Abstract
During fetal life the control of gas exchange by the placenta is largely under maternal control1. The fetus responds to fluctuations in supply or demand of oxygen by chemoreflex modulation of regional blood flow1. The fetus thus makes active responses to fluctuations in blood gas tensions, but they are mediated almost entirely by cardiovascular adaptations. In contrast the adult responds to alterations of blood gas tensions by mechanisms which are almost entirely respiratory.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Abbreviations
- \(\dot VE\) :
-
Minute ventilation.
- QS:
-
Quiet sleep.
- REM:
-
Rapid eye movement sleep.
- \(\dot Q\) :
-
Cardiac output.
- T :
-
Transit time from lung to carotid body.
- VA:
-
Volume of the lung compartment.
References
Dawes, G. S., Duncan, S., Lewis, B. V., Merlet, C. L., Owen-Thomas, J. B. and Reeves, R. T. (1969). Hypoxaemia and aortic chemoreceptor functions in fetal lambs. J. Physiol., 201, 105–16
Haddad, G. G. and Mellins, R. B. (1984). Hypoxia and respiratory control in early life. Ann. Rev. Physiol., 46, 629–43
Walker, D. W. (1984). Peripheral and central chemoreceptors in the fetus and newborn. Ann. Rev. Physiol., 46, 687–703
Rigatto, H. (1984). Control of ventilation in the newborn. Ann. Rev. Physiol., 46, 661–74
Read, D. J. C. and Henderson-Smart, D. J. (1984). Regulation of breathing in the newborn during different behavioural states. Ann. Rev. Physiol., 46, 675–85
Cross, K. W. (1949). The respiratory rate and ventilation in the newborn baby. J. Physiol., 109, 459–74
Fleming, P. J., Levine, M. R. and Goncalves, A. (1982). Changes in respiratory pattern resulting from the use of a facemask to record respiration in newborn infants. Pediatr. Res., 16, 1031–4
Fleming, P. J., Levine, M. R., Goncalves, A. and Woollard, S. (1983). Barometric plethysmograph: advantages and limitations in recording infant respiration. J. Appl. Physiol., 55, 1924–31
Dufty, P., Spriet, L., Bryan, M. H. and Bryan, A. C. (1981). Respiratory inductance plethysmography (Respitrace): An evaluation of its use in the infant. Am. Rev. Respir. Dis., 123, 542–6
Phillipson, E. A. (1978). Respiratory adaptations during sleep. Ann. Rev. Physiol., 40, 133–56
Anders, T., Emde, R. and Parmelee, A. (1971). A Manual of Terminology, Techniques and Criteria for Scoring of States of Sleep and Wakefulness in Newborn Infants. UCLA Brain Information Service, BRI Publications Office, California
Prechtl, H. F. R. (1974). The behavioural states of the newborn infant (a review). Brain Res., 76, 1304–11
Hoppenbrouwers, T., Hodgman, J. E., Harper, R. M., Hofman, E., Sterman, M. B. and McGinty, D. J. (1977). Polygraphic studies of normal infants during the first 6 months of life. Ill: Incidence of apnea and periodic breathing. Pediatrics, 60, 418–25
Prechtl, H. F. R. and O’Brien, M. J. (1982). Behavioural states of the full-term newborn. The emergence of a concept. In Stratton, P. (ed.) Psychobiology of the Human Newborn, pp. 53–73 ( New York: Wiley )
Stefanski, M., Schulzek, K., Bateman, D., Kairam, R., Pedley, T. A., Masterson, J. and James, L. S. (1984). A scoring system for states of sleep and wakefulness in term and preterm infants. Pediatr Res., 18, 58–62
Haddad, G. G., Gandhi, M. R. and Mellins, R. B. (1982). Maturation of ventilatory response to hypoxia in puppies during sleep. J. Appl. Physiol., 52, 309–14
Baker, T. L. and McGinty, D. J. (1977). Reversal of cardiopulmonary failure during active sleep in hypoxic kittens: implications for sudden infant death. Science, 198, 419–21
Jeffrey, H. E. and Read, D. J. C. (1980). Ventilatory responses of newborn calves to progressive hypoxia in quiet and active sleep. J. Appl. Physiol., 48, 892–5
Tenney, S. M. and Ou, L. C. (1977). Ventilatory response of decorticate and decerebrate cats to hypoxia and CO2. Resp. Physiol. 29, 81–92
Darnall, R. A. (1983). The effect of opioid and adenosine antagonists on hypoxic ventilatory depression in the newborn piglet. Pediatr. Res., 17, 374A
DeBoeck, C., Reempts, P. V., Rigatto, H. and Chernick, V. (1983). Endorphins and the ventilatory depression during hypoxia in newborn infants. Pediatr. Res., 17, 374A
Blanco, C. E., Dawes, G. S., Hanson, M. A. and McCooke, H. B. (1984). The response to hypoxia of arterial chemoreceptors in fetal sheep and newborn lambs. J. Physiol., 351, 25–37
