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Hepatic arterial infusion chemotherapy: rationale, results, credits and debits

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Progress in Surgery of the Liver, Pancreas and Biliary System

Part of the book series: Developments in Surgery ((DISU,volume 9))

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Abstract

The chemotherapy of primary and secondary neoplasms of the liver has evoked over the past decades passing through phases of single agent systemic treatment, regional infusion chemotherapy, combination chemotherapy and finally continuous regional drug delivering. This latter development has been made possible through the development of a very sophisticated biomedical device: the totally implantable pump. Since it’s introduction for continuous hepatic arterial chemotherapy in 1980 it is estimated that over 5000 implantations have been performed of the Infusaid® pump, suggesting a therapeutic fad in the treatment of liver metastases. Although the Infusaid pump represents a substantial technological advance, it is important to distinguish the device itself, it’s reliability and the role it plays in regional chemotherapy, from the efficacy of the regional approach to metastatic colorectal cancer in the liver. This chapter will mainly focus on this latter complex problem in which the pump is merely a device for the delivery of agents which, like the method itself, will be subject to a critical review of credits and debits.

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Author information

Authors and Affiliations

  1. Department of Surgery, University Hospital, PO Box 9600, 2300 RC, Leiden, The Netherlands

    C. J. H. van de Velde & L. M. de Brauw

  2. The Winship Cancer Center, Emory University School of Medicine, Atlanta, Georgia, USA

    P. H. Sugarbaker

  3. Department of Surgery, University of Lund, S-221 85, Lund, Sweden

    Karl-Göran Tranberg

Authors
  1. C. J. H. van de Velde
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  2. L. M. de Brauw
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  3. P. H. Sugarbaker
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  4. Karl-Göran Tranberg
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Editor information

Editors and Affiliations

  1. Department of Surgery, University of Lund, Lund, Sweden

    S. Bengmark

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© 1988 Martinus Nijhoff Publishers, Dordrecht

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van de Velde, C.J.H., de Brauw, L.M., Sugarbaker, P.H., Tranberg, KG. (1988). Hepatic arterial infusion chemotherapy: rationale, results, credits and debits. In: Bengmark, S. (eds) Progress in Surgery of the Liver, Pancreas and Biliary System. Developments in Surgery, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3349-1_9

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  • DOI: https://doi.org/10.1007/978-94-009-3349-1_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8004-0

  • Online ISBN: 978-94-009-3349-1

  • eBook Packages: Springer Book Archive

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