Abstract
Although human gamma interferon (IFNγ) is a well-defined lymphokine of central importance for the immune system, the cellular origin of its production still remains to be determined. This question has until now been studied either by enriching or depleting IFNγ-producing cells in unfractionated cell cultures, as well as by scrutinizing IFNγ synthesizing cell lines and hybridomas. These approaches have, however resulted in incomplete information.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Laskay T, Andersson U, Andersson J, Kiessling R, DeLey M: An immune-fluorescent method for identifying individual IFN -producing lymphocytes. J Immunol Meth eds. (in press).
Reinherz EL, Meuer S, Fitzgerald KA, Hussey RE, Levine H, Schlossman SF: Antigen recognition by human T lymphocyytes is linked to surface expression of the T3 molecular complex. Cell 30: 735, 1982.
Uchiyama T, Broder S, Waldmann TA: A monoclonal antibody (anti-TAC) reactive with activated and functionally mature human T cells. J Immunol 126: 1393, 1981.
Perussia B, Starr S, Abraham S, Fanning V, Trinchieri G: Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc-receptor functions. J. Immunol 130: 2133, 1983.
Chang TW, McKinney S, Liu V, Kung PC, Vilcek J, Le J: Use of monoclonal antibodies as sensitive and specific probes for biologically active human gamma-interferon. Proc Natl Acad Sci USA 81: 5219, 1984.
Troje-Blomberg M, Andersson G, Stoczkowska M, Shabo R, Romero P, Patarrayo E, Wigzell H, Perlmann P: Production of IL2 and IFN-gamma by T cells from malaria patients in response to Plasmodium falciparum or erythrocyte antigens in vitro. J Immunol 135: 3498, 1985.
Berthold W, Zahn G: Antiviral Res ABSTR 1:69 (meeting abstract).
Stefanos S, Wietzezkin J, Catinot L, Devos R, Jalcoff R: Characterization of antibodies against recombinant Hu IFN-gamma produced by hybridoma cells. J Interferon Res 5: 455, 1985.
Virtanen I, Ekblom P, Lauria P: Subcellular compartmentalization of saccharide moieties in cultured normal and malignant cells. J Cell Biol 85: 429, 1980.
Wakasugi N, Virelizier JL: Defective IFNγ production — the human neonate. J Immunol 134: 67, 1985.
von Wussow P, Platsoucos CD, Wiranowska-Stewart M, Stewart WE: Human γ-interferon production by leukocytes induced with monoclonal antibodies recognizing T cells. J Immunol 127: 1197, 1981.
Farrar WL, Johnson HM, Farrar JJ: Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2. J Immunol 126: 1120, 1981.
Rinnoy-Kan EA, Wright SD, Welte K, Wang CY: Fc receptors on Monocytes cause OKT3-treated lymphocytes to internalize T3 and secrete IL2. Cell Immunol 98: 181, 1986.
Chang T-W, Testa D, Kung PC, Perry L, Dreskin HJ, Goldstein G: Cellular origin and interactions involved in γ -interferon production induced by OKT3 monoclonal antibody. J. Immunol. 128: 585, 1982.
O’Malley JA, Nussbaum-Blumenson A, Sheedy D, Grossmeyer BJ, Ozer H: Identification of the T cell subset that produces human γ -interferon. J Immunol 128: 2522, 1982.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Andersson, U., Laskay, T., Andersson, J., Kiessling, R., DeLey, M. (1987). Phenotype of γ-Interferon Producing Leukocytes. In: Cantell, K., Schellekens, H. (eds) The Biology of the Interferon System 1986. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3543-3_36
Download citation
DOI: https://doi.org/10.1007/978-94-009-3543-3_36
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8084-2
Online ISBN: 978-94-009-3543-3
eBook Packages: Springer Book Archive