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Xenobiotic Metabolism in the Mammalian Kidney

  • Chapter
Nephrotoxicity in the experimental and clinical situation

Part of the book series: Developments in Nephrology ((DINE,volume 19-20))

Abstract

The kidneys have a clearly defined role as excretory organs for xenobiotics and their polar metabolites. Less well understood is the involvement of the kidneys in the metabolism of xenobiotics, a function usually ascribed to the liver. The primary function of xenobiotic metabolism is to convert non-polar compounds to polar products that will not be reabsorbed from urine or bile. Although xenobiotic metabolism has been considered as a detoxification process, in certain instances, the products of metabolism may be potent toxicants. Recent investigations have shown significant catalytic activities of enzymes involved in xenobiotic metabolism in the kidney. Intrarenal xenobiotic metabolism may be a prerequisite for nephrotoxicity induced by some chemicals. Since an understanding of xenobiotic metabolizing enzymes is important in evaluating the biochemical mechanisms of nephrotoxicity, this chapter will focus on identification, localization, and activity of several renal enzymes involved in xenobiotic metabolism.

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Authors
  1. J. B. Tarloff
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  2. R. S. Goldstein
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  3. J. B. Hook
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Editors and Affiliations

  1. The Robens Institute, University of Surrey, Guildford, Surrey, England

    P. H. Bach

  2. Biochemical Toxicology Section, Imperial Chemical Industries plc, Alderley Park, Macclesfield, Cheshire, England

    E. A. Lock

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© 1987 Martinus Nijhoff Publishers

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Tarloff, J.B., Goldstein, R.S., Hook, J.B. (1987). Xenobiotic Metabolism in the Mammalian Kidney. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity in the experimental and clinical situation. Developments in Nephrology, vol 19-20. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3367-5_12

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  • DOI: https://doi.org/10.1007/978-94-009-3367-5_12

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