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Inclusion Phenomena in Inorganic, Organic, and Organometallic Hosts pp 39–43Cite as

Increasing the Solubility of Drugs Through Cyclodextrin Complexation

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Part of the book series: Advances in Inclusion Science ((AIS,volume 4))

Abstract

The bioavailability of pharmaca which dissolve in water only with difficulty is very limited. The cyclodextrins /CDs/, and primarily β-CD and γ-CD, were successfully applied to increase the dissolution characteristics and hence the bioavailability of drugs: furosemide, hydrochlorothiazide, mebendazole, metronidazole, spironolactone, tofisopam, vinpocetine base, etc. From these pharmaca, products were made by mixing, kneading, grinding, freeze-drying, spray-embedding and precipitation.

The more important factors on which the dissolution and bioavailability of the drugs depend are concluded.

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References

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Author information

Authors and Affiliations

  1. Department of Pharmaceutical Technology, University Medical School, P. O. Box 121, H-6701, Szeged, Hungary

    M. Kata & B. Selmeczi

Authors
  1. M. Kata
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  2. B. Selmeczi
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Editor information

Editors and Affiliations

  1. Department of Chemistry, University of Alabama, USA

    Jerry L. Atwood

  2. Department of Chemistry, University of Lancaster, UK

    J. Eric D. Davies

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© 1987 D. Reidel Publishing Company

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Kata, M., Selmeczi, B. (1987). Increasing the Solubility of Drugs Through Cyclodextrin Complexation. In: Atwood, J.L., Davies, J.E.D. (eds) Inclusion Phenomena in Inorganic, Organic, and Organometallic Hosts. Advances in Inclusion Science, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3987-5_2

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  • DOI: https://doi.org/10.1007/978-94-009-3987-5_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8269-3

  • Online ISBN: 978-94-009-3987-5

  • eBook Packages: Springer Book Archive

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