Invasive electrophysiological tests in the choice of class I antiarrhythmic drugs
Electrophysiological studies have rapidly established their place for the investigation and management of a variety of arrhythmias, particularly for the accurate diagnosis of a wide range of narrow QRS tachycardias. The value of invasive electrophysiology in managing ventricular arrhythmias is largely limited to monomorphic and multimorphic (multiple discrete patterns) ventricular tachycardia. Polymorphic ventricular tachycardia, ventricular flutter and ventricular fibrillation are less amenable to electrophysiological investigation particularly as these arrhythmias may occur as ‘non-specific’ responses to aggressive stimulation protocols. It is unlikely that stable monomorphic ventricular tachycardia is ever a ‘non-specific’ response. The value of electrophysiological investigation of ventricular tachycardia is the facility to induce and terminate the clinically relevant arrhythmia in conditions of relative safety. This permits investigation of the tachycardias haemodynamic consequences, its site of origin and its response to a variety of antiarrhythmic strategies.
KeywordsVentricular Tachycardia Antiarrhythmic Drug Ventricular Tachyarrhythmia Program Stimulation Electrophysiological Investigation
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- 8.Vaughan Williams EM. 1978. Some factors that influence the activity of antiarrhythmic drugs. Br Heart J 40 (suppl): 52–61.Google Scholar