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Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 14))

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Abstract

Just now, we are having the semicentenary of the discovery of the element 43, later on named “technetium” (1,2). In 1937, Perrier and Segré showed that radioactive isotopes of element 43 could be formed by neutron or deuteron bombardment of molybdenum. They investigated the activity in order to collect some information on the chemistry of 43. By the introduction of technetium-99m into nuclear medicine in the early sixties the chemistry of technetium, especially its coordination chemistry, has been promoted into new spotlight.

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References

  1. Perrier C, Segré E, Radioactive isotopes of element 43. Nature 1937; 140: 193.

    Article  CAS  Google Scholar 

  2. Perrier C, Segré E, Technetium: the element of atomic number 43. Nature 1947; 159: 24.

    Article  CAS  Google Scholar 

  3. Johannsen B, Advances in radiochemistry of Tc-99m. in: Cox PH, Mather SJ, Sampson CB, Lazarus CR (eds), Progress in radiopharmacy, 1986. Martinus Nijhoff Publishers 1986; 135 - 154.

    Google Scholar 

  4. Wagner Jr HN, SPECT and PET advances herald new era in human biochemistry; The Society of Nuclear Medicine scientific meeting highlights. J Nucl Med 1986; 27: 1227.

    Google Scholar 

  5. 2nd Intern, symposium on technetium in chemistry and nuclear medicine. Padova, Italy, Sept 9 - 11, 1985.

    Google Scholar 

  6. 6th Intern, symposium on radiopharmaceutical chemistry. Boston, June 29-July 3, 1986.

    Google Scholar 

  7. Volkert WA, Troutner DE Hoffman TJ, Seger RM, Holmes RA, Tc-99m-propyleneamine oxime Tc-99m-PnA0): A potential brain radiopharmaceutical. J Nucl Med 1983; 24: 128.

    Google Scholar 

  8. Volkert WA, Hoffman TJ, Seger RM, Troutner DE, Holmes RA, Tc-99m-propy1eneamine oxime Tc-99m-PnA0): A potential brain radiopharmaceutical. Eur J Nucl Med 1984; 9: 511.

    Article  PubMed  CAS  Google Scholar 

  9. Neirinckx RD, Nowotnik DP, Pickett RD, Harrison RC, Ell PJ, Development of a lipophilic Tc-99m-complex useful for brain perfusion evaluation with conventional SPECT imaging equipment, in: Proc. workshop of the Rheinisch-Westf. Ges. f.Nuklearmedizin, Oct 12-13, 1984. Walter de Gruyter, Bonn 1984.

    Google Scholar 

  10. Nowotnik DP, Canning IR, Cumming SA, Harrison RC, Higley B, Nechvatal G, Pickett RD, Piper IM, Bayne V J, Forster AM, Weisner PS, Neirincks RD, Volkert WA, Troutner DE, Holmes RA, Development of a Tc-99m-1abel1ed radiopharmaceutical for cerebral blood flow imaging. Nucl Med Commun 1985; 6: 499.

    Article  PubMed  CAS  Google Scholar 

  11. Chaplin SB, Oberle PA, McKenzie EH, Hoffman TJ, Volkert WA, Holmes RA, Canning LR, Pickett RD, Nowotnik DP, Neirinckx RD, Regional cerebral uptake and retention of Tc-99m-tetramethy1 - and pentamethyl-propylene amine oxime chelates. Nucl Med Biol 1986; 13: 261.

    CAS  Google Scholar 

  12. Sharp PF, Smith FW, Gemmell HG, Lyall D, Evans NTS, Gvozdanovic D, Davison J, Tyrrell DA, Pickett RD, Neirinckx RD, technetium-99m HM PAO stereoisomers as potential agents for imaging regional blood flow: Human volunteer studies. J Nucl Med 1986; 27: 171.

    PubMed  CAS  Google Scholar 

  13. Gruner KR, Die Entwicklung heutiger Radiopharmaka aus der Sicht des Herstellers. Der Nuklearmediziner 1986; 9: 297.

    CAS  Google Scholar 

  14. Ell PJ, Hocknel1 JML, Jarritt PH, Cullum I, Lui D, Campos-Costra D, Nowotnik DP, Pickett RD, Canning LR, Neirinckx RD, A Tc-labelled radiotracer for the investigation of cerebral vascular disease. Nucl Med Commun 1985; 6: 437.

