Abstract
The interrelationship of octanol/water partition coefficients (Kow), bioconcentration factors (KB) and toxicity was used, in combination with first-order, one-compartment model assumptions, to estimate toxicant kinetic parameters. This was accomplished via non-linear curve fitting to time-toxicity data from typical LC50 toxicity tests. Preliminary results for a limited data set are presented. It appears that:
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1.
The differences between the internal toxicant concentration endpoints for toxicity and bioconcentration are proportional to the bioconcentration factor.
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2.
This proportional relationship can be used to convert kinetics data from a bioconcentration basis to a toxicity basis and vice versa.
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3.
Quantitative structure-kinetics relationships (QSKRs) can be constructed using one-compartment, first-order kinetics constants and a molecular descriptor.
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References
Brooke, L.T., Call, D.J., Geiger, D.L. and Northcott, C.E. (Eds.) 1984. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas). University of Wisconsin-Superior, Superior, Wisconsin.
Call, D.J., Brooke, L.T., Knuth, M., Poirier, S. and Hoglund, M. 1985. Fish subchronic toxicity prediction model for industrial organic chemicals that produce narcosis. Environ. Toxicol. Chem. 4: 335–341.
Chew, R. and Hamilton, M. 1985. Toxicity curve estimation: fitting a compartment model to median survival times. Trans. Am. Fish. Soc. 114: 403–412.
Ferguson, J. 1939. The use of chemical potentials as indices of toxicity. Proc. R. Soc. London, Ser. B. 127: 387–404.
Ferguson, J. and Piri, H. 1948. The toxicity of vapours to the grain weevil. Ann. Appi. Biol. 35: 532–550.
Halfon, E. 1985. Regression method in ecotoxicology: a better formulation using the geometric mean functional regression. Environ. Sci. Technol. 19: 747–749.
Hawker, D. and Connell, D. 1985. Relationships between partition coefficient, uptake rate constant, clearance rate constant, and time to equilibrium for bioconcentration. Chemosphere 14: 1205–1219.
Mackay, D. 1982. Correlation of bioconcentration factors. Environ. Sci. Technol. 16: 274.
Mancini, J. 1983. A method for calculating the effects, on aquatic organisms, of time varying concentrations. Water Res. 17:1335–1362.
McCarty, L.S. 1987. Relationship between toxicity and bioconcentration for some organic chemicals. I. Examination of the relationship. In QSAR in Environmental Toxicology - II, Kaiser, K.L.E. (Ed.), D. Reidel Publ. Co., Dordrecht, Holland, pp. 207–220.
McGowan, J. 1951. The physical toxicity of chemicals I. Vapours. J. Appl. Chem. 1:120–126.
McGowan, J. 1952a. The physical toxicity of chemicals II. Factors affecting physical toxicity in aqueous solutions. J. Appl. Chem. 2: 323–328.
McGowan, J. 1952b. The physical toxicity of chemicals III. A systematic treatment of physical toxicity in aqueous solutions. J. Appl. Chem. 2: 651–658.
McKim, J., Schmieden P. and Veith, G.D. 1985. Absorption dynamics of organic chemical transport across trout gills as related to octanol-water partition coefficient. Tox. Appl. Pharmacol. 7:1–10.
Sokal, R. and Rohlf, G. 1981. Biometry. Second Edition. W.H. Freeman and Company, San Francisco.
Spacie, A. and Hamelink, J. 1982. Alternative models for describing the bioconcentration of organisms in fish. Environ. Toxicol. Chem. 1: 309–320.
Sprague, J. 1970. Review Paper: Measurement of pollutant toxicity to fish - II. Utilizing and applying bioassay results. Water Res. 4: 3–32.
Veith, G.O., Call, D.J. and Brooke, L.T. 1983. Structure-toxicity relationship for the fathead minnow (Pimephales prometas): Narcotic industrial chemimcals. Can. J. Fish. Aquat. Sci. 40: 743–748.
Walbridge, C., Fiandt, J.T., Phipps, G.L. and Holcombe, G.W. 1983. Acute toxicity of ten chlorinated aliphatic hydrocarbons to the fathead minnow (Pimephales promelas). Arch. Environ. Contam. Toxicol. 12: 661–666.
Zitko, V. 1979. An equation of lethality curves in tests with aquatic fauna. Chemosphere 2:47–51.
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McCarty, L.S. (1987). Relationship Between Toxicity and Bioconcentration for Some Organic Chemicals. II. Application of the Relationship. In: Kaiser, K.L.E. (eds) QSAR in Environmental Toxicology - II. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3937-0_17
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DOI: https://doi.org/10.1007/978-94-009-3937-0_17
Publisher Name: Springer, Dordrecht
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