Abstract
There are three potential mechanisms by which the alveolar surfactant system can be altered:
-
1.
lack of surface-active material;
-
2.
changes in the relative composition of its lipid or protein compounds;
-
3.
inhibitory effect of a factor or factors leaked from the intravascular or interstitial space due to increased permeability of the capillary endothelial and/or alveolo-epithelial barrier.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Seeger, W., Wolf, H., Stahler, G., Neuhof, H. and Roka, L. (1982). Increased pulmonary vascular resistance and permeability due to arachidonate metabolism in isolated rabbit lungs. Prostaglandins, 23, 157–73
Seeger, W., Bauer, M. and Bhakdi, S. (1984). Staphylococcal alpha-toxin elicits hypertension in isolated rabbit lungs. Evidence for thromboxane formation and the role of extracellular calcium. J. Clin. Invest., 74, 849–58
Seeger, W., Wolf, H. R. D., Neuhof, H. and Roka, L. (1982). Release and oxygenation of arachidonic acid: nonspecific triggering and pathophysiological consequences in isolated rabbit lungs. In Samuelsson, B. et al. (eds.) Advances in Prostaglandin, Thromboxane and Leukotriene Research. Vol 12, pp. 99–105. ( New York: Raven Press )
Seeger, W., Radinger, H. and Neuhof, H. (1984). Increase in the capillary filtration coefficient of isolated rabbit lungs due to non-cyclooxygenase pathway of arachidonic acid (Abstract). Int. J. Microcirc. Clin. Exp., 3, 351
Seeger, W., Wolf, H. R. D., Stahler, G. and Neuhof, H. (1983). Alteration of pressure-volume characteristics due to different types of edema induction in isolated rabbit lungs. Respiration, 44, 273–81
Seeger, W., Stöhr, G., Wolf, H.R.D. and Neuhof, H. (1985). Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer. J. Appl. Physiol., 58, 326–38
Seeger, W., Wolf, H., Bauer, M., Neuhof, H. and Roka, L. (1982). Comparative influence of LTC4, LTD4 and LTE4 on the pulmonary vaculature in isolated rabbit lungs. (Abstract). V. Int. Conf. Prostaglandins, Florence, May 1982, Abstract Book, p. 350
Lutz, F., Seeger, W., Schischke, B., Weiner, R. and Schramm, W. (1983). Effects of a cytotoxic protein from pseudomonas aeruginosa on phagocytic and pinocytic cells: in vitro and in vivo studies. Toxicon Suppl., 3, 257–60
Clements, J. A., Hustead, R. F., Johnson, R. P. and Gribetz, I. (1961). Pulmonary surface tension and alveolar stability. J. Appl. Physiol., 16, 444–50
Hildebran, J. N., Goerke, J. and Clements, J. A. Pulmonary surface film stability and composition. J. Appl. Physiol., 47, 604–11
Reifenrath, R. and Zimmerman, I. (1973). Surface tension properties of lung alveolar surfactant obtained by alveolar micropuncture. Respir. Physiol., 19, 369–93
Abrams, M. E. (1966). Isolation and quantitative estimation of pulmonary surface-active protein. J. Appl. Physiol., 21, 718–20
Taylor, F. B. and Abrams, M. E. (1966). Effect of surface active lipoprotein on clotting and fibrinolysis, and of fibrinogen on surface tension of surface active lipoprotein. Am. J. Med., 40, 346–50
Balis, J. U., Shelley, S. A., McCue, M. J. and Rappaport, E. S. (1971). Mechanisms of damage to the lung surfactant system. Exp. Mol. Pathol., 14, 243–62
Ikegami, M., Jobe, A. and Glatz, T. (1981). Surface activity following natural surfactant treatment in premature lambs. J. Appl. Physiol., 51, 306–12
Jobe, A., Ikegami, M., Jacobs, H., Jones, S. and Conaway, D. (1983). Permeability of premature lambs to protein and the effect of surfactant on that permeability. J. Appl. Physiol., 55, 169–76
Ikegami, M., Jobe, A., Jacobs, H. and Lam, R. (1984). A protein from airways of premature lambs that inhibits surfactant function. J. Appl. Physiol., 57, 1134–42
Wasi, S., Burrowes, C. E., Hay, J. B. and Movat, H. Z. (1983). Plasminogen activator and plasminogen activity from sheep alveolar macrophages. Thrombos. Res., 30, 27–45
Egan, E. A., Nelson, R. M. and Beale, E. F. (1980). Lung solute permeability and lung liquid absorption in premature ventilated fetal goats. Pediatr. Res., 14, 314–18
Ambrus, C. M., Choi, T. S., Cunnanan. E., Eisenberg, B., Staub, H. P., Weintraub, S. H., Couvey, N. G., Patterson, R. J., Jockin, H., Pickren, J. W., Bross, I. D., Jung, O. S. and Ambrus, J. L. (1977). Prevention of hyaline membrane disease with plasminogen. J. Am. Med. Assoc., 237, 1837–41
Strang, L. B. (1976). The permeability of lung capillary and alveolar walls as deterxminants of liquid movements in the lung. In Porter, B. and O’Connor, M. (eds.) Ciba Foundation Symposium, Lung Liquids, pp. 49–58. ( Amsterdam and New York: Elsevier )
Hawgood, S., Benson, B. J. and Hamilton, R. L. (1985). Effects of a surfactant associated protein and calcium ions on the structure and surface activity of lung surfactant lipids. Biochemistry, 24, 184–90
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 MTP Press Limited
About this chapter
Cite this chapter
Seeger, W., Stöhr, G., Neuhof, H. (1987). Surfactant Inhibitory Plasma-Derived Proteins. In: Walters, D.V., Strang, L.B., Geubelle, F. (eds) Physiology of the Fetal and Neonatal Lung. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4155-7_16
Download citation
DOI: https://doi.org/10.1007/978-94-009-4155-7_16
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8344-7
Online ISBN: 978-94-009-4155-7
eBook Packages: Springer Book Archive