    Article  PubMed  CAS  Google Scholar 

  15. Ell PJ, Costa DC, Kinetics of Tc compound favor its use in SPECT. Diagnostic Imaging, June 1986: 112 - 117.

    Google Scholar 

  16. Neirinckx RD, Clinical experience with CeretecTM, the first widely available Tc-99m agent for rCBF measurement. RAD, April 1986; 18 - 20.

    Google Scholar 

  17. Reichmann K, Biersack HJ, Basso L, Hartmann A, Matthews ITW, Neirinckx RD, Pickett RD, Winkler C, A comparative study of brain uptake and early kinetics of Tc-99m-dl HM-PAO and other PnAO derivatives in baboons. Nucl Med 1986; 25: 134.

    CAS  Google Scholar 

  18. Podreka I, Suess E, Goldenberg G, Steiner M, Brücke Th, Müller Ch, Deecke L, Initial experience with Tc-99m-hexa- methyl-propyleneamine oxime (Tc-99m-HMPA0) brain SPECT, (abstract) J Nucl Med 1986; 27: 887.

    Google Scholar 

  19. deRoo M, Berbruggen A, van Pamel G, Mortelmans L, deSaede- ler J, Dom R, Malfroid M, Lammens M, Mul ti detector SPECT gray matter imaging with Tc-99m-HM-PA0 in dementia, (abstract) Nucl Med 1986; 25: A 34.

    Google Scholar 

  20. Peters AM, et al., Clinical experience with Tc-99m-hexame- thyl-propylene-amineoxime for labelling leucocytes and imaging inflammation, in press.

    Google Scholar 

  21. Schümichen C, el al., Tc-99m HM-PAO labelling of leucocytes for detection of imflammatory bowel disease, in press.

    Google Scholar 

  22. Epps LA, Burns HD, Lever SZ, Goldfarb HW, Kervitsky TM, Wong DJ, Kramer AV, Wagner Jr HN, The chemistry and biology of technetium(V) oxo complexes of N-piperidiny1e- thyl diaminodithiolate for brain imaging, in: Nicolini M, Bandoli G, Mazzi U (eds.), Technetium in chemistry and nuclear medicine. 2. Raven press, New York, 1986: 171.

    Google Scholar 

  23. Lever SZ, Burns HD, Kervitsky TM, Goldfarb HW, Woo DV, Wong DF, Design, preparation, and biodistribution of a technetium-99m tri aminedithiol complex to assess regional cerebral blood flow. J Nucl Med 1985; 26: 1287.

    PubMed  CAS  Google Scholar 

  24. Goldfarb HW, Scheffel U, Lever SZ, Burns HD, Wagner Jr HN, Comparison of Tc-99m aminoethyl diami nodithiol analogues for blood flow imaging, (abstract). J Nucl Med 1986; 27: 1050.

    Google Scholar 

  25. Bok BD, Scheffel U, Goldfarb HW, Burns HD, Lever SZ, Wong DF, Wagner Jr HN, Comparative pharmacokinetics of Tc-99m- aminoethyl-diami nodithiol (DADT) derivatives and 1-123- iodoamphetamine for regional brain blood flow imaging, (abstract). Nucl Med 1986; 25: A 77.

    Google Scholar 

  26. Baidoo KE, Lever SZ, Kramer AV, Epps, LA, Burns HD, Wagner Jr HN, Synthesis of Tc-99m-N2S2 complexes via the p-metho- xybenzy1 protected thiol ligand, (abstracht). J Nucl Med 1986; 27: 1050.

    Google Scholar 

  27. Lever SZ, Baidoo KE, Kramer AV, Burns HD, Epps LA, Scheffel U, Wagner Jr HN, Synthesis and evaluation of new technetium-99m complexes. 3. Eur Symp Radiopharmacy and Radiopharmaceuticals. Elsimore 1987.

    Google Scholar 

  28. Neves M, Libson K, Deutsch E, Technetium-99m radiopharmaceuticals for brain perfusion imaging, in: Nicolini M, Bandoli G, Mazzi U (eds.), Technetium in chemistry and nuclear medicine. 2. Raven press, New York, 1986; 122.

    Google Scholar 

  29. Deutsch E, Libson K, Vanderheyden JL, Technetium-99m myocardial imaging agents. Personal communication.

    Google Scholar 

  30. Münze R, Syhre R, Seifert S, Klötzer S, Mohnike W, Schmidt H, Myocardial imaging agents labelled with technetium-99m. Proc. Conf. Radiopharm. and Labelled Compounds 1984, Tokyo. IAEA Vienna 1985; 249.

