Abstract
Mechanical ventilation of the lung has two functions: to produce cyclic volume exchange and to increase the mean lung volume. The volume exchange is primarily to eliminate CO2 by manipulating tidal volume and frequency. This function is a mechanical substitute for respiratory muscles which can’t or won’t perform their accustomed task. The second function, increasing mean lung volume, is an attempt to open up closed or flooded units to decrease shunt. To accomplish this the strategy is much less clear-cut. It can be achieved by altering peak pressure and rate as in the first function, but it can also be achieved by increasing end-expiratory pressure or reversing the I:E ratio. Here the ventilator is being used as a mechanical strut one of the real problems with mechanical ventilators is that these two j functions can become inextricably tangled so that the optimum setting for O2 exchange may not be the optimum setting for CO2. The unique advantage of high-frequency ventilation is that it separates these two functions; the ‘high frequency’ uses novel fluid dynamic principles to eliminate CO2 without cyclic volume exchange while oxygenation is controlled by continuous positive pressure.
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Bryan, A.C. (1987). Mechanical Ventilation: The Role Of High-Frequency Ventilation. In: Walters, D.V., Strang, L.B., Geubelle, F. (eds) Physiology of the Fetal and Neonatal Lung. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4155-7_20
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DOI: https://doi.org/10.1007/978-94-009-4155-7_20
Publisher Name: Springer, Dordrecht
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