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Abstract

Pesticides provide important benefits in agriculture and public health [1,2] and the balance of evidence shows that these chemicals are not producing an epidemic of poisoning[1,3–6]. However, some aspects of present hazard evaluation procedures can be criticized.

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References

  1. Buchel, KH (1984). Political economic and philosophical aspects of pesticide use for human welfare. Regul Toxicol Pharmacol, 4, 174–91

    Article  Google Scholar 

  2. Mrak, EM (1984). Pesticides: the good and the bad. Regul Toxicol Pharmacol, 4, 28–36

    Article  PubMed  CAS  Google Scholar 

  3. Goulding, R (1983). Poisoning on the farm. J Soc Occup Med, 33, 60–5

    Article  Google Scholar 

  4. Bonsall, JL (1985). Pesticides and health in developed countries. In Turnbull, GJ (ed.) Occupational Hazards of Pesticide Use. pp. 51–66. ( Basingstoke: Taylor and Francis )

    Google Scholar 

  5. Copplestone, JF (1985). Pesticide exposure and health in developing countries. In Turnbull, GJ (ed.) Occupational Hazards of Pesticide Use. pp. 51–66. ( Basingstoke: Taylor and Francis )

    Google Scholar 

  6. Goulding, R (1985). Pesticide safety. In Turnbull, GJ (ed.) Occupational Hazards of Pesticide Use. pp. 1–12. ( Basingstoke: Taylor and Francis )

    Google Scholar 

  7. Corbett, JR, Wright, K and Baillie, AC (1984). The Biochemical Mode of Action of Pesticides. ( London: Academic Press )

    Google Scholar 

  8. Hearn, CED (1973). A review of agricultural pesticide incidents in man in England and Wales, 1952-71. Br J Indust Med, 30, 253–8

    Google Scholar 

  9. Hayes, WJ (1982). Pesticides Studied in Man. ( Baltimore: Williams and Wilkins )

    Google Scholar 

  10. Turnbull, GJ (1984). Pesticide residues in food - a toxicological view. J Roy Soc Med, 77, 932–5

    Google Scholar 

  11. Thomas, B (1983). Pesticide Registration in the United Kingdom and Europe. Pesticide Residues, Ministry of Agriculture Fisheries and Food pp. 211–218. Ref. book 347. ( London: HMSO )

    Google Scholar 

  12. Turnbull, GJ, Sanderson, DM and Crome, SJ (1985). Exposure to pesticides during application. In Turnbull, GJ (ed.) Occupational Hazards of Pesticide Use. pp. 35–49. ( Basingstoke: Taylor and Francis )

    Google Scholar 

  13. EPA (1984). Proposed guidelines for carcinogen risk assessment. Fed Reg, 49, 46294–301

    Google Scholar 

  14. Turnbull, GJ (1985). Current trends and future needs. In Turnbull, GJ (ed.) Occupational Hazards of Pesticide Use. pp. 99–116. ( Basingstoke: Taylor and Francis )

    Google Scholar 

  15. Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (1981). Guidelines for the Testing of Chemicals for Mutagenicity. DHSS Report on Health and Social Subjects No. 24. ( London: HMSO )

    Google Scholar 

  16. EPA (1982). Pesticides Assessment Guidelines, Sub division F Hazard Evaluation Human and Domestic Animals. ( Springfield: National Technical Information Service )

    Google Scholar 

  17. Interdisciplinary Panel on Carcinogenity (1984). Criteria for evidence of chemical carcinogenicity. Science, 225, 682–7

    Google Scholar 

  18. Jennings, JD (1985). Chemical Carcinogens; A Review of the Science and its Associated Principles, Part II: State of the Science. Office of Science and Technology Policy. Fed Reg, 10371–442 14 March

    Google Scholar 

  19. Ashby, J (1984). A logical approach to the detection of carcinogens and mutagens. In Critical Evaluation of Mutagenicity Tests. BGA Schriften 3/84, pp. 497–507. ( Munich: MMV Medizin Verlag)

    Google Scholar 

  20. Garner, RC (1984). Comparison of results between whole animal studies and short-term tests for mutagenicity or carcinogenicity. In Critical Evaluation of Mutagenicity Tests. BGA Schriften 3/84, pp. 509–524. ( Munich: MMV Medizin Verlag)

    Google Scholar 

  21. Shelby, MD and Stasiewicz, S (1984). Chemicals showing no evidence of carcinogenicity in long-term, two-species rodent studies: the need for short-term test data. Environ Mutagen, 6, 871–8

    Article  Google Scholar 

  22. Thomas, B (1984). Pesticides and soils: a regulatory review. In Hance, RJ (ed.) Soils and Crop Protection Chemicals, pp. 15–23. British Crop Protection Council Monograph No. 27

    Google Scholar 

  23. Nicolson, RS (1984). Association of Public Analysts surveys of pesticide residues in Food, 1983. J Assoc Publ Analysts, 22, 51–7

    Google Scholar 

  24. MAFF (1982). Report of the Working Party on Pesticide Residues (1977– 1981 ). Ministry of Agriculture Fisheries and Food. (London: HMSO )

    Google Scholar 

  25. GIFAP (1984). Pesticide Residues in Food. ( Brussels: Groupment International des Associations Nationales De Fabricants De Pesticides)

    Google Scholar 

  26. Jeyaratnam, J (1985). Health problems of pesticide usage in the Third World. Br J Indust Med, 42, 505–6

    Google Scholar 

  27. EPA (1984). Proposed guidelines for mutagenicity risk assessment. Fed Reg, 49, 46314–21

    Google Scholar 

  28. FAO/WHO (1984). Pesticide Residues in Food-Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues, Held in Geneva, 5 to 14 December 1983. FAO Plant Production and Protection Paper No. 56. ( Rome: FAO )

    Google Scholar 

  29. OECD (1981). Guidelines for Testing of Chemicals. (Paris: OECD)

    Google Scholar 

  30. EPA (1978). Proposed Guidelines for Registering Pesticides, Subpart F. Fed Reg, 43, 37336–403

    Google Scholar 

  31. Goldstein, BD (1985). Risk assessment and risk management. Environ Toxicol Chem, 4, 1–2

    Article  CAS  Google Scholar 

  32. Stitch, HF (ed.) (1982). Carcinogens and Mutagens in the Environment-Vol. I: Food Products. ( Florida: CRC Press )

    Google Scholar 

  33. Maugh, TH (1978). Chemical carcinogens: how dangerous are low doses. Science, 202, 37–41

    Article  PubMed  Google Scholar 

  34. Clegg, DJ (1979). Animal reproduction and carcinogenicity studies in relation to human safety evaluation. Toxicol Occup Med, 4, 45–59

    Google Scholar 

  35. Guess, H, Crump, K and Peto, R (1977). Uncertainty estimates for low-dose rate extrapolations of animal carcinogenicity data. Cancer Res, 37, 3475–83

    PubMed  CAS  Google Scholar 

  36. Krewski, D, Clayson, DB, Collins, B and Munro, IC (1982). Toxicological procedures for assessing the carcinogenic potential of agricultural chemicals. In Fleck, RA and Hollaender, A (eds) Genetic Toxicology, Basic Life Science Vol. 21. ( New York: Plenum Press )

    Google Scholar 

  37. California Health and Welfare Agency (1982). Carcinogen Identification Policy: A Statement of Science as a Basis of Policy, Section 2: Methods for Estimating Cancer Risks from Exposure to Carcinogens. (Sacramento: Health and Welfare Agency )

    Google Scholar 

  38. Crump, KS, Guess, HA and Deal, KL (1977). Confidence intervals and test of hypotheses concerning dose response relations inferred from animal carcinogenicity data. Biometrics, 33, 437–51

