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Parasympathetic effects on electrophysiological properties of mammalian ventricular tissues

  • John C. Bailey
  • Eric N. Prystowsky
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 71)

Abstract

The heart is regulated by both limbs of the autonomic nervous system. In the sinoatrial node, the parasympathetic nervous system predominates over the sympathetic nervous system in control of heart rate (Jose and Taylor, 1969; Levy and Zieske, 1969; Prystowsky et al. 1981). In animals and human AV nodal function is under balanced influence of the parasympathetic and sympathetic nervous systems (Levy and Zieske, 1969; Prystowsky et al. 1981). The importance of resting parasympathetic tone on human ventricular refractoriness has only recently been postulated (see Reviews by Higgins, et al. 1973; Zipes et al. 1981; Rardon and Bailey, 1983).

Keywords

Action Potential Duration Parasympathetic Nervous System Purkinje Fiber Cholinergic Nerve Beta Adrenergic Blockade 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Jose AD, Taylor RR. 1969. Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man. J Clin Invest 48: 2019–2031.PubMedCrossRefGoogle Scholar
  2. 2.
    Levy MN, Zieske H. 1969. Autonomic control of cardiac pacemaker activity and atrioventricular transmission. J Appl Physiol 27: 465–470.PubMedGoogle Scholar
  3. 3.
    Prystowsky EN, Jackman WM, Rinkenberger RL, Heger JJ, Zipes DP. 1981. Effect of autonomic blockade on ventricular refractoriness and atrioventricular nodal conduction in humans. Circ Res 49: 511–518.PubMedGoogle Scholar
  4. 4.
    Higgins CB, Vatner SF, Braunwald E. 1973. Parasympathetic control of the heart. Pharmacol Rev 25: 119–155.PubMedGoogle Scholar
  5. 5.
    Zipes DP, Martins JB, Ruffy R, Prystowsky EN, Elharrar V, Gilmour RF. 1981. Roles of autonomic innervation in the genesis of ventricular arrhythmias. In: FM Abboud, HA Fozzard, JP Gilmore, DJ Reis, eds. Disturbances in Neurogenic Control of the Circulation, pp 225–250. Bethesda, MD: American Physiological Society.Google Scholar
  6. 6.
    Rardon DP, Bailey JC. 1983. Parasympathetic effects on electrophysiological properties of cardiac ventricular tissue. J Amer Coll Cardiol 2:1200–1215.CrossRefGoogle Scholar
  7. 7.
    Levy MN. 1971. Sympathetic-parasympathetic interactions in the heart. Circ Res 29: 437–445.PubMedGoogle Scholar
  8. 8.
    Kent KM, Epstein SE, Cooper T, Jacobowitz DM (1974) Cholinergic innervation of the canine and human ventricular conducting system: Anatomical an electrophysiological consideration. Circulation 50: 948–955.PubMedGoogle Scholar
  9. 9.
    Jacobowitz DM, Cooper T, Barner HB. 1967. Histochemical and chemical studies of the localization of adrenergic and cholinergic nerves in normal and denervated cat hearts. Circ Res 20: 289–298.PubMedGoogle Scholar
  10. 10.
    Roskoski R, Schmid PG, Mayer HE, Abboud FA. 1975. In vitro acetylcholine biosynthesis in normal and failing guinea pig hearts. Circ Res 36: 547–552.PubMedGoogle Scholar
  11. 11.
    Brown OM. 1976. Cat heart acetylcholine: structural proof and distribution. Am J Physiol 231: 781–785.PubMedGoogle Scholar
  12. 12.
    Fields JZ, Roeske WR, Morkin E, Yamamura HI. 1978. Cardiac muscarinic cholinergic receptors. Biochemical identification and characterization. J Biol Chem 253: 3251–3258.PubMedGoogle Scholar
  13. 13.
    Bailey JC, Greenspan K, Elizari MV, Anderson GJ, Fisch C. 1972. Effects of acetylcholine on automaticity and conduction in the proximal portion of the His-Purkinje specialized conduction system of the dog. Circ Res 30: 210–216.PubMedGoogle Scholar
  14. 14.
    Bailey JC, Watanabe AM, Besch HR Jr, Lanthrop DA. 1979. Acetylcholine antagonism of the electrical effects of isoproterenol on canine cardiac Purkinje fibers. Circ Res 44: 378–383.PubMedGoogle Scholar
  15. 15.
    Rardon DP, and Bailey JC. 1983. Direct effects of cholinergic stimulation on ventricular automaticity in guinea pig myocardium. Circ. Res. 52:105–110.PubMedGoogle Scholar
  16. 16.
    Kovacs RJ, and Bailey JC. 1985. Effects of acetylcholine on action potential characteristics of atrial and ventricular myocardium after bilateral cervical vagotomy in the cat. Circ Res 56: 613–620.PubMedGoogle Scholar
  17. 17.
    Waxman MB, and Weld RW. 1977. Termination of ventricular tachycardia by an increase in cardiac vagal drive. Circulation 56: 385–391PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • John C. Bailey
  • Eric N. Prystowsky

There are no affiliations available

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