Abstract
The distinction between tonic and phasic activity occurring in the isolated colon corresponds to the localized versus propagated colonic activity recorded in the conscious dog. The myogenic activity of the circular muscular layer, unaltered by atropine and adrenergic antagonists in vitro, seems equivalent to the localized spike burst (LSB) activity enhanced by prostaglandin synthetase inhibitors in vivo. The phasic activity of the longitudinal muscular layer, coupled to that of the circular layer via myenteric cholinergic neurones, is similar to the propagated spike bursts (PSB) either isolated or in series (MSB) under the control of a permanent inhibitory sympathetic innervation.
The ubiquitous secretory effects of prostanoids and the prostaglandin-mediated motor effects of several peptides indicate a possible interspecific therapeutic value of anti-inflammatory drugs in several cases of motor or secretory disturbances of the colon.
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Ruckebusch, Y., Bardon, T., Cherbut, C., Pairet, M., Ferré, J.P. (1986). Smooth muscle pharmacology of the large intestine. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_12
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DOI: https://doi.org/10.1007/978-94-009-4153-3_12
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