    Google Scholar 

  31. Münze R, Kretzschmar M, Syhre R, Kampf G, Klötzer D, Güthert I, Bergmann R, Biokinetic data of various radioactive cationic molecules. An attempt at evaluation of significant chemical properties of myotropic agents, in: Nicol ini M, Bandoli G, Mazzi U (eds.), Technetium in chemistry and nuclear medicine. 2. Raven press, New York, 1986; 197.

    Google Scholar 

  32. Gerundini P, Deutsch E, Savi A, Tyrrel DA, Fazio F, Evaluation of new Tc-99m-radiopharmaceutica1s for heart and brain studies, in: Nicolini M, Bandoli G, Mazzi U (eds.), Technetium in chemistry and nuclear medicine. 2. Raven press, New York, 1986; 333.

    Google Scholar 

  33. Dean RT, Wester DW, Nosco DL, Adams MD, Coveney JR, Robbins MS, McElvany KD, De Jong R, Progress in the design, evaluation and development of Tc-99m radiopharmaceuticals. in: Nicolini M, Bandoli G, Mazzi U (eds.), Technetium in chemistry and nuclear medicine. 2. Raven press, New York, 1986; 147.

    Google Scholar 

  34. Seifert S, Schneider F, Syhre R, Muenze R, The development of a new myocardial imaging agent based on DMPE. Annual report, Centrel Instute of Nuclear Research, Rossendorf, G.D.R, 1986.

    Google Scholar 

  35. Deutsch E, Vanderheyden JL, Gerundini P, Libson K, Hirth W, Savi A, Zecca L, Fazio F, Development of nonreducible 99m-technetium(111) cations as myocardial perfusion imaging agents, (abstract). J Nucl Med 1986; 27: 894.

    Google Scholar 

  36. Münze R, Mohnike W, Syhre R, Schmidt J, Seifert S, Successful imaging of the human heart by using an improved technetium phosphine radiopharmaceuticai, (abstract). Nucl Med 1986; 25: A 46.

    Google Scholar 

  37. Syhre R, Seifert S, Schneider F, Münze R, Mohnike W, Schmidt J, Gisske H, Bach H, Ein Tc-99m-Radiopharmakon auf DMPE-Basis - geeignet zur planaren Szintigraphie und zu SPECT-Untersuchungen des Herzens. NucCompact 1986; 17: 199.

    CAS  Google Scholar 

  38. Jurisson SS, Dancey K, McPartlin M, Tasker PA, Deutsch E, Synthesis, charaterization, and electrochemical properties of technetium complexes containing both tetradentate Schiff base and monodentate tertiary phosphine ligands: Single-crystal structure of trans- (N,N’ -ethylene bis (acetyl acetone iminato)) bis (tri phenylphosphine) technetium (III) hexafluorophosphate. Inorg Chem 1984; 23: 4743.

    Article  CAS  Google Scholar 

  39. Nunn AD, Treher EN, Feld T, Boronic acid adducts of technetium ox ime imaging capabilities, (abstract). J Nucl Med 1986; 27: 893.

    Google Scholar 

  40. Narra RK, Feld T, Wedeking P, Matyas J, Nunn AD, SQ 30,217, a technetium 99m labelled myocardial imaging aqent which shows no interspecies differences in uptake, (abstract). J Nucl Med 1986; 27: 1051.

    Google Scholar 

  41. Thompson M, X-ray photoelectron spectroscopy of potential technetium-based organ imaging agents. Anal Chem 1986; 58: 3100.

    Article  CAS  Google Scholar 

  42. Unger SE, McCormick TJ, Treher EN, Nunn AD, A comparison of desorption ionization methods for the analysis of neutral seven-coordinate technetium radi opharmaceuti cais. Anal Chem (In press).

    Google Scholar 

  43. Nunn AD, personal communication.

    Google Scholar 

  44. Williams SJ. Mousa SA, Morgan RA, Caroll TR, Maheu LJ, Pharmacology of Tc-99m-isonitriles: Agents with favorable characteristics for heart imaging, (abstract) 1986; 27: 877.

    Google Scholar 

  45. Mousa SA, Williams SJ, Myocardial uptake and retention of Tc-99m-hexakisaliphatic isonotriles: Evidence for speci-ficity, (abstract). J Nucl Med 1986; 27: 995.

