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Differential Structures and Activities of Three IFN α2 Variants Departing Only at Two Amino Acid Positions

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Book cover The Biology of the Interferon System 1986

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Abstract

Almost 40 human interferon (IFN) a sequences have been derived from various c-DNA and chromosomal libraries (1). Cataloguing DNA segments containing IFN sequences, made it possible to distinguish 18 IFN α related loci in the chromosome (1,2,3). A genetic study based on 25 families, has restricted the number of different IFN α loci to about 17 (4) and has revealed a high degree of polymorphism in the human IFN a loci. For many of the known IFN α sequences it is not possible to decide whether they represent alleles or different loci, when they are compared to each other.

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Author information

Authors and Affiliations

  1. Dept of Bacteriology, Karolinska Institute, S-104 01, Stockholm, Sweden

    A. v. Gabain

  2. Inst. of Appl. Cell and Molec. Biology, University of Umeå, S-901 87, Umeå, Sweden

    A. v. Gabain, M. Ohlsson & E. Lundgren

  3. KabiGen AB, S-112 87, Stockholm, Sweden

    E. Holmgren & S. Josephsson

  4. Ciba Geigy Ltd., CH-4002, Basle, Switzerland

    S. S. Alkan

Authors
  1. A. v. Gabain
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  2. M. Ohlsson
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  3. E. Holmgren
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  4. S. Josephsson
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  5. S. S. Alkan
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  6. E. Lundgren
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Editor information

Editors and Affiliations

  1. National Public Health Institute, Helsinki, Finland

    K. Cantell

  2. Primate Center, TNO, Rijswijk, The Netherlands

    H. Schellekens

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© 1987 Martinus Nijhoff Publishers, Dordrecht

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v. Gabain, A., Ohlsson, M., Holmgren, E., Josephsson, S., Alkan, S.S., Lundgren, E. (1987). Differential Structures and Activities of Three IFN α2 Variants Departing Only at Two Amino Acid Positions. In: Cantell, K., Schellekens, H. (eds) The Biology of the Interferon System 1986. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3543-3_2

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  • DOI: https://doi.org/10.1007/978-94-009-3543-3_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8084-2

  • Online ISBN: 978-94-009-3543-3

  • eBook Packages: Springer Book Archive

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