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Immunological Aspects

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The Future of Predictive Safety Evaluation

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Abstract

In order to survive and resist invasion by parasitic and pathogenic micro-organisms, multicellular life forms evolved a variety of specific and non-specific defence mechanisms. The present-day vertebrate immune system therefore represents the end-result of a series of gradual adaptive cellular and chemical responses designed to ensure the survival of a species in the face of a changing and potentially hostile environment. Our understanding of immunity and the immune system as a whole has, over the past few decades, matured rapidly from the early recognition of non-specific or natural resistance to infectious agents - mediated for example by complement and lysozymal enzymes. This evolved to an appreciation of distinct specific cell-mediated and humoral responses, and more recently the identification and functional characterization of various subpopulations of lymphoid cells [1]. Analysis of immune responses in man and experimental animals has revealed the immune system to be a finely tuned and precisely controlled mechanism involving multiple integrated reactions between subsets of thymus-matured lymphocytes (T cells), bone marrow/bursa-matured lymphocytes (B cells) and a variety of antigen-processing and accessory cells of macrophage origin.

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Authors
  1. K. Miller
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  2. S. Nicklin
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Editor information

Editors and Affiliations

  1. Cantab Group, Cambridge, England

    A. N. Worden

  2. Department of Biochemistry, University of Surrey, Guildford, England

    D. V. Parke

  3. Girton College, Cambridge, England

    J. Marks (Director of Medical Studies) (Director of Medical Studies)

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© 1986 MTP Press Limited

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Miller, K., Nicklin, S. (1986). Immunological Aspects. In: Worden, A.N., Parke, D.V., Marks, J. (eds) The Future of Predictive Safety Evaluation. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4139-7_14

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  • DOI: https://doi.org/10.1007/978-94-009-4139-7_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8336-2

  • Online ISBN: 978-94-009-4139-7

  • eBook Packages: Springer Book Archive

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