    Google Scholar 

  46. Williams SJ, Mousa SA, Mahent J, Carroll TR, Morgan RA, Identification of a Tc-99m hexakis-isoni tri 1 e with favorable pharmacokinetics for myocardial perfusion scinti-graphy, (abstract). Nucl Med 1986; 25: A 45.

    Google Scholar 

  47. McKusick K, Holman BL, Jones AG, Davison A, Rigo P, Sporn V, Vosberg H, Moretti J, Comparison of 3 Tc-99m isoni- triles for detection ischemic heart disease in humans, (abstract). J Nucl Med 1986; 27: 878.

    Google Scholar 

  48. Holman BL, Sporn V, Jones AG, Sia STB, Perez-Balino N, Davison A, Lister-James J, Kronauge JF, Mitta AEA, Camin LL, Campbell S, Williams SJ, Carpenter AT, Myocardial imaging with technetium-99m CPI: initial experience in the human. J Nucl Med 1987; 28: 13.

    PubMed  CAS  Google Scholar 

  49. Fritzberg AR, Kasina S, Eshima D, Johnson DL, Synthesis and biological evaluation of technetium-99m MAG3, as a hippuran replacement. J Nucl Med 1986; 27: 111.

    PubMed  CAS  Google Scholar 

  50. Taylor Jr A, Eshima D, Fritzberg AR, Christian PE, Kasina S, Comparison of iodine-131 OIH and technetium-99m MAG3 renal imaging in volunteers. J Nucl Med 1986; 27: 795.

    PubMed  Google Scholar 

  51. Taylor Jr A, Eshima D, Christian PE, Fritzberg AR, Kasina S, Comparison of Tc-99m mercaptoacety1 triglycerine (MAG3) and OIH in normal subjects and patients, (abstract). J Nucl Med 1986; 27: 1986.

    Google Scholar 

  52. Fritzberg AR, Rao TN, Adhikesavalu D, Camerman A, Vander- heyden JL, Synthesis and characterization of Re And Tc complexes of N2S2 and N3S ligands. 6th Intern. Symp. Radiopharm. Chem. Boston 1986, paper 45 (abstract).

    Google Scholar 

  53. Nosco DL, Manning RG, Fritzberg A, Characterization of the new Tc-99m dynamic renal imaging agent: Tc-99m MAG.,, (abstract). J Nucl Med 1986; 27: 939. J

    Google Scholar 

  54. Taylor Jr A, personal communication

    Google Scholar 

  55. Verbruggen A, Dekempeneer P, Cleynhens B, Hoogmartens M, De Roo M, Synthesis and renal excretion characteristics of isomeric methyl derivatives of Tc-99m-mercaptoacetyl triglycerine. 6th Intern. Symp. Radiopharm. Chem. Boston 1986, paper 45 (abstract).

    Google Scholar 

  56. Yokoyama A, Recent progress in the development of bifunc- tional radiopharmaceuticals. Proc. Conf. Radiopharm. and labelled Compounds 1984, Tokyo. IAEA Vienna 1985; 251 - 265.

    Google Scholar 

  57. Arano Y, Magata Y, Furukawa T, Horiuchi K, Yokoyama A, Endo K, Torizuka K, Bifunctional chelating agents for Tc-99m-label1 ed monoclonal antibodies. Proc. Conf. Radio- pharm. and Labelled Compounds 1984, Tokyo. IAEA Vienna 1985; 143 - 151.

    Google Scholar 

  58. Yokoyama A, Hosotani T, Arano Y, Horiuchi K, Technetium DTS-bifunctional radiopharmaceuticais: Role of amino containing side chain on biodi stributi on. 6th Intern. Symp. Radiopharm. Chem Boston 1986, paper 47 (abstract).

    Google Scholar 

  59. Childs RL, Hnatowich DJ, Optimum conditions for labelling of DTPA-coupled antibodies with technetium-99m. J Nucl Med 1985; 26: 293.

    PubMed  CAS  Google Scholar 

  60. Childs RL, Hnatowich DJ, Optimum conditions for labelling of DTPA-coupled antibodies with technetium-99m. J Nucl Med 1985; 26: 293.

    PubMed  CAS  Google Scholar 

  61. Zollinger K, Huber G, Iftimia M, Bläuenstein P, Beer HF, Schubiger PA, Protein labelling with technetium-99m using different reducing agents and coupled bridging ligands, (abstract) Nucl Med 1986; 25: A 76.

