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A Multicenter Study of the Incidence of Multiple Sclerosis in Italy. Design of the Study

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Multiple Sclerosis Research in Europe

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Abstract

Although the etiology of multiple sclerosis (MS) is still obscure, epidemiological studies have shown a geographical distribution correlated to latitude, with three zones of high, medium and low frequency (Kurtzke, 1980). Italy, extending from 37° to 46° North latitude, lies just below the borderline between the first two zones.

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References

  • Alperovich, A. and Bouvier, M.H., 1982. Geographical pattern of death rates from multiple sclerosis in France. An analysis of 4912 death. Acta Neurol. Scand., 66: 454–461.

    Article  Google Scholar 

  • Alter, M., Lebovitz, V. and Speer, J., 1966. Risk of multiple sclerosis related to age at immigration to Isreal. Arch. Neurol., 15: 234–237.

    PubMed  CAS  Google Scholar 

  • Amaducci, L., Arfaioli, C., Inzitari, D. and Marchi, M., 1982. Multiple sclerosis among shoe and leather workers: an epidemiological survey in Florence. Acta Neurol. Scand., 65: 94–103.

    Article  PubMed  CAS  Google Scholar 

  • Beebe, G.W., Kurtzke, J.F., Kurland, L.T., Auth, L.T. and Nagler, B., 1967. Studies on the natural history of multiple sclerosis: 3. Epidemiologic analysis of the army experience in world war II. Neurology (Minneap.), 17: 1–17.

    PubMed  CAS  Google Scholar 

  • Borri, P., Tavolato, B.F., Ballatori, F. and Cazzullo, C.L., 1976. Epidemiological survey on multiple sclerosis in Italy. Riv. Pat. Nerv. Ment. 97: 205–210.

    PubMed  CAS  Google Scholar 

  • Bramanti, P., Messina, C., Scuderi, D. and Vita, G., 1978. An epidemiological study on multiple sclerosis in the province of Messina, Italy. Acta Neurol., 34: 133–141.

    Google Scholar 

  • Dean, G. and Kurtzke, J.F., 1971. On the risk of multiple sclerosis according to age at inmigrati on to South-Africa. Br. Med. J., 3: 725–729.

    Article  PubMed  CAS  Google Scholar 

  • Dean, G., Grimaldi, G., Kelly, R. and Karhausen, L., 1979. Multiple sclerosis in south Europe. I: prevalence in Sicily in 1975. J. Epidemiol. Commun. Health, 33: 107–110.

    Article  CAS  Google Scholar 

  • Dean, G., Savettieri, G., Taibi, G., Monreale, S. and Karhausen, L., 1981. The prevalence of multiple sclerosis in Sicily. II: Agrigento City. J. Epidemiol. Commun. Health, 35: 118–122.

    Google Scholar 

  • Granieri, E. and Rosati, G., 1982. Italy: a medium or high-risk area for multiple sclerosis? An epidemiologic study in Barbagia, Sardinia, Southern Italy. Neurology, 32: 466–472.

    PubMed  CAS  Google Scholar 

  • Hyllested, K., 1961. Lethality, duration and mortality of disseminated sclerosis in Denmark. Acta Psych. Scand., 35: 553–564.

    Google Scholar 

  • Kurland, L.T., Stazio, A. and Reed, D., 1965. An appraisal of population studies of multiple sclerosis. Ann. N.Y. Acad. Sci., 122: 520–544.

    Google Scholar 

  • Kurtzke, J.F., Kurland, L.T. and Golberg, I.D., 1971. Mortality and migration in multiple sclerosis. Neurology, 21: 1186–1197,

    PubMed  CAS  Google Scholar 

  • Kurtzke, J.F., Beebe, G.W. and Norman, J.E., 1979a. Epidemiology of multiple sclerosis in U.S. veterans: I. Race, sex and geographic distribution. Neurology, 29: 1228–1235.

    Google Scholar 

  • Kurtzke, J.F. and Hyllested, K., 1979b. Multiple sclerosis in the Faroe Island: I. Clinical and epidemiological features. Ann. Neurol., 5: 6–21.

    Article  CAS  Google Scholar 

  • Kurtzke, J.F., 1980. Epidemiologic contribution to multiple sclerosis: an overview. Neurology, 30: 61–79.

    PubMed  CAS  Google Scholar 

  • Kurtzke, J.F., Gudmundsson, K.R. and Bergmann, S., 1982. Multiple sclerosis in Iceland: 1. Evidence of a postwar epidemic. Neurology, 32: 143–150.

    Google Scholar 

  • Macchi, G., Sanginaro, M. and Valla, S., 1962. La sclerose en plaques dans la province de Parma, Italy. World Neurol., 3: 731–739.

    Google Scholar 

  • Mamoli, A., Fera, L., Camerlingo, M. and Alfieri, R., 1980. Sclerosi multipla: indagine epidemiologica nella provincia di Bergamo (dati preliminari). 2nd Italian Meeting of Neuroepidemiology, Milan ( Italy ), December 12–13.

    Google Scholar 

  • Marforio, S., Caputo, D., Zibetti, A., Ghezzi, A., Di Costanzo, M. and Palestra, A., 1980. Sclerosi multipla: ricerca epidemiologica in provincia di Varese. Arch. Sci. Med. ( Torino ), 137: 1–8.

