Zusammenfassung
In Viet Nam stieg in den letzten Jahren die Häufigkeit des primären Leberzellkarzinoms (HCC) sprunghaft an, besonders in den Gebieten, die während den II.Indochinakrieges intensiv mit dem mit Dioxin (TCDD) verunreinigten Herbizid “Agent Orange” besprüht worden waren. Da nur bei älteren Karzinomträgern eine Korrelation mit persistierender viraler Hepatitis B nachzuweisen war und da in Viet Nam die sonst in tropischen Ländern als weitere Hauptverursacher des HCC angesehenen Faktoren wie Mykotoxine oder Schistosomiasis und Opisthorchosis fehlen, wird die Rolle des TCDD in der Genese des HCC vor allem bei jüngeren Patienten diskutiert. TCDD könnte entweder direkt auf Grund seiner Hepatotoxizität oder indirekt als “promoting Agent” wirken, das im Rahmen der Zweiphasentheorie nur die morphologische Manifestation einer vorangehenden malignen Transformation induziert.
In commemoration of Professor Ton That Tung, famous surgeon and scientist, previous chief of the Viet Duc Hospital, Hanoi (S.R. of Viet Nam) who raised and maintained the discussion on the long-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Party supported by Grant TSD-M-044-NL of the Commission of the European Communities
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alpert, H.E., Hutt, M.S.R. and Davidson, C.S. (1968). Hepatoma in Uganda: A study in geographis pathology. Lancet i, 1265–1267
Greig, J.B., Jones, G., Butler, W.H. and Barnes, J.M. (1973). Toxic effects of 2,3,7, 8-tetrach1orodibenzo-p-dioxin. Food and Cosmetic Toxicology 11, 585–595
Hay, A. (1980). Chemical company suppresses dioxin report. Nature 284, 2
Jerusalem, C. and Kubat, K. (1983). Considerations anatomo-pathologiques du carcinome hepatoce1luiaire chez les vietnamiens exposes aux phenoxy-herbicides militaires contamines par la TCDD. In: Symposium International sur les herbicides et defoliants employes dans la guerre. Comite National d’Investigation, pp. 53–62, Hanoi
Kociba, R.J., Keyes, D.G., Beyer, J.E., Carreon, R.M. and Gehring, P.J. (1979). Long-term toxicologic studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in laboratory animals. Ann. N.Y. Acad. Sci. 320, 397–404
McConnel, E.E. and Moore, J.A. (1979). Toxicopathology of the halogenated aromatic’s. Ann. N.Y. Acad.Sci. 320, 138–150
Pazderova-Vejlupkova, A.J., Lukas, E., Nemcova, M., Pickova, J. and Jirasek, L. (1981). The development and prognosis of chronic intoxication by tetra-chlorodibenzo-p-dioxin in men. Arch.Environ.Health 36, 5
Pitot, H.C. and Sirica, A.E. (1980). The stages of initiation and promotion in hepatocarcinogenesis. Biochim.Biophys. Acta 605, 191–215
Pitot, H.C., Goldsworthy, T., Campbell, H.A. and Poland, A. (1980). Quantitative evaluation of the pro motion by 2, 3,7,8-etrachlrodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamin. Cancer Res. 40, 3616–3620
Shikata, L., Uzawa, T., Joshiwara, N., Akatsuka, T. and Yamazaki, S. (1974). Staining methods of Australia antigen in paraffin sections. Detection of cytoplasmi inclusion bodies. Japan. J. Exp. Med. 44, 25–36
Sugar, J., Toth, K., Csuka, O., Gati, E. and Somfai-Relle, S. (1979). Role of pesticides in hepato-carcinogenesis. J.Toxicol.Environ.Health. 5, 183–191
Sun, M. (1983). Dioxins uncertain legacy. Science 219, 468–469
Westing, A.H. (1984). Herbicides in war. The long-term ecological and human consequences. Taylor and Francis London and Philadelphia.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 MTP Press Limited
About this chapter
Cite this chapter
Jerusalem, C., Kubat, K., Eling, W. (1986). Hepatitis B versus Dioxin (TCDD) in the Pathogenesis of Excess Primary Liver Cell Carcinoma in Viet Nam. In: Brölsch, C.E., Zelder, O. (eds) Experimental and Clinical Hepatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4151-9_7
Download citation
DOI: https://doi.org/10.1007/978-94-009-4151-9_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8342-3
Online ISBN: 978-94-009-4151-9
eBook Packages: Springer Book Archive