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Concentric left ventricular hypertrophy: a simulation study of mechanics related to transmural oxygen demand and perfusion

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Activation, Metabolism and Perfusion of the Heart

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 70))

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Abstract

A comprehensive model which incorporates the local instantaneous and global time dependent cardiac mechanics, perfusion and energetics is used to study related parameters in concentric left ventricular hypertrophy (LVH) due to pressure overload. The mechanical aspects are analyzed with special attention to the effect of hypertrophy on Emax and on the source resistance of the LV. The local balance between mechanics, oxygen demand and coronary flow are studied and compared to experimental data taken from the published literature. The model presented here represents an attempt to develop a quantitative tool for the study of some phenomena related to LVH.

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Authors
  1. R. Beyar
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  2. S. Sideman
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Editor information

Editors and Affiliations

  1. Rutgers Medical School, Rutgers State University, Piscataway, NJ, 08854, USA

    S. Sideman D.Sc. (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering) (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering)

  2. Department of Biomedical Engineering Technion, Israel Institute of Technology, Haifa, 3200, Israel

    S. Sideman D.Sc. (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering) & R. Beyar M.D., D.Sc. (Senior Lecturer) (Professor of Chemical Engineering and R.J. Matas / Winnipeg Professor of Biomedical Engineering) &  (Senior Lecturer)

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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Beyar, R., Sideman, S. (1987). Concentric left ventricular hypertrophy: a simulation study of mechanics related to transmural oxygen demand and perfusion. In: Sideman, S., Beyar, R. (eds) Activation, Metabolism and Perfusion of the Heart. Developments in Cardiovascular Medicine, vol 70. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3313-2_35

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  • DOI: https://doi.org/10.1007/978-94-009-3313-2_35

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7987-7

  • Online ISBN: 978-94-009-3313-2

  • eBook Packages: Springer Book Archive

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