    Google Scholar 

  62. Hosotani T, Yokoyama A, Arano Y, Horiuchi K, Saj i H, Torizuka K, Search for Tc-99m labelled DTS bifunctional radiopharmaceuticai: Role of functional groups in myocardial accumulation. Int J Appi Radiat Isot 1986; 37: 505.

    Article  CAS  Google Scholar 

  63. Arano Y, Yokoyama A, Magata Y, Horiuchi K, Saji H, Torizuka K, In the procurement of stable Tc-99m-1abel1 ed protein using bifunctional chelating agent Int J Appi Radiat Isot 1986; 37: 587.

    CAS  Google Scholar 

  64. Hosotani T, Yokoyama A, Arano Y, Horiuchi K, Wasaki H, Saji H, Torizuka K, In the procurement of a neutral and compact monomeric complex of dithiosemicarbazone (DTS) derivative: Tc-99m-KTS. Int J Nucl Med Biol 1986; 12: 431.

    Article  PubMed  CAS  Google Scholar 

  65. Arano Y, Yokoyama A, Magata Y, Saji H, Horiuchi K, Torizuka K, Synthesis and evaluation of a new bifunctional chelating agent for Tc-99m labelling proteins: p-Carbo- xyethyl phenyl glyoxal-di (N-methylthiosemicarbazone). Int J Med Biol 1986; 12: 425.

    Article  CAS  Google Scholar 

  66. Baldas J, Bonnyman J, Substitution reactions of Tc-99mNCL, - A route to a new class of Tc-99m-radiopharmaceuticals. Int J Appi Radiat Isot 1985; 36: 133.

    Article  CAS  Google Scholar 

  67. Baldas J, Bonnyman J, Effect of the Tc-nitrido group on the behaviour of Tc-99m-radiopharmaceuticais. Int J Appi Radiat Isot 1985; 36: 919.

    Article  CAS  Google Scholar 

  68. Baldas J, Bonnyman J, Williams GA, Studies of technetium complexes. 9. Use of the tetrachloronitri do technetate(VI) anion for the preparation of nitrido complexes of technetium. Crystal structure of bis. (8-quinoiinethiolato) ni tridotechnetium(V). Inorg Chem 1986; 25: 150.

    Article  CAS  Google Scholar 

  69. Abram U, Spies H, Münze R, Kaden L, Lorenz B, Wahren M, Nitrido complexes of technetium, in: Nicol ini M, Bandoli G, Mazzi U (eds.), Technetium in chemistry and nuclear medicine. 2. Raven press, New York, 1986: 81.

    Google Scholar 

  70. Abram U, Spies H, Görner W, Kirmse R, Stach J, Lipophilic technetium complexes. III. Chelate complexes of techneti um(V) containing the Tc-nitrido core. Inorg Chim Acta 1985; 109: L 9.

    Article  Google Scholar 

  71. Schumichen C, Weiss H, Tumor localization and biodistribution of Tc-99m muramylpolypeptide (MPP) in the rat. Nucl Med 1986; 25: 28.

    CAS  Google Scholar 

  72. Jeghers 0, Puttemans N, Urbain D, Ham HR, Letter to the editor: Technetium-99m DMSA uptake by metastatic carcinoma of the prostata. J Nucl Med 1986; 27: 1223.

    Google Scholar 

  73. Clarke SEM, Fogelman I, Lazarus CR, Edwards S, Maisey MN, A Comparison of 1-131 MIBG and Tc-99m-pentavalent-DMSA for imaging patients with medullary cell carcinoma of the thyroid, (abstract). Nucl Med 1986; 25:A 22.

    Google Scholar 

  74. Stadalnik RC, Truaeau WL, Vera DR, Pauly MP, TcNGA functional imaging of the liver: A model for testing the clinical role of receptor-binding radiotracers, (abstract). J Nucl Med 1986; 27: 67.

    Google Scholar 

  75. Galli G, Valle G, Maini CL, Orlando P, Giordano, Tc-99masialo-alpha-l-acid-glycoprotein: A receptor-specific radiopharmaceutical for liver scintigraphy Nucl Med 1986; 25: A55.

    Google Scholar 

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Johannsen, B. (1987). Newer Technetium-99m Radiopharmaceuticals. In: Kristensen, K., Nørbygaard, E. (eds) Safety and Efficacy of Radiopharmaceuticals 1987. Developments in Nuclear Medicine, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3375-0_3

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  • DOI: https://doi.org/10.1007/978-94-009-3375-0_3

  • Publisher Name: Springer, Dordrecht

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