Abstract
The association of multiple sclerosis (MS) with HLA-A3, B7 and DR2 is well established in most northern European populations suggesting the existence of an MS susceptibility locus closely linked to HLA. The demonstration of a negative association has been more problematic due to compensatory decreases in frequencies of antigens other than DR2 and antigens in linkage disequilibrium. Attempts have also been made to correlate HLA antigens and clinical characteristics including type of disease course and rate of progression (Madigand et al. 1982, Meyer-Rienecker et al. 1982).
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References
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© 1986 ECSC, EEC, EAEC, Brussels and Luxembourg
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Carton, H. et al. (1986). HLA-Antigens in Multiple Sclerosis Patients in the Benelux. In: Hommes, O.R. (eds) Multiple Sclerosis Research in Europe. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4143-4_44
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DOI: https://doi.org/10.1007/978-94-009-4143-4_44
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8338-6
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