Zusammenfassung
Glyceroltrinitrat (GTN) führt zur Erschlaffung der glatten Muskulatur von Blutgefäßen. Es wurde daher für möglich gehalten, daß es den Pfortaderhochdruck bei Patienten mit Leberzirrhose vermindern könnte. Mit der kürzlich beschriebenen endoskopischen Feinnadelpunktion von Ösophagusvarizen konnte der Einfluß von GTN auf den intravasalen Ösophagusvarizendruck (IOVD) gemessen werden. Drei Minuten nach sublingualer Gabe von 2.2 mg GTN fiel der IOVD bei 10 Patienten mit Varizen Grad III von 22.8 ± 2.0 mmHg auf 12.0 ± 0.4 mmHg (p◄0.005) und bei sechs Patienten mit Varizen Grad II von 16.3 ± 0.4 mmHg auf 10.0 ± 0.4 mmHg (p◄0.005). Unsere bisherigen Ergebnisse lassen vermuten, daß GTN zur Blutstillung bei der Ösophagusvarizenblutung geeignet sein könnte. Weitere Studien sollten darüber Aufschluß geben, ob Langzeitnitrate auch zur Prophylaxe der Varizenblutung geeignet sind.
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Staritz, M., Poralla, T., Hütteroth, T., Meyer zum Büschenfelde, K.H. (1986). The Effect of Glyceryl Trinitrate on the Intravascular Oesophageal Variceal Pressure in Patients with Cirrhosis and Portal Hypertension. In: Brölsch, C.E., Zelder, O. (eds) Experimental and Clinical Hepatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4151-9_14
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DOI: https://doi.org/10.1007/978-94-009-4151-9_14
Publisher Name: Springer, Dordrecht
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