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Detection of Nephrotoxicity of Foreign Chemicals with the Use of In Vitro and In Vivo Techniques

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Nephrotoxicity in the experimental and clinical situation

Part of the book series: Developments in Nephrology ((DINE,volume 19-20))

Abstract

The kidney is of paramount importance in the excretion of many potentially toxic drugs and chemicals. Investigations into the possible renal toxicity of such agents helps identify those substances that may be hazardous to health, and also provides information about normal renal function. This chapter will examine the methods used to evaluate chemical-induced nephrotoxicity, in normal experimental animals (and in some cases where some degree of renal failure has been experimentally produced); study the properties and mechanisms involved in organic anion and organic cation transport; and compare the sensitivity of various function tests in assessing nephrotoxicity.

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  1. S. Kacew
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  1. The Robens Institute, University of Surrey, Guildford, Surrey, GU2 5XH, England

    P. H. Bach

  2. Biochemical Toxicology Section, Imperial Chemical Industries plc, Alderley Park, Macclesfield, Cheshire, SKI0 4TJ, England

    E. A. Lock

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© 1987 Martinus Nijhoff Publishers

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Kacew, S. (1987). Detection of Nephrotoxicity of Foreign Chemicals with the Use of In Vitro and In Vivo Techniques. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity in the experimental and clinical situation. Developments in Nephrology, vol 19-20. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3371-2_3

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  • DOI: https://doi.org/10.1007/978-94-009-3371-2_3

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