus-host reactions, molecules encoded by MHC genes are directly involved in the recognition of antigen by T-cells. The MHC also determines to a great extent whether or not a particular antigen will evoke an immune response. The chapter begins with a synopsis of MHC antigens and their involvement in the normal immune response, together with a review of the factors involved in antigen presentation. This is followed by a summary of the recent studies which show that a wide variety of cells, including those from endocrine tissues, may express MHC class II antigens, like HLA-DR, under certain conditions. In the last section, the possible consequences of this phenomenon are discussed with regard to endocrine autoimmunity.


Major Histocompatibility Complex Primary Biliary Cirrhosis Antigen Expression Thyroid Cell Alopecia Areata 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© MTP Press Limited 1986

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  • A. P. Weetman

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