    Google Scholar 

  • Me Alpine, D., Lumsden, C.E. and Acheson, E.D., 1972. Multiple sclerosis: a reappraisal. Churchill Livingstone, Edinburg.

    Google Scholar 

  • Megna, G., 1980. Rilievi epidemiologici sulla sclerosi multipla nella provincia di Bari. 2nd Italian Meeting of Neuroepidemiology, Milan ( Italy ), December 12–13.

    Google Scholar 

  • Millar, J.H.D., 1971. Multiple sclerosis: a disease acquired in childhood. Springfield, Illinois.

    Google Scholar 

  • Nardi, P.G., 1979. Studio epidemiologico sulla sclerosi multipla nella provincia di Venezia. Riv. Pat. Nerv. Ment., 100: 121–142.

    Google Scholar 

  • Paci, A., Ottaviano, P. and Freddi, A., 1980. La sclerosi multipla nella regione umbra: dati epidemiologici relativi alla provincia di-Terni. 2nd Italian Meeting of Neuroepidemiology, Milan ( Italy ), December 12–13.

    Google Scholar 

  • Palma, V., Ciambellini, M. and Buscaino, G.A., 1981. Indagine epidemiologica, sulla sclerosi multipla nelle province di Napoli e Avellino. Acta Neurol., 42: 280–290.

    CAS  Google Scholar 

  • Reggio, A., Pero, G. and Campo, G., 1979. Indagine geo-demografica sulla sclerosi multipla nella provincia di Catania: risultati di un primo censimento. Boll. Soc. Med. Chir. Catania, 46: 151–155.

    Google Scholar 

  • Rosati, G., Pinna, L. and Granieri, E., 1977. The distribution of multiple sclerosis in Sardinia. Riv. Pat. Nerv. Ment., 98: 46–64.

    Google Scholar 

  • Rosati, G., Granieri, E., Carreras, M. and Tola, R., 1980a. Multiple sclerosis in southern Europe: a prevalence study in the socio-sanitary district of Copparo, Northern Italy. Acta Neurol. Scand., 62: 244–249.

    Article  CAS  Google Scholar 

  • Rosati, G., Granieri, E., Carreras, M., Pinna, L., Tola, R. and Paolino, E., 1980b. Epidemiologia della sclerosi multipla in piccole communità dell’Italia settentrionale ed insulare. 2nd Italian Meeting of Neuro-epidemiology, Milan ( Italy ), December 12–13.

    Google Scholar 

  • Rosati, G., Granieri, E. and Carreras, M., 1981. Multiple sclerosis in Northern Italy: prevalence in the province of Ferrara in 1978. Ital. J. Neurol. Sci., 2: 17–23.

    Google Scholar 

  • Rose, A.S., Ellison, G.W., Myers, L.W. and Tourtellotte, W.W., 1976. Criteria for the clinical diagnosis of multiple sclerosis. Neurology, 26 (6: part 2), 20–27.

    PubMed  CAS  Google Scholar 

  • Rossi, G., Ferrari, G. and Dalri, E., 1980. Sclerosi multipla nella provincia di Trento: ricerca epidemiologica. 2nd Italian Meeting of Neuroepidemiology, Milan ( Italy ), December 12–13.

    Google Scholar 

  • Savettieri, G., Piccoli, F. and Chiaravalle, E., 1978. Epidemiological survey on multiple sclerosis in the city of Palermo, Italy. Acta Neurol., 33: 526–531.

    CAS  Google Scholar 

  • Savettieri, G., Karhausen, L. and Dean, G., 1981. The prevalence of multiple sclerosis in Sicily. I: Monreale city. J. Epidemiol. Commun. Health, 35: 114–117.

    Google Scholar 

  • Savettieri, G., Grimaldi, G., Giordano, D., Ventura, A. and Karhausen, L. La sclerosis multipla in Sicilia: altri dati epidemiologici (personal communication).

    Google Scholar 

  • Tavolato, B.F., 1971. Multiple sclerosis in Padova province, Italy. Acta Neurol. Scand., 50: 76–90.

    Article  Google Scholar 

  • Wikström, J. and Palo, J., 1975. Studies on the clustering of multiple sclerosis in Finland. I. Comparison between the domiciles and place of birth in selected subpopulations. Acta Neurol. Scand., 51: 85–98.

    Article  PubMed  Google Scholar 

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Authors
  1. G. Comi
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Editors and Affiliations

  1. Department of Neurology, Radboud University Hospital, Reinier Postlaan 4, 6525 GC, Nijmegen, The Netherlands

    Otto R. Hommes

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© 1986 ECSC, EEC, EAEC, Brussels and Luxembourg

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Comi, G. (1986). A Multicenter Study of the Incidence of Multiple Sclerosis in Italy. Design of the Study. In: Hommes, O.R. (eds) Multiple Sclerosis Research in Europe. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4143-4_42

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  • DOI: https://doi.org/10.1007/978-94-009-4143-4_42

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8338-6

  • Online ISBN: 978-94-009-4143-4

  • eBook Packages: Springer Book Archive

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