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The Role of Kupffer Cells, Endothelial Cells, and Hepatocytes in Uridine Catabolism of Rat Liver

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Book cover Experimental and Clinical Hepatology

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Zusammenfassung

Die Funktion von Kupfferzellen (KC), Endothelzellen (EC) und Hepatozyten (HC) beim Uridinkatabolismus der Rattenleber wurde anhand der verschiedenen mittels Zentrifugalelutriation getrennten Leberzellpopulationen untersucht. Die Ergebnisse zeigen eine rasche und effektive Phosphorolyse von Uridin zu Uracil durch KC, während EC und HC in dieser Hinsicht wesentlich weniger aktiv sind. Dagegen ließ sich ein vollständiger Abbau des Uridin zu CO2, ß-Alanin und Ammoniak nur für HC nachweisen. Diese Befunde sind vereinbar mit einer Kooperation von Leberzellen, wobei vornehmlich KC Blutplasmauridin in Uracil überführen, das dann erst durch HC vollständig abgebaut werden kann.

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References

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Author information

Authors and Affiliations

  1. Medizinische Universitätsklinik Greiburg, Hugstetter Str. 55, Freiburg, Germany

    Dr. med. H.-G. Leser, A. Holstege, J. Pausch & W. Gerok

Authors
  1. Dr. med. H.-G. Leser
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  2. A. Holstege
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  3. J. Pausch
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  4. W. Gerok
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Editor information

Editors and Affiliations

  1. Department of Surgery Section of Hepatobiliary Surgery and Liver Transplantation, The University of Chicago, USA

    Christof E. Brölsch

  2. Zentrum für Operative Medizin I Klinik für Allgemeinchirurgie, Philipps-Universität Marburg, West Germany

    Oskar Zelder

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© 1986 MTP Press Limited

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Leser, HG., Holstege, A., Pausch, J., Gerok, W. (1986). The Role of Kupffer Cells, Endothelial Cells, and Hepatocytes in Uridine Catabolism of Rat Liver. In: Brölsch, C.E., Zelder, O. (eds) Experimental and Clinical Hepatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4151-9_29

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  • DOI: https://doi.org/10.1007/978-94-009-4151-9_29

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8342-3

  • Online ISBN: 978-94-009-4151-9

  • eBook Packages: Springer Book Archive

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