Skip to main content
SpringerLink
Log in
Book cover

Immunoglobulins in Health and Disease pp 143–172Cite as

Monoclonal Immunoglobulins

  • Chapter

  • 65 Accesses

Part of the book series: Immunology and Medicine Series ((IMME,volume 1))

Abstract

Every immunoglobulin is the product of a single family or clone of plasma cells. Since almost all immunogenic substances have multiple antigenic sites, many different clones are involved in the specific antibody response, but each clone will synthesize and secrete a unique heavy and light chain variable region.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hobbs, J. R. (1971). Immunoglobulins in clinical chemistry. Adv. Clin. Chem., 14, 219–317

    Article  PubMed  CAS  Google Scholar 

  2. Warner, N. L., Potter, M. and Metcalf, D. (1974). Multiple myeloma and related immunoglobulin producing neoplasms. UICC Tech. Report Series, V13, 18–35

    Google Scholar 

  3. Kyle, R. A. (1984). ‘Benign’ monoclonal gammopathy. A misnomer? J. Am. Med. Assoc., 251, 1849–54

    Article  Google Scholar 

  4. DeFronzo, R. A., Cooke, C. R., Wright, J. R. and Humphrey, R. L. (1978). Renal function in patients with myeloma. Medicine (Baltimore), 57, 151–66

    Google Scholar 

  5. Hamblin, T. (1986). The kidney in myeloma. Br. Med. J., 292, 2–3

    Article  CAS  Google Scholar 

  6. Pruzanski, W. (1982). Unusual manifestations of plasma-cell dyscrasis. In Ritzmann, S. E. (ed.) Pathology of Immunoglobulins: Diagnostic and Clinical Aspects, pp. 325–82. ( New York: Alan R. Liss )

    Google Scholar 

  7. Durie, B. G. M. and Salmon, S. E. (1975). A clinical staging system for multiple myeloma. Cancer, 36, 842–54

    Article  PubMed  CAS  Google Scholar 

  8. Durie, B. and Salmon, S. E. (1982). The current status and future prospects of treatment for multiple myeloma. Clin. Haematol., 11, 181–210

    PubMed  CAS  Google Scholar 

  9. Kyle, R. A. (1984). Treatment of multiple myeloma. A small step forward? N. Engl. J. Med., 310, 1382–3

    Article  PubMed  CAS  Google Scholar 

  10. Carter, P. (1977). Monoclonal proteins. In Holborow, E. J. and Reeves, W. G. (eds.) Immunology in Medicine, pp. 957–97. ( London and New York: Academic Press )

    Google Scholar 

  11. Bergsagel, D. E. (1982). Plasma cell neoplasms and acute leukaemia. Clin. Haematol., 11, 221–34

    PubMed  CAS  Google Scholar 

  12. Kyle, R. A. (1983). Long term survival in multiple myeloma. N. Engl. J. Med., 308, 314–16

    Article  PubMed  CAS  Google Scholar 

  13. Selby, P. C., Peacock, M. and Marshall, D. H. (1984). Hypercalcaemia: management. Br. J. Hosp. Med., 31, 186–97

    PubMed  CAS  Google Scholar 

  14. Benson, W. J., Scarffe, J. H., Todd, I. D. H., Palmer, M. and Crowther, D. (1979). Spinal cord compression in myeloma. Br. Med. J., 1, 1541–4

    Article  PubMed  CAS  Google Scholar 

  15. MRC Working Party on Leukaemia in Adults. (1984). Analysis and management of renal failure in fourth MRC myelomatosis trial. Br. Med. J., 288, 1411–16

    Article  Google Scholar 

  16. Bataille, R. (1982). Localised plasmacytomas. Clin. Haematol., 11, 111–22

    Google Scholar 

  17. Sinclair, D., Dagg, J. H., Mowat, A. M., Parrott, D. M. V. and Stott, D. I. (1984). Serum paraproteins in chronic lymphocytic leukaemia. J. Clin. Pathol., 37, 463–6

    Article  PubMed  CAS  Google Scholar 

  18. Khojasteh, A., Haghshenass, M. and Haghighi, P. (1983). Immunoproliferative small intestinal disease. A ‘third-world lesion’. N. Engl. J. Med., 308, 1401–5

    Article  PubMed  CAS  Google Scholar 

  19. Ben-Basset, M., Boner, G., Rosefield, J., Pick, A. I., Kahana, M., Hazaz, B. and Hochman,B. (1983). The clinicopathologic features of cryoglobulinaemic nephropathy. Am. J. Clin. Pathol., 79, 147–56

    Google Scholar 

  20. Hind, C. R. K. and Pepys, M. B. (1984). Amyloidosis: classification and pathogenesis. Hosp. Update, 10, 593–8

    Google Scholar 

  21. Kyle, R. A. (1982). Amyloidosis. Clin. Haematol., 11, 151–80

    PubMed  CAS  Google Scholar 

  22. Ilyas, A. A., Quarles, R. H., Macintosh, T. D., Dobersen, M. J., Trapp, B. D., Dalakas, M. C. and Brady, R. O. (1984). IgM in a human neuropathy related to paraproteinaemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside. Proc. Natl. Acad. Sci., 81, 1225–9

    Article  PubMed  CAS  Google Scholar 

  23. Kelly, J. T., Kyle, R. A., O’Brien, P. C. and Dyck, P. J. (1981). Prevalence of monoclonal protein in peripheral neuropathy. Neurology, 31, 1480–3

    PubMed  Google Scholar 

  24. Gelfand, J. A., Boss, G. R., Conley, C. L., Reinhart, R. and Frank, M. M. (1979). Acquired CI esterase inhibitor deficiency and angioedema: a review. Medicine (Baltimore), 58, 321–8

    CAS  Google Scholar 

Download references

Authors
  1. M. Haeney
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Clinical Sciences Centre, Northern General Hospital, Sheffield, UK

    M. A. H. French

Rights and permissions

Reprints and permissions

Copyright information

© 1986 MTP Press Limited

About this chapter

Cite this chapter

Haeney, M. (1986). Monoclonal Immunoglobulins. In: French, M.A.H. (eds) Immunoglobulins in Health and Disease. Immunology and Medicine Series, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4169-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-4169-4_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8351-5

  • Online ISBN: 978-94-009-4169-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation