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Water Soluble Cyclodextrin Polymers: Their Interaction with Drugs

  • Conference paper
Inclusion Phenomena in Inorganic, Organic, and Organometallic Hosts

Part of the book series: Advances in Inclusion Science ((AIS,volume 4))

  • 150 Accesses

Abstract

The complex forming ability of a water-soluble ß-cyclodextrin epichlorohydrin polymer (CDPS) and its different molecular weight fractions was studied and compared with the complexing properties of ß-cyclodextrin (ßCD) and dimethyl-ßCD (DM-ßCD). CDPS was separated into two main fractions. CDPS and its fractions formed well soluble inclusion compounds with the studied drugs. The low molecular weight fraction formed rather stable complexes with small guest molecules, the high molecular weight fraction was found to be more efficient in binding larger substrates. Structural studies of furosemide-CD complexes were attempted by NMR spectroscopy.

Presented at the Fourth International Symposium on Inclusion Phenomena and the Third International Symposium on Cyclodextrins, Lancaster, U.K., 20–25 July 1986.

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Author information

Authors and Affiliations

  1. Chinoin Pharmaceutical and Chemical Works Ltd., Budapest, Endrődi S- u. 38/40, Hungary, H-1026

    J. Szemán, E. Fenyvesi & J. Szejtli

  2. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142, Japan

    H. Ueda, Y. Machida & T. Nagai

Authors
  1. J. Szemán
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  2. E. Fenyvesi
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  3. J. Szejtli
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  4. H. Ueda
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  5. Y. Machida
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  6. T. Nagai
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Editor information

Editors and Affiliations

  1. Department of Chemistry, University of Alabama, USA

    Jerry L. Atwood

  2. Department of Chemistry, University of Lancaster, UK

    J. Eric D. Davies

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© 1987 D. Reidel Publishing Company

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Szemán, J., Fenyvesi, E., Szejtli, J., Ueda, H., Machida, Y., Nagai, T. (1987). Water Soluble Cyclodextrin Polymers: Their Interaction with Drugs. In: Atwood, J.L., Davies, J.E.D. (eds) Inclusion Phenomena in Inorganic, Organic, and Organometallic Hosts. Advances in Inclusion Science, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3987-5_55

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  • DOI: https://doi.org/10.1007/978-94-009-3987-5_55

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8269-3

  • Online ISBN: 978-94-009-3987-5

  • eBook Packages: Springer Book Archive

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