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The Effect of Portacaval Shunt on the 14CO2-Exhalation from (Methyl-14C)-Labelled Drugs

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Experimental and Clinical Hepatology

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Zusammenfassung

Die Abatmung von 14CO2 aus (methyl-14C)-markierten Arzneimittein wurde bei männlichen Wistar-Ratten 21 Tage nach portocavaler End-zu-Seit-Anastomose (PCA) gemessen. Einer Verminderung des Gehalts der Leber an Cytochrom P-450 um 70% entsprach eine Abnahme der 14CO2 -Exhalation (CER) aus (Methyl-14C)-Aminopyrin und -Antipyrin sowie eine Verlängerung der Abatmungshalbwertzeit (CHL). Dagegen war die Abatmungsrate von 14C02 nach Sättigungsdosen von Methacetin (500 μmol/kg) nur um 30% vermindert und die CHL nach 20 μmol/kg war von 30 auf 42 min verlängert. Hepatektomie nach PCA führte zu einer Senkung der CER auf 10% des Kontrollwertes, so daß eine ennenswerte extrahepatische Dernethy1ierung von Methacetin ausgeschlossen ist.

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Author information

Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Philipps-Universität Marburg, D-3550, Marburg/Lahn, Lahnberge, Germany

    Dr. Christian Steffen

Authors
  1. Dr. Christian Steffen
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  2. O. Zelder
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Editor information

Editors and Affiliations

  1. Department of Surgery Section of Hepatobiliary Surgery and Liver Transplantation, The University of Chicago, USA

    Christof E. Brölsch

  2. Zentrum für Operative Medizin I Klinik für Allgemeinchirurgie, Philipps-Universität Marburg, West Germany

    Oskar Zelder

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© 1986 MTP Press Limited

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Steffen, C., Zelder, O. (1986). The Effect of Portacaval Shunt on the 14CO2-Exhalation from (Methyl-14C)-Labelled Drugs. In: Brölsch, C.E., Zelder, O. (eds) Experimental and Clinical Hepatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4151-9_17

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  • DOI: https://doi.org/10.1007/978-94-009-4151-9_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8342-3

  • Online ISBN: 978-94-009-4151-9

  • eBook Packages: Springer Book Archive

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