Blanco, C. E., Hanson, M. A. and McCooke, H. B. (1985). Studies in utero of the mechanism of chemoreceptor resetting. In Jones, C. J. (ed.) Physiological Development of the Fetus and Newborn, pp. 639–41. ( London: Academic Press )
Eden, G. J. and Hanson, M. A. (1985). The effect of hypoxia from birth on the biphasic response of the newborn rat to acute hypoxia. J. Physiol. (In press)
Carse, E. J., Wilkinson, A., Whyte, P., Henderson-Smart, D. J. and Johnson, P. (1981). Oxygen tension, heart rate, breathing and sleep state following preterm birth. Pediatr. Res., 15, 1187 A
Darnall, R. A. and Ariagno, R. L. (1982). The effect of sleep state on active thermoregulation in the premature infant. Pediatr. Res., 16, 512–14
Brady, J. P. and Ceruti, E. (1966). Chemoreceptor reflexes in the newborn infant. J. Physiol., 184, 631–45
Haddad, G. G., Epstein, R. A., Epstein, M. A. F., Leistner, H. L., Mario, P. A. and Mellins, R. B. (1979). Maturation of ventilation and ventilatory pattern in normal sleeping infants. J. Appl. Physiol., 46, 998–1002
Carse, E. A., Wilkinson, A. R., Whyte, P., Henderson-Smart, D. J. and Johnson, P. (1981). Oxygen and carbon dioxide tensions, breathing and heart rate in normal infants during the first six months of life. J. Dev. Physiol., 3, 85–100
Hoppenbrouwers, T., Harper, R. M., Hodgman, J. E., Sterman, M. B. and McGinty, D. J. (1978). Polygraphic studies of normal infants during the first six months of life. II: Respiratory rate and variability as a function of state. Pediatr. Res., 12, 120–5
Haddad, G. G., Epstein, R. A., Epstein, M. A. F., Leistner, H. L. and Mellins, R. B. (1980). The R-R interval and R-R variability in normal infants during sleep. Pediatr. Res., 14, 809–11
Harper, R. M., Hoppenbrouwers, T., Sterman, M. B., McGinty, D. J. and Hodgman, J. (1976). Polygraphic studies of normal infants during the first 6 months of life. I: Heart rate and variability as a function of state. Pediatr. Res., 10, 945–51
Hathorn, M. K. S. (1978). Analysis of periodic changes in ventilation in newborn infants. J. Physiol., 285, 85–99
Gennser, G. and Hathorn, M. K. S. (1979). Analysis of breathing movements in the human fetus. Lancet, 1, 1298
Waggener, T. B., Stark, A. R., Cohlan, B. A. and Frantz, I. D. (1984). Apnea duration is related to ventilatory oscillation characteristics in newborn infants. J. Appl. Physiol., 57, 536–44
Thach, B. T. and Taeusch, H. W. (1976). Sighing in newborn human infants: role of inflation-augmenting reflex. J. Appl. Physiol., 41, 502–7
Fleming, P. J., Goncalves, A. L., Levine, M. R. and Woollard, S. (1984). The deve-lopment of stability of respiration in human infants: changes in ventilatory responses to spontaneous sighs. J. Physiol., 347, 1–16
Johnson, P. (1976). Evidence for lower airway chemoreceptors in newborn lambs. Pediatr. Res., 10, 462
Cleave, J. P., Levine, M. R. and Fleming, P. J. (1984). The control of ventilation: a theoretical analysis of the response to transient disturbances. J. Theor. Biol., 108, 261–83
Cleave, J. P., Fleming, P. J., Levine, M. R. and Long, A. M. (1985). Stability of the control of breathing in newborn infants: a non-linear mathematical analysis. In Jones, C. J. (ed.) Physiological Development of the Fetus and Newborn, pp. 267–72. ( London: Academic Press )
Cleave, J. P., Fleming, P. J., Levine, M. R. and Long, A. M. (1985). A mathematical study of the ventilatory response to a deep sigh. J. Physiol., 364, 68 P
Cherniack, N. S., von Euler, C., Homma, I. and Kao, F. F. (1979). Experimentally induced Cheyne Stokes breathing. Resp. Physiol., 37, 185–200
Johnson, P. (1985). The development of breathing. In Jones, C. J. (ed.) The Physiological Development of the Fetus and Newborn, pp. 201–10. ( London: Academic Press )
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 MTP Press Limited
About this chapter
Cite this chapter
Fleming, P.J., Levine, M.R., Long, A.M., Cleave, J. (1987). The Maturation of the Control of Respiration in Infancy. In: Walters, D.V., Strang, L.B., Geubelle, F. (eds) Physiology of the Fetal and Neonatal Lung. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4155-7_8
Download citation
DOI: https://doi.org/10.1007/978-94-009-4155-7_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8344-7
Online ISBN: 978-94-009-4155-7
eBook Packages: Springer Book Archive