    Google Scholar 

  39. Carlborg, FW (1979). Cancer, mathematical models and aflatoxin. Food Cosmet Toxicol, 17, 159–66

    Article  Google Scholar 

  40. Anon (1981). Re-examination of the ED 01 Study Review of Statistics: The need for realistic statistical models for risk assessment. Fund Appl Toxicol, 1, 123–6

    Article  Google Scholar 

  41. Purchase, IFH (1985). Formaldehyde: how serious is the risk to pathologists. Bull Roy Coll Pathol, 50, 4–8

    Google Scholar 

  42. Squire, RA (1981). Ranking animal carcinogens: a proposed regulatory approach. Science, 214, 877–80

    Article  Google Scholar 

  43. Pitot, HC (1980). Relationship of bioassay data on chemicals to their toxic and carcinogenic risk for humans. In Demopoulos, HB and Mehlman, MA (eds), Cancer and the Environment, pp. 431–50. ( Washington: Pathotox )

    Google Scholar 

  44. Munro, IC and Krewski,DR (1981). Risk assessment and regulatory decision making. Food Cosmet, Toxicol, 19, 549–60

    Google Scholar 

  45. Ramsey, JC,Park, CN,Ott, MG and Gehring, PJ (1979). Carcinogenic risk assessment: ethylene dibromide. Toxicol Appl Pharmacol, 47, 411–14

    Article  Google Scholar 

  46. Clayson, WB,Krewski,D and Munro, I (1985). Toxicological Risk Assessment, Vol. II: General Criteria and Case Studies (Florida: CRC Press )

    Google Scholar 

  47. ECETOC (1982). Hepatocarcino gene sis in Laboratory Rodents Relevance for Man. (Brussels: European Chemical Industry Ecology and Toxicology Centre, Monograph No. 4 )

    Google Scholar 

  48. ECETOC (1982). RiskAssessmentof OccupationalChemical Carcinogens. (Brussels: European Chemical Industry Ecology and Toxicity Centre, Monograph No. 3 )

    Google Scholar 

  49. Haseman, JK (1985). Issues in carcinogenicity testing: dose selection. Fund Appl Toxicol, 5, 66–78

    Article  CAS  Google Scholar 

  50. Morton, DB andGriffiths, PHM (1985). Guidelines on the recognition of pain,distress and discomfort in experimental animals and an hypothesis for assessment. Vet Rec, 116, 431–6

    Article  Google Scholar 

  51. Ames,BN(1983). Dietary carcinogens and anticarcinogens - oxygen radicals and degenerative diseases. Science, 221, 1256–63

    Article  Google Scholar 

  52. Grasso, P (1983). Carcinogens in food. In Conning, DM and Lansdown, ABG (eds) Toxic Hazards inFood. pp. 122–44. ( London: Croom Helm )

    Google Scholar 

  53. Shank, RC (ed.) (1981). Mycotoxins and N-Nitroso Compounds: Environmental Risks, Vol. I. ( Florida: CRC Press )

    Google Scholar 

  54. Forbes, P (1985). The natural way to chemical warfare. New Sci, 1461, 27

    Google Scholar 

  55. Einhellig, FA (1985). Allelopathy - a natural protection, allochemicals. In Mandave, N (ed.) Handbook of Natural Pesticides: Methods. Vol. I, pp. 161–200. ( Florida: CRC Press )

    Google Scholar 

  56. Stich, HF (ed)(1983). Carcinogensand Mutagensinthe Environment, Vol. Ill: Naturally OccurringCompounds: Epidemiology and Distribution. (Florida: CRC Press)

    Google Scholar 

  57. National Research Council (1982). Diet, Nutrition and Cancer. ( Washington: National Academy Press )

    Google Scholar 

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Turnbull, G.J. (1986). Evaluating the Hazards of Pesticides. In: Worden, A.N., Parke, D.V., Marks, J. (eds) The Future of Predictive Safety Evaluation. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4139-7_10

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  • DOI: https://doi.org/10.1007/978-94-009-4139-7_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8336-2

  • Online ISBN: 978-94-009-4139-7

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